Spatiotemporal changes in microtubule dynamics during dendritic morphogenesis
Dendritic morphogenesis requires dynamic microtubules (MTs) to form a coordinated cytoskeletal network during development. Dynamic MTs are characterized by their number, polarity and speed of polymerization. Previous studies described a correlation between anterograde MT growth and terminal branch e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Fly |
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| Online Access: | http://dx.doi.org/10.1080/19336934.2021.1976033 |
| _version_ | 1797678364001042432 |
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| author | Chun Hu Pan Feng Meilan Chen Yan Tang Peter Soba |
| author_facet | Chun Hu Pan Feng Meilan Chen Yan Tang Peter Soba |
| author_sort | Chun Hu |
| collection | DOAJ |
| description | Dendritic morphogenesis requires dynamic microtubules (MTs) to form a coordinated cytoskeletal network during development. Dynamic MTs are characterized by their number, polarity and speed of polymerization. Previous studies described a correlation between anterograde MT growth and terminal branch extension in Drosophila dendritic arborization (da) neurons, suggesting a model that anterograde MT polymerization provides a driving force for dendritic branching. We recently found that the Ste20-like kinase Tao specifically regulates dendritic branching by controlling the number of dynamic MTs in a kinase activity-dependent fashion, without affecting MT polarity or speed. This finding raises the interesting question of how MT dynamics affects dendritic morphogenesis, and if Tao kinase activity is developmentally regulated to coordinate MT dynamics and dendritic morphogenesis. We explored the possible correlation between MT dynamics and dendritic morphogenesis together with the activity changes of Tao kinase in C1da and C4da neurons during larval development. Our data show that spatiotemporal changes in the number of dynamic MTs, but not polarity or polymerization speed, correlate with dendritic branching and Tao kinase activity. Our findings suggest that Tao kinase limits dendritic branching by controlling the abundance of dynamic MTs and we propose a novel model on how regulation of MT dynamics might influence dendritic morphogenesis. |
| first_indexed | 2024-03-11T22:58:39Z |
| format | Article |
| id | doaj.art-748b0a30e668453b8011a17d43fc0e3e |
| institution | Directory Open Access Journal |
| issn | 1933-6934 1933-6942 |
| language | English |
| last_indexed | 2024-03-11T22:58:39Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Fly |
| spelling | doaj.art-748b0a30e668453b8011a17d43fc0e3e2023-09-21T15:17:01ZengTaylor & Francis GroupFly1933-69341933-69422022-12-01161132310.1080/19336934.2021.19760331976033Spatiotemporal changes in microtubule dynamics during dendritic morphogenesisChun Hu0Pan Feng1Meilan Chen2Yan Tang3Peter Soba4Institute for Brain Research and Rehabilitation, South China Normal UniversityInstitute for Brain Research and Rehabilitation, South China Normal UniversityThe Second People’s Hospital of Guangdong ProvinceLimes Institute, University of BonnLimes Institute, University of BonnDendritic morphogenesis requires dynamic microtubules (MTs) to form a coordinated cytoskeletal network during development. Dynamic MTs are characterized by their number, polarity and speed of polymerization. Previous studies described a correlation between anterograde MT growth and terminal branch extension in Drosophila dendritic arborization (da) neurons, suggesting a model that anterograde MT polymerization provides a driving force for dendritic branching. We recently found that the Ste20-like kinase Tao specifically regulates dendritic branching by controlling the number of dynamic MTs in a kinase activity-dependent fashion, without affecting MT polarity or speed. This finding raises the interesting question of how MT dynamics affects dendritic morphogenesis, and if Tao kinase activity is developmentally regulated to coordinate MT dynamics and dendritic morphogenesis. We explored the possible correlation between MT dynamics and dendritic morphogenesis together with the activity changes of Tao kinase in C1da and C4da neurons during larval development. Our data show that spatiotemporal changes in the number of dynamic MTs, but not polarity or polymerization speed, correlate with dendritic branching and Tao kinase activity. Our findings suggest that Tao kinase limits dendritic branching by controlling the abundance of dynamic MTs and we propose a novel model on how regulation of MT dynamics might influence dendritic morphogenesis.http://dx.doi.org/10.1080/19336934.2021.1976033microtubulepolymerizationdendritic morphogenesisdrosophilaneuronal developmenttao kinasespatiotemporal changes |
| spellingShingle | Chun Hu Pan Feng Meilan Chen Yan Tang Peter Soba Spatiotemporal changes in microtubule dynamics during dendritic morphogenesis Fly microtubule polymerization dendritic morphogenesis drosophila neuronal development tao kinase spatiotemporal changes |
| title | Spatiotemporal changes in microtubule dynamics during dendritic morphogenesis |
| title_full | Spatiotemporal changes in microtubule dynamics during dendritic morphogenesis |
| title_fullStr | Spatiotemporal changes in microtubule dynamics during dendritic morphogenesis |
| title_full_unstemmed | Spatiotemporal changes in microtubule dynamics during dendritic morphogenesis |
| title_short | Spatiotemporal changes in microtubule dynamics during dendritic morphogenesis |
| title_sort | spatiotemporal changes in microtubule dynamics during dendritic morphogenesis |
| topic | microtubule polymerization dendritic morphogenesis drosophila neuronal development tao kinase spatiotemporal changes |
| url | http://dx.doi.org/10.1080/19336934.2021.1976033 |
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