Protein phase separation: new insights into cell division
As the foundation for the development of multicellular organisms and the self-renewal of single cells, cell division is a highly organized event which segregates cellular components into two daughter cells equally or unequally, thus producing daughters with identical or distinct fates. Liquid-liquid...
Main Authors: | , |
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Format: | Article |
Language: | English |
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China Science Publishing & Media Ltd.
2023-05-01
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Series: | Acta Biochimica et Biophysica Sinica |
Subjects: | |
Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2023093 |
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author | Zheng Hongdan Wen Wenyu |
author_facet | Zheng Hongdan Wen Wenyu |
author_sort | Zheng Hongdan |
collection | DOAJ |
description | As the foundation for the development of multicellular organisms and the self-renewal of single cells, cell division is a highly organized event which segregates cellular components into two daughter cells equally or unequally, thus producing daughters with identical or distinct fates. Liquid-liquid phase separation (LLPS), an emerging biophysical concept, provides a new perspective for us to understand the mechanisms of a wide range of cellular events, including the organization of membrane-less organelles. Recent studies have shown that several key organelles in the cell division process are assembled into membrane-free structures via LLPS of specific proteins. Here, we summarize the regulatory functions of protein phase separation in centrosome maturation, spindle assembly and polarity establishment during cell division. |
first_indexed | 2024-03-11T12:26:46Z |
format | Article |
id | doaj.art-749949828c2546f7bd1774ecb1847f1e |
institution | Directory Open Access Journal |
issn | 1672-9145 |
language | English |
last_indexed | 2024-03-11T12:26:46Z |
publishDate | 2023-05-01 |
publisher | China Science Publishing & Media Ltd. |
record_format | Article |
series | Acta Biochimica et Biophysica Sinica |
spelling | doaj.art-749949828c2546f7bd1774ecb1847f1e2023-11-06T08:35:26ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452023-05-01551042105110.3724/abbs.202309320d259ccProtein phase separation: new insights into cell divisionZheng Hongdan0Wen Wenyu1[][]As the foundation for the development of multicellular organisms and the self-renewal of single cells, cell division is a highly organized event which segregates cellular components into two daughter cells equally or unequally, thus producing daughters with identical or distinct fates. Liquid-liquid phase separation (LLPS), an emerging biophysical concept, provides a new perspective for us to understand the mechanisms of a wide range of cellular events, including the organization of membrane-less organelles. Recent studies have shown that several key organelles in the cell division process are assembled into membrane-free structures via LLPS of specific proteins. Here, we summarize the regulatory functions of protein phase separation in centrosome maturation, spindle assembly and polarity establishment during cell division.https://www.sciengine.com/doi/10.3724/abbs.2023093liquid-liquid phase separationbiomolecular condensatecell division |
spellingShingle | Zheng Hongdan Wen Wenyu Protein phase separation: new insights into cell division Acta Biochimica et Biophysica Sinica liquid-liquid phase separation biomolecular condensate cell division |
title | Protein phase separation: new insights into cell division |
title_full | Protein phase separation: new insights into cell division |
title_fullStr | Protein phase separation: new insights into cell division |
title_full_unstemmed | Protein phase separation: new insights into cell division |
title_short | Protein phase separation: new insights into cell division |
title_sort | protein phase separation new insights into cell division |
topic | liquid-liquid phase separation biomolecular condensate cell division |
url | https://www.sciengine.com/doi/10.3724/abbs.2023093 |
work_keys_str_mv | AT zhenghongdan proteinphaseseparationnewinsightsintocelldivision AT wenwenyu proteinphaseseparationnewinsightsintocelldivision |