Protein phase separation: new insights into cell division

As the foundation for the development of multicellular organisms and the self-renewal of single cells, cell division is a highly organized event which segregates cellular components into two daughter cells equally or unequally, thus producing daughters with identical or distinct fates. Liquid-liquid...

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Main Authors: Zheng Hongdan, Wen Wenyu
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-05-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023093
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author Zheng Hongdan
Wen Wenyu
author_facet Zheng Hongdan
Wen Wenyu
author_sort Zheng Hongdan
collection DOAJ
description As the foundation for the development of multicellular organisms and the self-renewal of single cells, cell division is a highly organized event which segregates cellular components into two daughter cells equally or unequally, thus producing daughters with identical or distinct fates. Liquid-liquid phase separation (LLPS), an emerging biophysical concept, provides a new perspective for us to understand the mechanisms of a wide range of cellular events, including the organization of membrane-less organelles. Recent studies have shown that several key organelles in the cell division process are assembled into membrane-free structures via LLPS of specific proteins. Here, we summarize the regulatory functions of protein phase separation in centrosome maturation, spindle assembly and polarity establishment during cell division.
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spelling doaj.art-749949828c2546f7bd1774ecb1847f1e2023-11-06T08:35:26ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452023-05-01551042105110.3724/abbs.202309320d259ccProtein phase separation: new insights into cell divisionZheng Hongdan0Wen Wenyu1[][]As the foundation for the development of multicellular organisms and the self-renewal of single cells, cell division is a highly organized event which segregates cellular components into two daughter cells equally or unequally, thus producing daughters with identical or distinct fates. Liquid-liquid phase separation (LLPS), an emerging biophysical concept, provides a new perspective for us to understand the mechanisms of a wide range of cellular events, including the organization of membrane-less organelles. Recent studies have shown that several key organelles in the cell division process are assembled into membrane-free structures via LLPS of specific proteins. Here, we summarize the regulatory functions of protein phase separation in centrosome maturation, spindle assembly and polarity establishment during cell division.https://www.sciengine.com/doi/10.3724/abbs.2023093liquid-liquid phase separationbiomolecular condensatecell division
spellingShingle Zheng Hongdan
Wen Wenyu
Protein phase separation: new insights into cell division
Acta Biochimica et Biophysica Sinica
liquid-liquid phase separation
biomolecular condensate
cell division
title Protein phase separation: new insights into cell division
title_full Protein phase separation: new insights into cell division
title_fullStr Protein phase separation: new insights into cell division
title_full_unstemmed Protein phase separation: new insights into cell division
title_short Protein phase separation: new insights into cell division
title_sort protein phase separation new insights into cell division
topic liquid-liquid phase separation
biomolecular condensate
cell division
url https://www.sciengine.com/doi/10.3724/abbs.2023093
work_keys_str_mv AT zhenghongdan proteinphaseseparationnewinsightsintocelldivision
AT wenwenyu proteinphaseseparationnewinsightsintocelldivision