The effect of π-Conjugation on the self-assembly of micelles and controlled cargo release

The effect of π-Conjugation on the self-assembly of micelles and controlled cargo release

AbstractHere we presented a novel micelle self-assembled from amphiphiles with π-conjugated moieties (OEG-DPH). The π-conjugated structural integrity of the micelles enabled stable encapsulation of Nile Red (NR, model drug). The self-assembly behaviour of the amphiphiles and the release profile of N...

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Bibliographic Details
Main Authors: Yan Liang, Yalin Sun, Xiaoheng Fu, Yang Lin, Zhu Meng, Yanan Meng, Jiping Niu, Yusi Lai, Yong Sun
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Polymeric micelle
π-π stacking interaction
self-assembly
Nile Red
drug delivery
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2020.1725028
Description
Summary:AbstractHere we presented a novel micelle self-assembled from amphiphiles with π-conjugated moieties (OEG-DPH). The π-conjugated structural integrity of the micelles enabled stable encapsulation of Nile Red (NR, model drug). The self-assembly behaviour of the amphiphiles and the release profile of NR loaded micelles were investigated. Spherical core-shell structured NR loaded micelles with low CMC of 57 μg/mL and the efficient intracellular delivery process was monitored. This research provided a way to fabricate stable polymeric micelles and develop a practical nanocarrier for therapeutics delivery.
ISSN:2169-1401
2169-141X

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