Amyloid Precursor Protein (APP) and GABAergic Neurotransmission

Amyloid Precursor Protein (APP) and GABAergic Neurotransmission

The amyloid precursor protein (APP) is the parent polypeptide from which amyloid-beta (Aβ) peptides, key etiological agents of Alzheimer’s disease (AD), are generated by sequential proteolytic processing involving β- and γ-secretases. APP mutations underlie famil...

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Bibliographic Details
Main Author:	Bor Luen Tang
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	Cells
Subjects:	amyloid precursor protein (APP) amyloid-beta (Aβ) gamma-aminobutyric acid (GABA) GABA receptor potassium chloride cotransporter 2 (KCC2)
Online Access:	https://www.mdpi.com/2073-4409/8/6/550

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