Lower 123I-FP-CIT binding to the striatal dopamine transporter, but not to the extrastriatal serotonin transporter, in Parkinson's disease compared with dementia with Lewy bodies
In this retrospective cross-sectional study we compared 123I‑N‑ω‑fluoropropyl‑2β‑carbomethoxy‑3β‑(4‑iodophenyl)nortropane (123I-FP-CIT) binding to the striatal dopamine and the extrastriatal serotonin transporter (DAT and SERT, respectively) between Parkinson's disease (PD) and dementia with Le...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218301189 |
| _version_ | 1818579980503744512 |
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| author | Merijn Joling Chris Vriend Jessica J. van der Zande Afina W. Lemstra Odile A. van den Heuvel Jan Booij Henk W. Berendse |
| author_facet | Merijn Joling Chris Vriend Jessica J. van der Zande Afina W. Lemstra Odile A. van den Heuvel Jan Booij Henk W. Berendse |
| author_sort | Merijn Joling |
| collection | DOAJ |
| description | In this retrospective cross-sectional study we compared 123I‑N‑ω‑fluoropropyl‑2β‑carbomethoxy‑3β‑(4‑iodophenyl)nortropane (123I-FP-CIT) binding to the striatal dopamine and the extrastriatal serotonin transporter (DAT and SERT, respectively) between Parkinson's disease (PD) and dementia with Lewy bodies (DLB) to gain more insight in the pathophysiology of the two diseases.We compared 123I-FP-CIT single photon emission computed tomography scans of, age-, gender matched patients with cognitive decline in same range of severity with PD (n = 53) or DLB (n = 53) using a regions of interest (ROIs) approach. We derived ROIs anatomically from individual magnetic resonance imaging brain scans. To corroborate the ROI findings, we performed additional whole-brain voxel-based analyses.In both ROI and voxel-based analyses, 123I-FP-CIT binding in PD patients was significantly lower in the bilateral posterior putamen than in DLB patients (left: F(1,103) = 18.363, P < 0.001, ω2 = 0.14; right: F(1,103) = 20.434, P < 0.001, ω2 = 0.15) (Pcorr < 0.033). Caudate/putamen ratios were also significantly lower in DLB than in PD (U(105) = 724.0, P < 0.001). Extrastriatal SERT binding showed no difference between PD and DLB.These results suggest similar involvement of serotonergic structures in the degenerative process in PD and DLB. Keywords: Parkinson's disease, Dementia with Lewy bodies, 123I-FP-CIT, SERT, DAT |
| first_indexed | 2024-12-16T07:10:19Z |
| format | Article |
| id | doaj.art-748e15af4ea24d6ebb8e33a023712a6e |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-16T07:10:19Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-748e15af4ea24d6ebb8e33a023712a6e2022-12-21T22:39:55ZengElsevierNeuroImage: Clinical2213-15822018-01-0119130136Lower 123I-FP-CIT binding to the striatal dopamine transporter, but not to the extrastriatal serotonin transporter, in Parkinson's disease compared with dementia with Lewy bodiesMerijn Joling0Chris Vriend1Jessica J. van der Zande2Afina W. Lemstra3Odile A. van den Heuvel4Jan Booij5Henk W. Berendse6Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands; Department of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands; Amsterdam Neuroscience, Amsterdam, The Netherlands; Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The Netherlands; Corresponding author at: VU University Medical Center, Department of Neurology, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.Amsterdam Neuroscience, Amsterdam, The Netherlands; Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands; Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Neurology, VU University Medical Center, Amsterdam, The Netherlands; Amsterdam Neuroscience, Amsterdam, The Netherlands; Alzheimer Center, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Neurology, VU University Medical Center, Amsterdam, The Netherlands; Amsterdam Neuroscience, Amsterdam, The Netherlands; Alzheimer Center, VU University Medical Center, Amsterdam, The NetherlandsAmsterdam Neuroscience, Amsterdam, The Netherlands; Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands; Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands; Amsterdam Neuroscience, Amsterdam, The NetherlandsDepartment of Neurology, VU University Medical Center, Amsterdam, The Netherlands; Amsterdam Neuroscience, Amsterdam, The NetherlandsIn this retrospective cross-sectional study we compared 123I‑N‑ω‑fluoropropyl‑2β‑carbomethoxy‑3β‑(4‑iodophenyl)nortropane (123I-FP-CIT) binding to the striatal dopamine and the extrastriatal serotonin transporter (DAT and SERT, respectively) between Parkinson's disease (PD) and dementia with Lewy bodies (DLB) to gain more insight in the pathophysiology of the two diseases.We compared 123I-FP-CIT single photon emission computed tomography scans of, age-, gender matched patients with cognitive decline in same range of severity with PD (n = 53) or DLB (n = 53) using a regions of interest (ROIs) approach. We derived ROIs anatomically from individual magnetic resonance imaging brain scans. To corroborate the ROI findings, we performed additional whole-brain voxel-based analyses.In both ROI and voxel-based analyses, 123I-FP-CIT binding in PD patients was significantly lower in the bilateral posterior putamen than in DLB patients (left: F(1,103) = 18.363, P < 0.001, ω2 = 0.14; right: F(1,103) = 20.434, P < 0.001, ω2 = 0.15) (Pcorr < 0.033). Caudate/putamen ratios were also significantly lower in DLB than in PD (U(105) = 724.0, P < 0.001). Extrastriatal SERT binding showed no difference between PD and DLB.These results suggest similar involvement of serotonergic structures in the degenerative process in PD and DLB. Keywords: Parkinson's disease, Dementia with Lewy bodies, 123I-FP-CIT, SERT, DAThttp://www.sciencedirect.com/science/article/pii/S2213158218301189 |
| spellingShingle | Merijn Joling Chris Vriend Jessica J. van der Zande Afina W. Lemstra Odile A. van den Heuvel Jan Booij Henk W. Berendse Lower 123I-FP-CIT binding to the striatal dopamine transporter, but not to the extrastriatal serotonin transporter, in Parkinson's disease compared with dementia with Lewy bodies NeuroImage: Clinical |
| title | Lower 123I-FP-CIT binding to the striatal dopamine transporter, but not to the extrastriatal serotonin transporter, in Parkinson's disease compared with dementia with Lewy bodies |
| title_full | Lower 123I-FP-CIT binding to the striatal dopamine transporter, but not to the extrastriatal serotonin transporter, in Parkinson's disease compared with dementia with Lewy bodies |
| title_fullStr | Lower 123I-FP-CIT binding to the striatal dopamine transporter, but not to the extrastriatal serotonin transporter, in Parkinson's disease compared with dementia with Lewy bodies |
| title_full_unstemmed | Lower 123I-FP-CIT binding to the striatal dopamine transporter, but not to the extrastriatal serotonin transporter, in Parkinson's disease compared with dementia with Lewy bodies |
| title_short | Lower 123I-FP-CIT binding to the striatal dopamine transporter, but not to the extrastriatal serotonin transporter, in Parkinson's disease compared with dementia with Lewy bodies |
| title_sort | lower 123i fp cit binding to the striatal dopamine transporter but not to the extrastriatal serotonin transporter in parkinson s disease compared with dementia with lewy bodies |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218301189 |
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