Activation of NF-kB-Mediated TNF-Induced Antimicrobial Immunity Is Required for the Efficient Brucella abortus Clearance in RAW 264.7 Cells

Activation of NF-kB-Mediated TNF-Induced Antimicrobial Immunity Is Required for the Efficient Brucella abortus Clearance in RAW 264.7 Cells

In this study, we explore the regulatory roles of pro-inflammatory cytokine tumor necrosis factor alpha (TNF) in the innate immunity of macrophages against B. abortus infection. We show that infection of macrophage with B. abortus induces marked expression and secretion of TNF which subsequently bin...

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Bibliographic Details
Main Authors: Huynh T. Hop, Alisha W. B. Reyes, Tran X. N. Huy, Lauren T. Arayan, WonGi Min, Hu J. Lee, Man H. Rhee, Hong H. Chang, Suk Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
B. abortus
TNF
TNFR-1
ROS
NO
NF-kB transcriptional factor
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00437/full

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