Impact of The Endometrioma on Ovarian Response and Pregnancy Rate in In Vitro Fertilization Cycles
Background: Our objective was to evaluate the effect of ovarian endometrioma on ovarian stimulation outcomes in in vitro fertilization cycles (IVF). Materials and Methods: In this prospective cohort study, we followed 103 patients who underwent intra-cytoplasmic sperm injection (ICSI) procedure...
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2014-04-01
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| Series: | International Journal of Fertility and Sterility |
| Subjects: | |
| Online Access: | http://www.ijfs.ir/article_45218_2187f96b8e5380ab665dc6dcedb8af6b.pdf |
| _version_ | 1818192244679639040 |
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| author | Mahnaz Ashrafi Taravat Fakheri Kiandokht Kiani Maria Sadeghi Mohammad Reza Akhoond |
| author_facet | Mahnaz Ashrafi Taravat Fakheri Kiandokht Kiani Maria Sadeghi Mohammad Reza Akhoond |
| author_sort | Mahnaz Ashrafi |
| collection | DOAJ |
| description | Background: Our objective was to evaluate the effect of ovarian endometrioma on ovarian stimulation outcomes in in vitro fertilization cycles (IVF). Materials and Methods: In this prospective cohort study, we followed 103 patients who underwent intra-cytoplasmic sperm injection (ICSI) procedures over a 24-months period. The study group consisted of 47 infertile women with either unilateral or bilateral ovarian endometrial cysts of less than 3 cm. The control group consisting of 57 patients with mild male factor infertility was candidate for ICSI treatment during the same time period as the study groups. Both groups were compared for number of oocytes retrieved, grades of oocytes, as well as embryo quantity and quality. Results: Our results showed similar follicle numbers, good embryo grades (A or B) and pregnancy rates in the compared groups. However, patients with endometrioma had higher gonadotropin consumption than the control group. The mean number of retrieved oocytes in patients with endometrioma was significantly lower than control group (6.6 ± 3.74 vs. 10.4 ± 5.25) (p < 0.001). In addition, patients with endometrioma had significantly lower numbers of metaphase II (MII) oocytes (5 ± 3.21) than controls (8.2 ± 5.4) (p < 0.001). In patients with unilateral endometrioma, there were no significant differences in main outcome measures between normal and involved ovaries in the patients with endometrioma. Conclusion: Patients with ovarian endometrioma had poor outcome. They showed poor ovarian response with lower total numbers of retrieved oocytes and lower MII oocytes during the stimulation phase; however, it does not affect the total number of embryos transferred per patient, quality of embryos, and pregnancy rate per patient. |
| first_indexed | 2024-12-12T00:27:26Z |
| format | Article |
| id | doaj.art-748b9ee4c22f4882a6449eeca33c79d0 |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-12-12T00:27:26Z |
| publishDate | 2014-04-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-748b9ee4c22f4882a6449eeca33c79d02022-12-22T00:44:35ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782014-04-0181293445218Impact of The Endometrioma on Ovarian Response and Pregnancy Rate in In Vitro Fertilization CyclesMahnaz Ashrafi0Taravat Fakheri1Kiandokht Kiani2Maria Sadeghi3Mohammad Reza Akhoond4Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran;Department of Obstetrics and Gynecology, Iran UniveDepartment of Obstetrics and Gynecology, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran;4Vali-e-Asr Reproductive Health Research Center, TeDepartment of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran5Statistics Department, Mathematical Science and Computer Faculty, Shahid Chamran University, Ahwaz, IranBackground: Our objective was to evaluate the effect of ovarian endometrioma on ovarian stimulation outcomes in in vitro fertilization cycles (IVF). Materials and Methods: In this prospective cohort study, we followed 103 patients who underwent intra-cytoplasmic sperm injection (ICSI) procedures over a 24-months period. The study group consisted of 47 infertile women with either unilateral or bilateral ovarian endometrial cysts of less than 3 cm. The control group consisting of 57 patients with mild male factor infertility was candidate for ICSI treatment during the same time period as the study groups. Both groups were compared for number of oocytes retrieved, grades of oocytes, as well as embryo quantity and quality. Results: Our results showed similar follicle numbers, good embryo grades (A or B) and pregnancy rates in the compared groups. However, patients with endometrioma had higher gonadotropin consumption than the control group. The mean number of retrieved oocytes in patients with endometrioma was significantly lower than control group (6.6 ± 3.74 vs. 10.4 ± 5.25) (p < 0.001). In addition, patients with endometrioma had significantly lower numbers of metaphase II (MII) oocytes (5 ± 3.21) than controls (8.2 ± 5.4) (p < 0.001). In patients with unilateral endometrioma, there were no significant differences in main outcome measures between normal and involved ovaries in the patients with endometrioma. Conclusion: Patients with ovarian endometrioma had poor outcome. They showed poor ovarian response with lower total numbers of retrieved oocytes and lower MII oocytes during the stimulation phase; however, it does not affect the total number of embryos transferred per patient, quality of embryos, and pregnancy rate per patient.http://www.ijfs.ir/article_45218_2187f96b8e5380ab665dc6dcedb8af6b.pdfendometriomaovulation inductionin vitro fertilizationpregnancy rate |
| spellingShingle | Mahnaz Ashrafi Taravat Fakheri Kiandokht Kiani Maria Sadeghi Mohammad Reza Akhoond Impact of The Endometrioma on Ovarian Response and Pregnancy Rate in In Vitro Fertilization Cycles International Journal of Fertility and Sterility endometrioma ovulation induction in vitro fertilization pregnancy rate |
| title | Impact of The Endometrioma on Ovarian Response and Pregnancy Rate in In Vitro Fertilization Cycles |
| title_full | Impact of The Endometrioma on Ovarian Response and Pregnancy Rate in In Vitro Fertilization Cycles |
| title_fullStr | Impact of The Endometrioma on Ovarian Response and Pregnancy Rate in In Vitro Fertilization Cycles |
| title_full_unstemmed | Impact of The Endometrioma on Ovarian Response and Pregnancy Rate in In Vitro Fertilization Cycles |
| title_short | Impact of The Endometrioma on Ovarian Response and Pregnancy Rate in In Vitro Fertilization Cycles |
| title_sort | impact of the endometrioma on ovarian response and pregnancy rate in in vitro fertilization cycles |
| topic | endometrioma ovulation induction in vitro fertilization pregnancy rate |
| url | http://www.ijfs.ir/article_45218_2187f96b8e5380ab665dc6dcedb8af6b.pdf |
| work_keys_str_mv | AT mahnazashrafi impactoftheendometriomaonovarianresponseandpregnancyrateininvitrofertilizationcycles AT taravatfakheri impactoftheendometriomaonovarianresponseandpregnancyrateininvitrofertilizationcycles AT kiandokhtkiani impactoftheendometriomaonovarianresponseandpregnancyrateininvitrofertilizationcycles AT mariasadeghi impactoftheendometriomaonovarianresponseandpregnancyrateininvitrofertilizationcycles AT mohammadrezaakhoond impactoftheendometriomaonovarianresponseandpregnancyrateininvitrofertilizationcycles |