Pleiotropic activation of endothelial function by angiotensin II receptor blockers is crucial to their protective anti-vascular remodeling effects

Pleiotropic activation of endothelial function by angiotensin II receptor blockers is crucial to their protective anti-vascular remodeling effects

Abstract There are no therapeutics that directly enhance chronic endothelial nitric oxide (NO) release, which is typically associated with vascular homeostasis. In contrast, angiotensin II (AngII) receptor type 1 (AT1R) blockers (ARBs) can attenuate AngII-mediated oxidative stress, which often leads...

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Bibliographic Details
Main Authors: Arash Y. Tehrani, Zoe White, Lin Wei Tung, Roy Ru Yi Zhao, Nadia Milad, Michael A. Seidman, Elodie Sauge, Marine Theret, Fabio M. V. Rossi, Mitra Esfandiarei, Casey van Breemen, Pascal Bernatchez
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-13772-3

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