Role and regulation of MKP-1 in airway inflammation
Abstract Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over the past decade as playing an instrumental role in the regulation of airway infla...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-08-01
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| Series: | Respiratory Research |
| Online Access: | http://link.springer.com/article/10.1186/s12931-017-0637-3 |
| _version_ | 1818555546088767488 |
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| author | Seyed M. Moosavi Pavan Prabhala Alaina J. Ammit |
| author_facet | Seyed M. Moosavi Pavan Prabhala Alaina J. Ammit |
| author_sort | Seyed M. Moosavi |
| collection | DOAJ |
| description | Abstract Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over the past decade as playing an instrumental role in the regulation of airway inflammation. Not only does MKP-1 serve a critical role as a negative feedback effector, controlling the extent and duration of pro-inflammatory MAPK signalling in airway cells, upregulation of this endogenous phosphatase has also emerged as being one of the key cellular mechanism responsible for the beneficial actions of clinically-used respiratory medicines, including β2-agonists, phosphodiesterase inhibitors and corticosteroids. Herein, we review the role and regulation of MKP-1 in the context of airway inflammation. We initially outline the structure and biochemistry of MKP-1 and summarise the multi-layered molecular mechanisms responsible for MKP-1 production more generally. We then focus in on some of the key in vitro studies in cell types relevant to airway disease that explain how MKP-1 can be regulated in airway inflammation at the transcriptional, post-translation and post-translational level. And finally, we address some of the potential challenges with MKP-1 upregulation that need to be explored further to fully exploit the potential of MKP-1 to repress airway inflammation in chronic respiratory disease. |
| first_indexed | 2024-12-12T09:54:51Z |
| format | Article |
| id | doaj.art-747b035e55cf4b9aa17afa8890e88c66 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-12T09:54:51Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-747b035e55cf4b9aa17afa8890e88c662022-12-22T00:28:10ZengBMCRespiratory Research1465-993X2017-08-0118111210.1186/s12931-017-0637-3Role and regulation of MKP-1 in airway inflammationSeyed M. Moosavi0Pavan Prabhala1Alaina J. Ammit2School of Life Sciences, University of Technology SydneyDepartment of Molecular Pharmacology, University of GroningenSchool of Life Sciences, University of Technology SydneyAbstract Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a protein with anti-inflammatory properties and the archetypal member of the dual-specificity phosphatases (DUSPs) family that have emerged over the past decade as playing an instrumental role in the regulation of airway inflammation. Not only does MKP-1 serve a critical role as a negative feedback effector, controlling the extent and duration of pro-inflammatory MAPK signalling in airway cells, upregulation of this endogenous phosphatase has also emerged as being one of the key cellular mechanism responsible for the beneficial actions of clinically-used respiratory medicines, including β2-agonists, phosphodiesterase inhibitors and corticosteroids. Herein, we review the role and regulation of MKP-1 in the context of airway inflammation. We initially outline the structure and biochemistry of MKP-1 and summarise the multi-layered molecular mechanisms responsible for MKP-1 production more generally. We then focus in on some of the key in vitro studies in cell types relevant to airway disease that explain how MKP-1 can be regulated in airway inflammation at the transcriptional, post-translation and post-translational level. And finally, we address some of the potential challenges with MKP-1 upregulation that need to be explored further to fully exploit the potential of MKP-1 to repress airway inflammation in chronic respiratory disease.http://link.springer.com/article/10.1186/s12931-017-0637-3 |
| spellingShingle | Seyed M. Moosavi Pavan Prabhala Alaina J. Ammit Role and regulation of MKP-1 in airway inflammation Respiratory Research |
| title | Role and regulation of MKP-1 in airway inflammation |
| title_full | Role and regulation of MKP-1 in airway inflammation |
| title_fullStr | Role and regulation of MKP-1 in airway inflammation |
| title_full_unstemmed | Role and regulation of MKP-1 in airway inflammation |
| title_short | Role and regulation of MKP-1 in airway inflammation |
| title_sort | role and regulation of mkp 1 in airway inflammation |
| url | http://link.springer.com/article/10.1186/s12931-017-0637-3 |
| work_keys_str_mv | AT seyedmmoosavi roleandregulationofmkp1inairwayinflammation AT pavanprabhala roleandregulationofmkp1inairwayinflammation AT alainajammit roleandregulationofmkp1inairwayinflammation |