Diagnostic value of maternal alpha-fetoprotein variants in second-trimester biochemical screening for trisomy 21 and 18

Diagnostic value of maternal alpha-fetoprotein variants in second-trimester biochemical screening for trisomy 21 and 18

Abstract To evaluate the clinical predictive value of serum alpha-fetoprotein variants (AFP-L2, AFP-L3) in combination with maternal serum prenatal screening biomarkers in predicting fetal trisomy 21 and trisomy 18. We analyze the data of singleton pregnant women at 15–20+6 weeks of 731,922 gravidas...

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Bibliographic Details
Main Authors:	Yiming Chen, Yijie Chen, Wenwen Ning, Wen Zhang, Liyao Li, Xiaoying Wang, Yixuan Yin, Huimin Zhang
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-08-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-022-16807-x

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