Coronary microvascular dysfunction as a chronic inflammatory state: Is there a role for omega-3 fatty acid treatment?
Coronary microvascular dysfunction is a ubiquitous pathologic process that is operational in ischemia with no obstructive coronary artery disease and other cardiovascular disorders including heart failure with preserved ejection fraction. It may, in fact, be a manifestation of a multi-systemic condi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
|
| Series: | American Heart Journal Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602222000155 |
| _version_ | 1818272813785546752 |
|---|---|
| author | Ellen C. Keeley Eileen M. Handberg Janet Wei C. Noel Bairey Merz Carl J. Pepine |
| author_facet | Ellen C. Keeley Eileen M. Handberg Janet Wei C. Noel Bairey Merz Carl J. Pepine |
| author_sort | Ellen C. Keeley |
| collection | DOAJ |
| description | Coronary microvascular dysfunction is a ubiquitous pathologic process that is operational in ischemia with no obstructive coronary artery disease and other cardiovascular disorders including heart failure with preserved ejection fraction. It may, in fact, be a manifestation of a multi-systemic condition of small vessel dysfunction that also affects the brain and kidneys. While the pathophysiology driving coronary microvascular dysfunction is multifactorial, chronic inflammation plays an important role. Resolution of inflammation is an active process mediated, in part, by a family of locally active mediators biosynthesized from omega-3 fatty acids, collectively referred to as specialized pro-resolving mediators. Omega-3 fatty acid treatment modulates inflammation and is associated with improved cardiovascular outcomes and attenuation of plaque progression on cardiovascular imaging. Whether omega-3 fatty acid treatment attenuates coronary microvascular dysfunction is unknown. |
| first_indexed | 2024-12-12T21:48:02Z |
| format | Article |
| id | doaj.art-748e0384e48c4cf688521a5d5dbf08b1 |
| institution | Directory Open Access Journal |
| issn | 2666-6022 |
| language | English |
| last_indexed | 2024-12-12T21:48:02Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj.art-748e0384e48c4cf688521a5d5dbf08b12022-12-22T00:10:52ZengElsevierAmerican Heart Journal Plus2666-60222022-01-0113100098Coronary microvascular dysfunction as a chronic inflammatory state: Is there a role for omega-3 fatty acid treatment?Ellen C. Keeley0Eileen M. Handberg1Janet Wei2C. Noel Bairey Merz3Carl J. Pepine4Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, FL, United States of America; Corresponding author at: Division of Cardiovascular Medicine, University of Florida, 1600 SW Archer Road, P.O. Box 100277, Gainesville, FL 32610-0277, United States of America.Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, FL, United States of AmericaBarbra Streisand Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States of AmericaBarbra Streisand Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States of AmericaDivision of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, FL, United States of AmericaCoronary microvascular dysfunction is a ubiquitous pathologic process that is operational in ischemia with no obstructive coronary artery disease and other cardiovascular disorders including heart failure with preserved ejection fraction. It may, in fact, be a manifestation of a multi-systemic condition of small vessel dysfunction that also affects the brain and kidneys. While the pathophysiology driving coronary microvascular dysfunction is multifactorial, chronic inflammation plays an important role. Resolution of inflammation is an active process mediated, in part, by a family of locally active mediators biosynthesized from omega-3 fatty acids, collectively referred to as specialized pro-resolving mediators. Omega-3 fatty acid treatment modulates inflammation and is associated with improved cardiovascular outcomes and attenuation of plaque progression on cardiovascular imaging. Whether omega-3 fatty acid treatment attenuates coronary microvascular dysfunction is unknown.http://www.sciencedirect.com/science/article/pii/S2666602222000155Coronary microvascular dysfunctionINOCASpecialized pro-resolving mediatorsOmega-3 fatty acid |
| spellingShingle | Ellen C. Keeley Eileen M. Handberg Janet Wei C. Noel Bairey Merz Carl J. Pepine Coronary microvascular dysfunction as a chronic inflammatory state: Is there a role for omega-3 fatty acid treatment? American Heart Journal Plus Coronary microvascular dysfunction INOCA Specialized pro-resolving mediators Omega-3 fatty acid |
| title | Coronary microvascular dysfunction as a chronic inflammatory state: Is there a role for omega-3 fatty acid treatment? |
| title_full | Coronary microvascular dysfunction as a chronic inflammatory state: Is there a role for omega-3 fatty acid treatment? |
| title_fullStr | Coronary microvascular dysfunction as a chronic inflammatory state: Is there a role for omega-3 fatty acid treatment? |
| title_full_unstemmed | Coronary microvascular dysfunction as a chronic inflammatory state: Is there a role for omega-3 fatty acid treatment? |
| title_short | Coronary microvascular dysfunction as a chronic inflammatory state: Is there a role for omega-3 fatty acid treatment? |
| title_sort | coronary microvascular dysfunction as a chronic inflammatory state is there a role for omega 3 fatty acid treatment |
| topic | Coronary microvascular dysfunction INOCA Specialized pro-resolving mediators Omega-3 fatty acid |
| url | http://www.sciencedirect.com/science/article/pii/S2666602222000155 |
| work_keys_str_mv | AT ellenckeeley coronarymicrovasculardysfunctionasachronicinflammatorystateistherearoleforomega3fattyacidtreatment AT eileenmhandberg coronarymicrovasculardysfunctionasachronicinflammatorystateistherearoleforomega3fattyacidtreatment AT janetwei coronarymicrovasculardysfunctionasachronicinflammatorystateistherearoleforomega3fattyacidtreatment AT cnoelbaireymerz coronarymicrovasculardysfunctionasachronicinflammatorystateistherearoleforomega3fattyacidtreatment AT carljpepine coronarymicrovasculardysfunctionasachronicinflammatorystateistherearoleforomega3fattyacidtreatment |