Metformin alleviates junctional epithelium senescence via the AMPK/SIRT1/autophagy pathway in periodontitis induced by hyperglycemia

Metformin alleviates junctional epithelium senescence via the AMPK/SIRT1/autophagy pathway in periodontitis induced by hyperglycemia

The junctional epithelium (JE) serves a crucial protective role in the periodontium. High glucose-related aging results in accelerated barrier dysfunction of the gingival epithelium, which may be associated with diabetic periodontitis. Metformin, an oral hypoglycemic therapeutic, has been proposed a...

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Bibliographic Details
Main Authors: Xiaoyuan Ye, Yumin Wang, Yanying Tian, Ruonan Bi, Mingyue Li, Chunyan Yang, Li Zhang, Yuguang Gao
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
Periodontitis
Junctional epithelium
Hyperglycemia
Metformin
Senescence
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024035096

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