An association study of HLA with levofloxacin-induced severe cutaneous adverse drug reactions in Han Chinese
Summary: Levofloxacin-induced severe cutaneous adverse drug reactions (LEV-SCARs) remain unexplored. An association study of human leukocyte antigen (HLA) alleles with LEV-SCARs among 12 patients, 806 healthy subjects, and 100 levofloxacin-tolerant individuals was performed. The carrier frequencies...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223014682 |
| _version_ | 1797769781639643136 |
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| author | Menglin Jiang Jin Yang Linlin Yang Lina Wang Ting Wang Shengna Han Ye Cheng Zihua Chen Yu Su Lirong Zhang Fanping Yang Sheng-an Chen Jin Zhang Hao Xiong Lanting Wang Zhen Zhang Li Ma Xiaoqun Luo Qinghe Xing |
| author_facet | Menglin Jiang Jin Yang Linlin Yang Lina Wang Ting Wang Shengna Han Ye Cheng Zihua Chen Yu Su Lirong Zhang Fanping Yang Sheng-an Chen Jin Zhang Hao Xiong Lanting Wang Zhen Zhang Li Ma Xiaoqun Luo Qinghe Xing |
| author_sort | Menglin Jiang |
| collection | DOAJ |
| description | Summary: Levofloxacin-induced severe cutaneous adverse drug reactions (LEV-SCARs) remain unexplored. An association study of human leukocyte antigen (HLA) alleles with LEV-SCARs among 12 patients, 806 healthy subjects, and 100 levofloxacin-tolerant individuals was performed. The carrier frequencies of HLA-B∗13:01 (odds ratio [OR]: 4.50; 95% confidence interval [CI]: 1.15–17.65; p = 0.043), HLA-B∗13:02 (OR: 6.14; 95% CI: 1.73–21.76; p = 0.0072), and serotype B13 (OR: 17.73; 95% CI: 3.61–86.95; p = 4.85 × 10−5) in patients with LEV-SCARs were significantly higher than those of levofloxacin-tolerant individuals. Molecular docking analysis suggested that levofloxacin formed more stable binding models with HLA-B∗13:01 and HLA-B∗13:02 than with non-risk HLA-B∗46:01. Mass spectrometry revealed that nonapeptides bound to HLA-B∗13:02 shifted at several positions after exposure to levofloxacin. Prospective screening for serotype B13 (sensitivity: 83%, specificity: 78%) and alternative drug treatment for carriers may significantly decrease the incidence of LEV-SCARs. |
| first_indexed | 2024-03-12T21:13:57Z |
| format | Article |
| id | doaj.art-74958d9a9bd6412ba3cafefcbf05483d |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T21:13:57Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-74958d9a9bd6412ba3cafefcbf05483d2023-07-30T04:22:48ZengElsevieriScience2589-00422023-08-01268107391An association study of HLA with levofloxacin-induced severe cutaneous adverse drug reactions in Han ChineseMenglin Jiang0Jin Yang1Linlin Yang2Lina Wang3Ting Wang4Shengna Han5Ye Cheng6Zihua Chen7Yu Su8Lirong Zhang9Fanping Yang10Sheng-an Chen11Jin Zhang12Hao Xiong13Lanting Wang14Zhen Zhang15Li Ma16Xiaoqun Luo17Qinghe Xing18Children’s Hospital of Fudan University and Institutes of Biomedical Sciences of Fudan University, Shanghai 200032, ChinaDepartment of Allergy and Immunology, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, ChinaChildren’s Hospital of Fudan University and Institutes of Biomedical Sciences of Fudan University, Shanghai 200032, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, ChinaChildren’s Hospital of Fudan University and Institutes of Biomedical Sciences of Fudan University, Shanghai 200032, ChinaDepartment of Allergy and Immunology, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaChildren’s Hospital of Fudan University and Institutes of Biomedical Sciences of Fudan University, Shanghai 200032, ChinaDepartment of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Allergy and Immunology, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Allergy and Immunology, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaChildren’s Hospital of Fudan University and Institutes of Biomedical Sciences of Fudan University, Shanghai 200032, ChinaDepartment of Allergy and Immunology, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Allergy and Immunology, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Allergy and Immunology, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Allergy and Immunology, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Allergy and Immunology, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China; Corresponding authorChildren’s Hospital of Fudan University and Institutes of Biomedical Sciences of Fudan University, Shanghai 200032, China; Corresponding authorSummary: Levofloxacin-induced severe cutaneous adverse drug reactions (LEV-SCARs) remain unexplored. An association study of human leukocyte antigen (HLA) alleles with LEV-SCARs among 12 patients, 806 healthy subjects, and 100 levofloxacin-tolerant individuals was performed. The carrier frequencies of HLA-B∗13:01 (odds ratio [OR]: 4.50; 95% confidence interval [CI]: 1.15–17.65; p = 0.043), HLA-B∗13:02 (OR: 6.14; 95% CI: 1.73–21.76; p = 0.0072), and serotype B13 (OR: 17.73; 95% CI: 3.61–86.95; p = 4.85 × 10−5) in patients with LEV-SCARs were significantly higher than those of levofloxacin-tolerant individuals. Molecular docking analysis suggested that levofloxacin formed more stable binding models with HLA-B∗13:01 and HLA-B∗13:02 than with non-risk HLA-B∗46:01. Mass spectrometry revealed that nonapeptides bound to HLA-B∗13:02 shifted at several positions after exposure to levofloxacin. Prospective screening for serotype B13 (sensitivity: 83%, specificity: 78%) and alternative drug treatment for carriers may significantly decrease the incidence of LEV-SCARs.http://www.sciencedirect.com/science/article/pii/S2589004223014682Health sciencesDermatologyGeneticsImmunology |
| spellingShingle | Menglin Jiang Jin Yang Linlin Yang Lina Wang Ting Wang Shengna Han Ye Cheng Zihua Chen Yu Su Lirong Zhang Fanping Yang Sheng-an Chen Jin Zhang Hao Xiong Lanting Wang Zhen Zhang Li Ma Xiaoqun Luo Qinghe Xing An association study of HLA with levofloxacin-induced severe cutaneous adverse drug reactions in Han Chinese iScience Health sciences Dermatology Genetics Immunology |
| title | An association study of HLA with levofloxacin-induced severe cutaneous adverse drug reactions in Han Chinese |
| title_full | An association study of HLA with levofloxacin-induced severe cutaneous adverse drug reactions in Han Chinese |
| title_fullStr | An association study of HLA with levofloxacin-induced severe cutaneous adverse drug reactions in Han Chinese |
| title_full_unstemmed | An association study of HLA with levofloxacin-induced severe cutaneous adverse drug reactions in Han Chinese |
| title_short | An association study of HLA with levofloxacin-induced severe cutaneous adverse drug reactions in Han Chinese |
| title_sort | association study of hla with levofloxacin induced severe cutaneous adverse drug reactions in han chinese |
| topic | Health sciences Dermatology Genetics Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223014682 |
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