Computational modelling supports that dengue virus envelope antibodies can bind to SARS-CoV-2 receptor binding sites: Is pre-exposure to dengue virus protective against COVID-19 severity?
The world is going through the scourge of the COVID-19 pandemic since January 2020. However, the pandemic appears to be less severe in highly dengue endemic countries. In this connection, several studies reported that sero-diagnostic tests for dengue virus (DV) yielded considerable false-positive re...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Computational and Structural Biotechnology Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037020305626 |
| _version_ | 1819320401916854272 |
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| author | Himadri Nath Abinash Mallick Subrata Roy Soumi Sukla Subhajit Biswas |
| author_facet | Himadri Nath Abinash Mallick Subrata Roy Soumi Sukla Subhajit Biswas |
| author_sort | Himadri Nath |
| collection | DOAJ |
| description | The world is going through the scourge of the COVID-19 pandemic since January 2020. However, the pandemic appears to be less severe in highly dengue endemic countries. In this connection, several studies reported that sero-diagnostic tests for dengue virus (DV) yielded considerable false-positive results for SARS-CoV-2 and vice versa in dengue endemic regions, thereby indicating towards potential cross-reactivity between these two viruses. We anticipated that SARS-CoV-2 and DV might share antigenic similarity and performed computational docking studies to test this hypothesis. Our results predicted with high confidence that human DV antibodies can indeed, bind to RBD of SARS-CoV-2 Spike protein. Some of these interactions can also potentially intercept human ACE2 receptor binding to RBM. Dengue serum samples predating the COVID-19, had been found to cross-react with SARS-CoV-2 Spike and this provides direct experimental validation of our predictions. Our analysis also showed that m396 and 80R antibodies (against SARS-CoV-1) did not dock with RBM of SARS-CoV-2, a fact already proven experimentally. This confirmed reliability and robustness of our approach. So, it is highly probable that immunological memory/antibodies to DV in endemic countries may reduce the severity and spread of COVID-19. It is not known whether SARS-CoV-2 antibodies will hinder DV infections by binding to DV particles and reduce dengue incidences in the future or, augment DV infection and severity by deploying antibody-dependent enhancement. |
| first_indexed | 2024-12-24T11:19:00Z |
| format | Article |
| id | doaj.art-748e0d86d94d41dab8028d83cdb81093 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-24T11:19:00Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-748e0d86d94d41dab8028d83cdb810932022-12-21T16:58:18ZengElsevierComputational and Structural Biotechnology Journal2001-03702021-01-0119459466Computational modelling supports that dengue virus envelope antibodies can bind to SARS-CoV-2 receptor binding sites: Is pre-exposure to dengue virus protective against COVID-19 severity?Himadri Nath0Abinash Mallick1Subrata Roy2Soumi Sukla3Subhajit Biswas4Infectious Diseases & Immunology Division, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), 4, Raja S.C. Mullick Rd, Jadavpur, Kolkata 700032, West Bengal, IndiaInfectious Diseases & Immunology Division, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), 4, Raja S.C. Mullick Rd, Jadavpur, Kolkata 700032, West Bengal, IndiaInfectious Diseases & Immunology Division, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), 4, Raja S.C. Mullick Rd, Jadavpur, Kolkata 700032, West Bengal, IndiaNational Institute of Pharmaceutical Education and Research, 168, Maniktala Main Road, Kolkata 700054, West Bengal, IndiaInfectious Diseases & Immunology Division, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), 4, Raja S.C. Mullick Rd, Jadavpur, Kolkata 700032, West Bengal, India; Corresponding author.The world is going through the scourge of the COVID-19 pandemic since January 2020. However, the pandemic appears to be less severe in highly dengue endemic countries. In this connection, several studies reported that sero-diagnostic tests for dengue virus (DV) yielded considerable false-positive results for SARS-CoV-2 and vice versa in dengue endemic regions, thereby indicating towards potential cross-reactivity between these two viruses. We anticipated that SARS-CoV-2 and DV might share antigenic similarity and performed computational docking studies to test this hypothesis. Our results predicted with high confidence that human DV antibodies can indeed, bind to RBD of SARS-CoV-2 Spike protein. Some of these interactions can also potentially intercept human ACE2 receptor binding to RBM. Dengue serum samples predating the COVID-19, had been found to cross-react with SARS-CoV-2 Spike and this provides direct experimental validation of our predictions. Our analysis also showed that m396 and 80R antibodies (against SARS-CoV-1) did not dock with RBM of SARS-CoV-2, a fact already proven experimentally. This confirmed reliability and robustness of our approach. So, it is highly probable that immunological memory/antibodies to DV in endemic countries may reduce the severity and spread of COVID-19. It is not known whether SARS-CoV-2 antibodies will hinder DV infections by binding to DV particles and reduce dengue incidences in the future or, augment DV infection and severity by deploying antibody-dependent enhancement.http://www.sciencedirect.com/science/article/pii/S2001037020305626SARS-CoV-2DengueSerodiagnosisCross-reactivityComputational docking |
| spellingShingle | Himadri Nath Abinash Mallick Subrata Roy Soumi Sukla Subhajit Biswas Computational modelling supports that dengue virus envelope antibodies can bind to SARS-CoV-2 receptor binding sites: Is pre-exposure to dengue virus protective against COVID-19 severity? Computational and Structural Biotechnology Journal SARS-CoV-2 Dengue Serodiagnosis Cross-reactivity Computational docking |
| title | Computational modelling supports that dengue virus envelope antibodies can bind to SARS-CoV-2 receptor binding sites: Is pre-exposure to dengue virus protective against COVID-19 severity? |
| title_full | Computational modelling supports that dengue virus envelope antibodies can bind to SARS-CoV-2 receptor binding sites: Is pre-exposure to dengue virus protective against COVID-19 severity? |
| title_fullStr | Computational modelling supports that dengue virus envelope antibodies can bind to SARS-CoV-2 receptor binding sites: Is pre-exposure to dengue virus protective against COVID-19 severity? |
| title_full_unstemmed | Computational modelling supports that dengue virus envelope antibodies can bind to SARS-CoV-2 receptor binding sites: Is pre-exposure to dengue virus protective against COVID-19 severity? |
| title_short | Computational modelling supports that dengue virus envelope antibodies can bind to SARS-CoV-2 receptor binding sites: Is pre-exposure to dengue virus protective against COVID-19 severity? |
| title_sort | computational modelling supports that dengue virus envelope antibodies can bind to sars cov 2 receptor binding sites is pre exposure to dengue virus protective against covid 19 severity |
| topic | SARS-CoV-2 Dengue Serodiagnosis Cross-reactivity Computational docking |
| url | http://www.sciencedirect.com/science/article/pii/S2001037020305626 |
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