Angiocrine endothelium: from physiology to cancer
Abstract The concept of cancer as a cell-autonomous disease has been challenged by the wealth of knowledge gathered in the past decades on the importance of tumor microenvironment (TM) in cancer progression and metastasis. The significance of endothelial cells (ECs) in this scenario was initially at...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-020-02244-9 |
| _version_ | 1818459766860546048 |
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| author | Jennifer Pasquier Pegah Ghiabi Lotfi Chouchane Kais Razzouk Shahin Rafii Arash Rafii |
| author_facet | Jennifer Pasquier Pegah Ghiabi Lotfi Chouchane Kais Razzouk Shahin Rafii Arash Rafii |
| author_sort | Jennifer Pasquier |
| collection | DOAJ |
| description | Abstract The concept of cancer as a cell-autonomous disease has been challenged by the wealth of knowledge gathered in the past decades on the importance of tumor microenvironment (TM) in cancer progression and metastasis. The significance of endothelial cells (ECs) in this scenario was initially attributed to their role in vasculogenesis and angiogenesis that is critical for tumor initiation and growth. Nevertheless, the identification of endothelial-derived angiocrine factors illustrated an alternative non-angiogenic function of ECs contributing to both physiological and pathological tissue development. Gene expression profiling studies have demonstrated distinctive expression patterns in tumor-associated endothelial cells that imply a bilateral crosstalk between tumor and its endothelium. Recently, some of the molecular determinants of this reciprocal interaction have been identified which are considered as potential targets for developing novel anti-angiocrine therapeutic strategies. |
| first_indexed | 2024-12-14T23:19:35Z |
| format | Article |
| id | doaj.art-74965d177f86438a8ecda1f4140663ba |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-14T23:19:35Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-74965d177f86438a8ecda1f4140663ba2022-12-21T22:44:00ZengBMCJournal of Translational Medicine1479-58762020-02-0118111710.1186/s12967-020-02244-9Angiocrine endothelium: from physiology to cancerJennifer Pasquier0Pegah Ghiabi1Lotfi Chouchane2Kais Razzouk3Shahin Rafii4Arash Rafii5Nice Breast InstituteStem Cell & Microenvironment Laboratory, Weill Cornell Medicine-QatarDepartment of Genetic Medicine, Weill Cornell MedicineNice Breast InstituteDepartment of Genetic Medicine, Weill Cornell MedicineNice Breast InstituteAbstract The concept of cancer as a cell-autonomous disease has been challenged by the wealth of knowledge gathered in the past decades on the importance of tumor microenvironment (TM) in cancer progression and metastasis. The significance of endothelial cells (ECs) in this scenario was initially attributed to their role in vasculogenesis and angiogenesis that is critical for tumor initiation and growth. Nevertheless, the identification of endothelial-derived angiocrine factors illustrated an alternative non-angiogenic function of ECs contributing to both physiological and pathological tissue development. Gene expression profiling studies have demonstrated distinctive expression patterns in tumor-associated endothelial cells that imply a bilateral crosstalk between tumor and its endothelium. Recently, some of the molecular determinants of this reciprocal interaction have been identified which are considered as potential targets for developing novel anti-angiocrine therapeutic strategies.https://doi.org/10.1186/s12967-020-02244-9AngiocrineEndotheliumCancerCancer microenvironmentAngiogenesis |
| spellingShingle | Jennifer Pasquier Pegah Ghiabi Lotfi Chouchane Kais Razzouk Shahin Rafii Arash Rafii Angiocrine endothelium: from physiology to cancer Journal of Translational Medicine Angiocrine Endothelium Cancer Cancer microenvironment Angiogenesis |
| title | Angiocrine endothelium: from physiology to cancer |
| title_full | Angiocrine endothelium: from physiology to cancer |
| title_fullStr | Angiocrine endothelium: from physiology to cancer |
| title_full_unstemmed | Angiocrine endothelium: from physiology to cancer |
| title_short | Angiocrine endothelium: from physiology to cancer |
| title_sort | angiocrine endothelium from physiology to cancer |
| topic | Angiocrine Endothelium Cancer Cancer microenvironment Angiogenesis |
| url | https://doi.org/10.1186/s12967-020-02244-9 |
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