The Physiological Significance of A-Waves in Early Diabetic Neuropathy: Assessment of Motor Nerve Fibers by Neurophysiological Techniques
Objective: This study aimed to investigate how early A-waves could occur in type II diabetes, and what it implied functionally.Methods: We performed conduction velocity distribution (CVD) test in peroneal nerves of 37 type II diabetic patients with normal nerve conduction study (NCS) and 22 age-matc...
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| Format: | Article |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Systems Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnsys.2021.633915/full |
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| author | Qiong Cai Qiong Cai Guliqiemu Aimair Guliqiemu Aimair Wen-Xiao Xu Wen-Xiao Xu Pei-Yao Xiao Pei-Yao Xiao Lie-Hua Liu Yin-Xing Liang Yin-Xing Liang Chao Wu Chao Wu Song-Jie Liao Song-Jie Liao |
| author_facet | Qiong Cai Qiong Cai Guliqiemu Aimair Guliqiemu Aimair Wen-Xiao Xu Wen-Xiao Xu Pei-Yao Xiao Pei-Yao Xiao Lie-Hua Liu Yin-Xing Liang Yin-Xing Liang Chao Wu Chao Wu Song-Jie Liao Song-Jie Liao |
| author_sort | Qiong Cai |
| collection | DOAJ |
| description | Objective: This study aimed to investigate how early A-waves could occur in type II diabetes, and what it implied functionally.Methods: We performed conduction velocity distribution (CVD) test in peroneal nerves of 37 type II diabetic patients with normal nerve conduction study (NCS) and 22 age-matched controls. The electrophysiological data and clinical information were analyzed.Results: A-waves were observed in 45.9% of diabetic patients and only in 1 person in healthy controls, all detected in the tibial nerves. The diabetic patients with A-waves showed faster conduction velocity in all quartiles in the motor peroneal nerves compared to the patients without A-waves, and their CVD histograms were shifted to the right side, consisting of a significantly larger percentage of fast conducting fibers. There was no significant difference in the CVD values of the upper extremity nerves among the patients with and without A-waves and the healthy controls.Conclusion: A-waves could occur in type II diabetes as early as when NCS showed normal, and represented as a sign of neuropathy as well as a sign of rescued motor nerve function. |
| first_indexed | 2024-12-18T00:03:57Z |
| format | Article |
| id | doaj.art-7487865203914819b1fa4a7815527ca8 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-18T00:03:57Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-7487865203914819b1fa4a7815527ca82022-12-21T21:27:53ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372021-01-011510.3389/fnsys.2021.633915633915The Physiological Significance of A-Waves in Early Diabetic Neuropathy: Assessment of Motor Nerve Fibers by Neurophysiological TechniquesQiong Cai0Qiong Cai1Guliqiemu Aimair2Guliqiemu Aimair3Wen-Xiao Xu4Wen-Xiao Xu5Pei-Yao Xiao6Pei-Yao Xiao7Lie-Hua Liu8Yin-Xing Liang9Yin-Xing Liang10Chao Wu11Chao Wu12Song-Jie Liao13Song-Jie Liao14Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaDepartment of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaGuangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou, ChinaObjective: This study aimed to investigate how early A-waves could occur in type II diabetes, and what it implied functionally.Methods: We performed conduction velocity distribution (CVD) test in peroneal nerves of 37 type II diabetic patients with normal nerve conduction study (NCS) and 22 age-matched controls. The electrophysiological data and clinical information were analyzed.Results: A-waves were observed in 45.9% of diabetic patients and only in 1 person in healthy controls, all detected in the tibial nerves. The diabetic patients with A-waves showed faster conduction velocity in all quartiles in the motor peroneal nerves compared to the patients without A-waves, and their CVD histograms were shifted to the right side, consisting of a significantly larger percentage of fast conducting fibers. There was no significant difference in the CVD values of the upper extremity nerves among the patients with and without A-waves and the healthy controls.Conclusion: A-waves could occur in type II diabetes as early as when NCS showed normal, and represented as a sign of neuropathy as well as a sign of rescued motor nerve function.https://www.frontiersin.org/articles/10.3389/fnsys.2021.633915/fulltype II diabetesdiabetic neuropathyA-wavesconduction velocity distributionnerve conduction studies |
| spellingShingle | Qiong Cai Qiong Cai Guliqiemu Aimair Guliqiemu Aimair Wen-Xiao Xu Wen-Xiao Xu Pei-Yao Xiao Pei-Yao Xiao Lie-Hua Liu Yin-Xing Liang Yin-Xing Liang Chao Wu Chao Wu Song-Jie Liao Song-Jie Liao The Physiological Significance of A-Waves in Early Diabetic Neuropathy: Assessment of Motor Nerve Fibers by Neurophysiological Techniques Frontiers in Systems Neuroscience type II diabetes diabetic neuropathy A-waves conduction velocity distribution nerve conduction studies |
| title | The Physiological Significance of A-Waves in Early Diabetic Neuropathy: Assessment of Motor Nerve Fibers by Neurophysiological Techniques |
| title_full | The Physiological Significance of A-Waves in Early Diabetic Neuropathy: Assessment of Motor Nerve Fibers by Neurophysiological Techniques |
| title_fullStr | The Physiological Significance of A-Waves in Early Diabetic Neuropathy: Assessment of Motor Nerve Fibers by Neurophysiological Techniques |
| title_full_unstemmed | The Physiological Significance of A-Waves in Early Diabetic Neuropathy: Assessment of Motor Nerve Fibers by Neurophysiological Techniques |
| title_short | The Physiological Significance of A-Waves in Early Diabetic Neuropathy: Assessment of Motor Nerve Fibers by Neurophysiological Techniques |
| title_sort | physiological significance of a waves in early diabetic neuropathy assessment of motor nerve fibers by neurophysiological techniques |
| topic | type II diabetes diabetic neuropathy A-waves conduction velocity distribution nerve conduction studies |
| url | https://www.frontiersin.org/articles/10.3389/fnsys.2021.633915/full |
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