Substituent-Dependent Divergent Synthesis of 2-(3-Amino-2,4-dicyanophenyl)pyrroles, Pyrrolyldienols and 3-Amino-1-acylethylidene-2-cyanopyrrolizines via Reaction of Acylethynylpyrroles with Malononitrile

Substituent-Dependent Divergent Synthesis of 2-(3-Amino-2,4-dicyanophenyl)pyrroles, Pyrrolyldienols and 3-Amino-1-acylethylidene-2-cyanopyrrolizines via Reaction of Acylethynylpyrroles with Malononitrile

An efficient method for the synthesis of pharmaceutically and high-tech prospective 2-(3-amino-2,4-dicyanophenyl)pyrroles (in up to 88% yield) via the reaction of easily available substituted acylethynylpyrroles with malononitrile has been developed. The reaction proceeds in the KOH/MeCN system at 0...

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Bibliographic Details
Main Authors: Maxim D. Gotsko, Ivan V. Saliy, Igor A. Ushakov, Lyubov N. Sobenina, Boris A. Trofimov
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
acylethynylpyrroles
malononitrile
2-(3-amino-2,4-dicyanophenyl)pyrroles
pyrrolyldienols
3-amino-1-acylethylidene-2-cyanopyrrolizines
Online Access:https://www.mdpi.com/1420-3049/27/23/8528

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