The Role and Mechanism of <i>Perilla frutescens</i> in Cancer Treatment
<i>Perilla frutescens</i> is an annual herb of the Labiatae family and is widely grown in several countries in Asia. <i>Perilla frutescens</i> is a plant that is used medicinally in its entirety, as seen in its subdivision into perilla seeds, perilla stalks, and perilla leave...
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MDPI AG
2023-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/15/5883 |
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| author | Shicong Huang Yi Nan Guoqing Chen Na Ning Yuhua Du Doudou Lu Yating Yang Fandi Meng Ling Yuan |
| author_facet | Shicong Huang Yi Nan Guoqing Chen Na Ning Yuhua Du Doudou Lu Yating Yang Fandi Meng Ling Yuan |
| author_sort | Shicong Huang |
| collection | DOAJ |
| description | <i>Perilla frutescens</i> is an annual herb of the Labiatae family and is widely grown in several countries in Asia. <i>Perilla frutescens</i> is a plant that is used medicinally in its entirety, as seen in its subdivision into perilla seeds, perilla stalks, and perilla leaves, which vary more markedly in their chemical composition. Several studies have shown that <i>Perilla frutescens</i> has a variety of pharmacological effects, including anti-inflammatory, antibacterial, detoxifying, antioxidant, and hepatoprotective. In the absence of a review of <i>Perilla frutescens</i> for the treatment of cancer. This review provides an overview of the chemical composition and molecular mechanisms of <i>Perilla frutescens</i> for cancer treatment. It was found that the main active components of <i>Perilla frutescens</i> producing cancer therapeutic effects were perilla aldehyde (PAH), rosmarinic acid (Ros A), lignan, and isoestrogen (IK). In addition to these, extracts of the leaves and fruits of <i>Perilla frutescens</i> are also included. Among these, perilla seed oil (PSO) has a preventive effect against colorectal cancer due to the presence of omega-3 polyunsaturated fatty acids. This review also provides new ideas and thoughts for scientific innovation and clinical applications related to <i>Perilla frutescens</i>. |
| first_indexed | 2024-03-11T00:20:35Z |
| format | Article |
| id | doaj.art-74a4142948e04a02b0df4ba57918d00c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:20:35Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-74a4142948e04a02b0df4ba57918d00c2023-11-18T23:20:07ZengMDPI AGMolecules1420-30492023-08-012815588310.3390/molecules28155883The Role and Mechanism of <i>Perilla frutescens</i> in Cancer TreatmentShicong Huang0Yi Nan1Guoqing Chen2Na Ning3Yuhua Du4Doudou Lu5Yating Yang6Fandi Meng7Ling Yuan8College of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaCollege of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaCollege of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaCollege of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaCollege of Pharmacy, Ningxia Medical University, Yinchuan 750004, ChinaClinical Medical School, Ningxia Medical University, Yinchuan 750004, ChinaInstitute of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750004, ChinaInstitute of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan 750004, ChinaCollege of Pharmacy, Ningxia Medical University, Yinchuan 750004, China<i>Perilla frutescens</i> is an annual herb of the Labiatae family and is widely grown in several countries in Asia. <i>Perilla frutescens</i> is a plant that is used medicinally in its entirety, as seen in its subdivision into perilla seeds, perilla stalks, and perilla leaves, which vary more markedly in their chemical composition. Several studies have shown that <i>Perilla frutescens</i> has a variety of pharmacological effects, including anti-inflammatory, antibacterial, detoxifying, antioxidant, and hepatoprotective. In the absence of a review of <i>Perilla frutescens</i> for the treatment of cancer. This review provides an overview of the chemical composition and molecular mechanisms of <i>Perilla frutescens</i> for cancer treatment. It was found that the main active components of <i>Perilla frutescens</i> producing cancer therapeutic effects were perilla aldehyde (PAH), rosmarinic acid (Ros A), lignan, and isoestrogen (IK). In addition to these, extracts of the leaves and fruits of <i>Perilla frutescens</i> are also included. Among these, perilla seed oil (PSO) has a preventive effect against colorectal cancer due to the presence of omega-3 polyunsaturated fatty acids. This review also provides new ideas and thoughts for scientific innovation and clinical applications related to <i>Perilla frutescens</i>.https://www.mdpi.com/1420-3049/28/15/5883<i>Perilla frutescens</i>active ingredienttumormechanism |
| spellingShingle | Shicong Huang Yi Nan Guoqing Chen Na Ning Yuhua Du Doudou Lu Yating Yang Fandi Meng Ling Yuan The Role and Mechanism of <i>Perilla frutescens</i> in Cancer Treatment Molecules <i>Perilla frutescens</i> active ingredient tumor mechanism |
| title | The Role and Mechanism of <i>Perilla frutescens</i> in Cancer Treatment |
| title_full | The Role and Mechanism of <i>Perilla frutescens</i> in Cancer Treatment |
| title_fullStr | The Role and Mechanism of <i>Perilla frutescens</i> in Cancer Treatment |
| title_full_unstemmed | The Role and Mechanism of <i>Perilla frutescens</i> in Cancer Treatment |
| title_short | The Role and Mechanism of <i>Perilla frutescens</i> in Cancer Treatment |
| title_sort | role and mechanism of i perilla frutescens i in cancer treatment |
| topic | <i>Perilla frutescens</i> active ingredient tumor mechanism |
| url | https://www.mdpi.com/1420-3049/28/15/5883 |
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