Curcumin–Copper Complex Nanoparticles for the Management of Triple-Negative Breast Cancer
Breast cancer is the most common cancer diagnosed among females worldwide. Although breast cancer survival has largely improved in the past 30 years, it remains highly heterogeneous in its response to treatment. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expres...
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| Format: | Article |
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MDPI AG
2018-11-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/8/11/884 |
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| author | Khaled Greish Valeria Pittalà Sebastien Taurin Safa Taha Fatemah Bahman Aanchal Mathur Anfal Jasim Fatima Mohammed Ibrahim M. El-Deeb Salim Fredericks Fiza Rashid-Doubell |
| author_facet | Khaled Greish Valeria Pittalà Sebastien Taurin Safa Taha Fatemah Bahman Aanchal Mathur Anfal Jasim Fatima Mohammed Ibrahim M. El-Deeb Salim Fredericks Fiza Rashid-Doubell |
| author_sort | Khaled Greish |
| collection | DOAJ |
| description | Breast cancer is the most common cancer diagnosed among females worldwide. Although breast cancer survival has largely improved in the past 30 years, it remains highly heterogeneous in its response to treatment. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression of the estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor-2 (Her2). While TNBC may initially be responsive to chemotherapy, recurrence and subsequent high mortality rates are frequently reported. Studies have shown curcumin and its derivatives to be effective against TNBC cell lines in vitro. To improve its anti-cancer effects, we have synthesized Fe<sup>3+</sup>⁻curcumin (Fe⁻Cur<sub>3</sub>) and Cu<sup>2+</sup>⁻curcumin (CD) complexes and investigated them experimentally. Further, CD was encapsulated into a poly(styrene)-co-maleic acid (SMA) micelle to enhance its stability. We assessed the cytotoxicity of these formulations both in vitro and in vivo. SMA⁻CD demonstrated dose-dependent cytotoxicity and abolished TNBC tumor growth in vivo. The encapsulation of the curcumin⁻copper complex improved its anti-cancer activity without overt adverse effects in a murine model of TNBC. These results provide evidence and insights into the value of nanoformulations in enhancing drug-delivery and increasing the potential therapeutic efficacy of curcumin derivatives. |
| first_indexed | 2024-12-10T23:07:52Z |
| format | Article |
| id | doaj.art-748815512985440cae85ae55d8870acc |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-10T23:07:52Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-748815512985440cae85ae55d8870acc2022-12-22T01:30:01ZengMDPI AGNanomaterials2079-49912018-11-0181188410.3390/nano8110884nano8110884Curcumin–Copper Complex Nanoparticles for the Management of Triple-Negative Breast CancerKhaled Greish0Valeria Pittalà1Sebastien Taurin2Safa Taha3Fatemah Bahman4Aanchal Mathur5Anfal Jasim6Fatima Mohammed7Ibrahim M. El-Deeb8Salim Fredericks9Fiza Rashid-Doubell10Department of Molecular Medicine, College of Medicine and Medical Sciences, and Nanomedicine Research Unite, Princess Al-Jawhara Centre for Molecular Medicine and Inherited Disorder, Arabian Gulf University, Manama 328, BahrainDepartment of Drug Sciences, University of Catania, Catania I-95125, ItalyDepartment of Molecular Medicine, College of Medicine and Medical Sciences, and Nanomedicine Research Unite, Princess Al-Jawhara Centre for Molecular Medicine and Inherited Disorder, Arabian Gulf University, Manama 328, BahrainDepartment of Molecular Medicine, College of Medicine and Medical Sciences, and Nanomedicine Research Unite, Princess Al-Jawhara Centre for Molecular Medicine and Inherited Disorder, Arabian Gulf University, Manama 328, BahrainDepartment of Molecular Medicine, College of Medicine and Medical Sciences, and