Protection of the Queuosine Biosynthesis Enzyme QueF from Irreversible Oxidation by a Conserved Intramolecular Disulfide

Protection of the Queuosine Biosynthesis Enzyme QueF from Irreversible Oxidation by a Conserved Intramolecular Disulfide

QueF enzymes catalyze the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in the biosynthetic pathway to the tRNA modified nucleoside queuosine. The QueF-catalyzed reaction includes...

Full description

Bibliographic Details
Main Authors: Adeba Mohammad, Adriana Bon Ramos, Bobby W. K. Lee, Spencer W. Cohen, Maryam K. Kiani, Dirk Iwata-Reuyl, Boguslaw Stec, Manal A. Swairjo
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Biomolecules
Subjects:
tRNA modification
oxidoreductase
tunneling fold
Online Access:http://www.mdpi.com/2218-273X/7/1/30

Internet

http://www.mdpi.com/2218-273X/7/1/30

Similar Items