Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism?
Metal ions, such as selenium, copper, zinc, and iron are naturally present in the environment (air, drinking water, and food) and are vital for cellular functions at chemical, molecular, and biological levels. These trace elements are involved in various biochemical reactions by acting as cofactors...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-04-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00646/full |
| _version_ | 1828886595175972864 |
|---|---|
| author | Marina Serra Marina Serra Amedeo Columbano Ummi Ammarah Ummi Ammarah Massimiliano Mazzone Massimiliano Mazzone Alessio Menga Alessio Menga |
| author_facet | Marina Serra Marina Serra Amedeo Columbano Ummi Ammarah Ummi Ammarah Massimiliano Mazzone Massimiliano Mazzone Alessio Menga Alessio Menga |
| author_sort | Marina Serra |
| collection | DOAJ |
| description | Metal ions, such as selenium, copper, zinc, and iron are naturally present in the environment (air, drinking water, and food) and are vital for cellular functions at chemical, molecular, and biological levels. These trace elements are involved in various biochemical reactions by acting as cofactors for many enzymes and control important biological processes by binding to the receptors and transcription factors. Moreover, they are essential for the stabilization of the cellular structures and for the maintenance of genome stability. A body of preclinical and clinical evidence indicates that dysregulation of metal homeostasis, both at intracellular and tissue level, contributes to the pathogenesis of many different types of cancer. These trace minerals play a crucial role in preventing or accelerating neoplastic cell transformation and in modulating the inflammatory and pro-tumorigenic response in immune cells, such as macrophages, by controlling a plethora of metabolic reactions. In this context, macrophages and cancer cells interact in different manners and some of these interactions are modulated by availability of metals. The current review discusses the new findings and focuses on the involvement of these micronutrients in metabolic and cellular signaling mechanisms that influence macrophage functions, onset of cancer and its progression. An improved understanding of “metallic” cross-talk between macrophages and cancer cells may pave the way for innovative pharmaceutical or dietary interventions in order to restore the balance of these trace elements and also strengthen the chemotherapeutic treatment. |
| first_indexed | 2024-12-13T11:47:19Z |
| format | Article |
| id | doaj.art-747ad4d1609e41b6acf85f8db9e70baa |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T11:47:19Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-747ad4d1609e41b6acf85f8db9e70baa2022-12-21T23:47:28ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-04-011010.3389/fonc.2020.00646520077Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism?Marina Serra0Marina Serra1Amedeo Columbano2Ummi Ammarah3Ummi Ammarah4Massimiliano Mazzone5Massimiliano Mazzone6Alessio Menga7Alessio Menga8Department of Biomedical Sciences, University of Cagliari, Cagliari, ItalyLaboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology (CCB), VIB, Leuven, BelgiumDepartment of Biomedical Sciences, University of Cagliari, Cagliari, ItalyLaboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology (CCB), VIB, Leuven, BelgiumDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center – MBC, University of Torino, Turin, ItalyLaboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology (CCB), VIB, Leuven, BelgiumDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center – MBC, University of Torino, Turin, ItalyLaboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology (CCB), VIB, Leuven, BelgiumDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center – MBC, University of Torino, Turin, ItalyMetal ions, such as selenium, copper, zinc, and iron are naturally present in the environment (air, drinking water, and food) and are vital for cellular functions at chemical, molecular, and biological levels. These trace elements are involved in various biochemical reactions by acting as cofactors for many enzymes and control important biological processes by binding to the receptors and transcription factors. Moreover, they are essential for the stabilization of the cellular structures and for the maintenance of genome stability. A body of preclinical and clinical evidence indicates that dysregulation of metal homeostasis, both at intracellular and tissue level, contributes to the pathogenesis of many different types of cancer. These trace minerals play a crucial role in preventing or accelerating neoplastic cell transformation and in modulating the inflammatory and pro-tumorigenic response in immune cells, such as macrophages, by controlling a plethora of metabolic reactions. In this context, macrophages and cancer cells interact in different manners and some of these interactions are modulated by availability of metals. The current review discusses the new findings and focuses on the involvement of these micronutrients in metabolic and cellular signaling mechanisms that influence macrophage functions, onset of cancer and its progression. An improved understanding of “metallic” cross-talk between macrophages and cancer cells may pave the way for innovative pharmaceutical or dietary interventions in order to restore the balance of these trace elements and also strengthen the chemotherapeutic treatment.https://www.frontiersin.org/article/10.3389/fonc.2020.00646/fullcancerironseleniumcopperzincmetabolism |
| spellingShingle | Marina Serra Marina Serra Amedeo Columbano Ummi Ammarah Ummi Ammarah Massimiliano Mazzone Massimiliano Mazzone Alessio Menga Alessio Menga Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism? Frontiers in Oncology cancer iron selenium copper zinc metabolism |
| title | Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism? |
| title_full | Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism? |
| title_fullStr | Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism? |
| title_full_unstemmed | Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism? |
| title_short | Understanding Metal Dynamics Between Cancer Cells and Macrophages: Competition or Synergism? |
| title_sort | understanding metal dynamics between cancer cells and macrophages competition or synergism |
| topic | cancer iron selenium copper zinc metabolism |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00646/full |
| work_keys_str_mv | AT marinaserra understandingmetaldynamicsbetweencancercellsandmacrophagescompetitionorsynergism AT marinaserra understandingmetaldynamicsbetweencancercellsandmacrophagescompetitionorsynergism AT amedeocolumbano understandingmetaldynamicsbetweencancercellsandmacrophagescompetitionorsynergism AT ummiammarah understandingmetaldynamicsbetweencancercellsandmacrophagescompetitionorsynergism AT ummiammarah understandingmetaldynamicsbetweencancercellsandmacrophagescompetitionorsynergism AT massimilianomazzone understandingmetaldynamicsbetweencancercellsandmacrophagescompetitionorsynergism AT massimilianomazzone understandingmetaldynamicsbetweencancercellsandmacrophagescompetitionorsynergism AT alessiomenga understandingmetaldynamicsbetweencancercellsandmacrophagescompetitionorsynergism AT alessiomenga understandingmetaldynamicsbetweencancercellsandmacrophagescompetitionorsynergism |