The impact of recipient HLA-Cw and donor killer immunoglobulin-like receptor genotyping on the outcome of patients receiving HLA-matched sibling donor haematopoietic stem cell transplantation for myeloid malignancies

The impact of recipient HLA-Cw and donor killer immunoglobulin-like receptor genotyping on the outcome of patients receiving HLA-matched sibling donor haematopoietic stem cell transplantation for myeloid malignancies

BACKGROUND: The alloreactivity of natural killer cell and certain subsets of T lymphocyte are regulated by the interaction between killer immunoglobulin-like receptors (KIRs) of donor cells and human leukocyte antigen (HLA)-class I molecules on target cells. The interaction has been shown to i...

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Bibliographic Details
Main Authors: Hua Wang, Yi He, Wen-jing Zhai, Mei Wang, Zheng Zhou, Ying-xin Zhao, Si-zhou Feng, Ming-zhe Han
Format: Article
Language:English
Published: SMW supporting association (Trägerverein Swiss Medical Weekly SMW) 2012-12-01
Series:Swiss Medical Weekly
Subjects:
hematopoietic stem cell transplantation
HLA-Cw ligand
killer immunoglobulin-like receptor
myeloid malignancy
outcome.
Online Access:https://www.smw.ch/index.php/smw/article/view/1806

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