Nanomedicine Research Unite, Princess Al-Jawhara Centre for Molecular Medicine and Inherited Disorder, Arabian Gulf University, Manama 328, BahrainDepartment of Molecular Medicine, College of Medicine and Medical Sciences, and Nanomedicine Research Unite, Princess Al-Jawhara Centre for Molecular Medicine and Inherited Disorder, Arabian Gulf University, Manama 328, BahrainDepartment of Molecular Medicine, College of Medicine and Medical Sciences, and Nanomedicine Research Unite, Princess Al-Jawhara Centre for Molecular Medicine and Inherited Disorder, Arabian Gulf University, Manama 328, BahrainDepartment of Basic Medical Sciences, Royal College of Surgeons in Ireland (RCSI), Medical University of Bahrain, Busaiteen 221, BahrainDepartment of Basic Medical Sciences, Royal College of Surgeons in Ireland (RCSI), Medical University of Bahrain, Busaiteen 221, BahrainDepartment of Basic Medical Sciences, Royal College of Surgeons in Ireland (RCSI), Medical University of Bahrain, Busaiteen 221, BahrainDepartment of Basic Medical Sciences, Royal College of Surgeons in Ireland (RCSI), Medical University of Bahrain, Busaiteen 221, BahrainBreast cancer is the most common cancer diagnosed among females worldwide. Although breast cancer survival has largely improved in the past 30 years, it remains highly heterogeneous in its response to treatment. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression of the estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor-2 (Her2). While TNBC may initially be responsive to chemotherapy, recurrence and subsequent high mortality rates are frequently reported. Studies have shown curcumin and its derivatives to be effective against TNBC cell lines in vitro. To improve its anti-cancer effects, we have synthesized Fe<sup>3+</sup>⁻curcumin (Fe⁻Cur<sub>3</sub>) and Cu<sup>2+</sup>⁻curcumin (CD) complexes and investigated them experimentally. Further, CD was encapsulated into a poly(styrene)-co-maleic acid (SMA) micelle to enhance its stability. We assessed the cytotoxicity of these formulations both in vitro and in vivo. SMA⁻CD demonstrated dose-dependent cytotoxicity and abolished TNBC tumor growth in vivo. The encapsulation of the curcumin⁻copper complex improved its anti-cancer activity without overt adverse effects in a murine model of TNBC. These results provide evidence and insights into the value of nanoformulations in enhancing drug-delivery and increasing the potential therapeutic efficacy of curcumin derivatives.https://www.mdpi.com/2079-4991/8/11/884Curcumincurcumin complexcoppernanoparticlesbreast cancerUV stabilityrelease studyCDTNBC |
| spellingShingle | Khaled Greish Valeria Pittalà Sebastien Taurin Safa Taha Fatemah Bahman Aanchal Mathur Anfal Jasim Fatima Mohammed Ibrahim M. El-Deeb Salim Fredericks Fiza Rashid-Doubell Curcumin–Copper Complex Nanoparticles for the Management of Triple-Negative Breast Cancer Nanomaterials Curcumin curcumin complex copper nanoparticles breast cancer UV stability release study CD TNBC |
| title | Curcumin–Copper Complex Nanoparticles for the Management of Triple-Negative Breast Cancer |
| title_full | Curcumin–Copper Complex Nanoparticles for the Management of Triple-Negative Breast Cancer |
| title_fullStr | Curcumin–Copper Complex Nanoparticles for the Management of Triple-Negative Breast Cancer |
| title_full_unstemmed | Curcumin–Copper Complex Nanoparticles for the Management of Triple-Negative Breast Cancer |
| title_short | Curcumin–Copper Complex Nanoparticles for the Management of Triple-Negative Breast Cancer |
| title_sort | curcumin copper complex nanoparticles for the management of triple negative breast cancer |
| topic | Curcumin curcumin complex copper nanoparticles breast cancer UV stability release study CD TNBC |
| url | https://www.mdpi.com/2079-4991/8/11/884 |
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