Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patients
BackgroundCystatin C (CysC) levels in amyotrophic lateral sclerosis (ALS) have been found changes, however, the associations between serum CysC levels and the progression and survival of ALS remain largely unknown.MethodsA total of 1,086 ALS patients and 1,026 sex-age matched healthy controls (HCs)...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1309568/full |
| _version_ | 1827390392260100096 |
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| author | Qirui Jiang Yuan Guo Tianmi Yang Shirong Li Shirong Li Yanbing Hou Junyu Lin Yi Xiao Ruwei Ou Qianqian Wei Huifang Shang |
| author_facet | Qirui Jiang Yuan Guo Tianmi Yang Shirong Li Shirong Li Yanbing Hou Junyu Lin Yi Xiao Ruwei Ou Qianqian Wei Huifang Shang |
| author_sort | Qirui Jiang |
| collection | DOAJ |
| description | BackgroundCystatin C (CysC) levels in amyotrophic lateral sclerosis (ALS) have been found changes, however, the associations between serum CysC levels and the progression and survival of ALS remain largely unknown.MethodsA total of 1,086 ALS patients and 1,026 sex-age matched healthy controls (HCs) were enrolled in this study. Serum CysC, other renal function, and metabolic parameters were measured. Correlation analysis and binary logistic regression were used to explore the factors related to serum CysC. Kaplan–Meier curve and Cox regression model were used for survival analysis.ResultsCysC levels were significantly higher in ALS patients compared to HCs (0.94 vs. 0.85 mg/L, p < 0.001). Compared with ALS patients with lower CysC levels, those with higher CysC levels had an older age of onset, significantly lower ALSFRS-R scores (40.1 vs. 41.3, p < 0.001), a faster disease progression rate (0.75 vs. 0.67, p = 0.011), and lower frontal lobe function scores (15.8 vs. 16.1, p = 0.020). In the correlation analysis, CysC levels were significantly negatively correlated with ALSFRS-R scores (r = −0.16, p < 0.001). Additionally, ALS patients with higher CysC levels had significantly shorter survival time (40.0 vs. 51.8, p < 0.001) compared to patients with lower CysC levels. Higher CysC levels were associated with a higher risk of death in Cox analysis (HR: 1.204, 95% CI: 1.012–1.433). However, when treatment was included in the model, the result was no longer significant.ConclusionCysC levels in ALS patients were higher compared to HCs. Higher CysC levels were associated with greater disease severity, faster progression rate and shorter survival, needing early intervention. |
| first_indexed | 2024-03-08T16:52:01Z |
| format | Article |
| id | doaj.art-749087a48e564225ba95ac8b58ca174f |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-08T16:52:01Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-749087a48e564225ba95ac8b58ca174f2024-01-05T04:14:47ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-01-011710.3389/fnins.2023.13095681309568Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patientsQirui Jiang0Yuan Guo1Tianmi Yang2Shirong Li3Shirong Li4Yanbing Hou5Junyu Lin6Yi Xiao7Ruwei Ou8Qianqian Wei9Huifang Shang10Department of Neurology, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaOutpatient Department, West China School of Nursing, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurology, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurology, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, ChinaDepartment of Neurology, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurology, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurology, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurology, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurology, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurology, Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaBackgroundCystatin C (CysC) levels in amyotrophic lateral sclerosis (ALS) have been found changes, however, the associations between serum CysC levels and the progression and survival of ALS remain largely unknown.MethodsA total of 1,086 ALS patients and 1,026 sex-age matched healthy controls (HCs) were enrolled in this study. Serum CysC, other renal function, and metabolic parameters were measured. Correlation analysis and binary logistic regression were used to explore the factors related to serum CysC. Kaplan–Meier curve and Cox regression model were used for survival analysis.ResultsCysC levels were significantly higher in ALS patients compared to HCs (0.94 vs. 0.85 mg/L, p < 0.001). Compared with ALS patients with lower CysC levels, those with higher CysC levels had an older age of onset, significantly lower ALSFRS-R scores (40.1 vs. 41.3, p < 0.001), a faster disease progression rate (0.75 vs. 0.67, p = 0.011), and lower frontal lobe function scores (15.8 vs. 16.1, p = 0.020). In the correlation analysis, CysC levels were significantly negatively correlated with ALSFRS-R scores (r = −0.16, p < 0.001). Additionally, ALS patients with higher CysC levels had significantly shorter survival time (40.0 vs. 51.8, p < 0.001) compared to patients with lower CysC levels. Higher CysC levels were associated with a higher risk of death in Cox analysis (HR: 1.204, 95% CI: 1.012–1.433). However, when treatment was included in the model, the result was no longer significant.ConclusionCysC levels in ALS patients were higher compared to HCs. Higher CysC levels were associated with greater disease severity, faster progression rate and shorter survival, needing early intervention.https://www.frontiersin.org/articles/10.3389/fnins.2023.1309568/fullamyotrophic lateral sclerosiscystatin Cprognosisclinicalbiomarker |
| spellingShingle | Qirui Jiang Yuan Guo Tianmi Yang Shirong Li Shirong Li Yanbing Hou Junyu Lin Yi Xiao Ruwei Ou Qianqian Wei Huifang Shang Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patients Frontiers in Neuroscience amyotrophic lateral sclerosis cystatin C prognosis clinical biomarker |
| title | Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patients |
| title_full | Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patients |
| title_fullStr | Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patients |
| title_full_unstemmed | Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patients |
| title_short | Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patients |
| title_sort | cystatin c is associated with poor survival in amyotrophic lateral sclerosis patients |
| topic | amyotrophic lateral sclerosis cystatin C prognosis clinical biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1309568/full |
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