Mild COVID-19 infection associated with post-COVID-19 condition after 3 months – a questionnaire survey
AbstractIntroduction The coronavirus disease 2019 (COVID-19), caused by infection with SARS-CoV-2, can lead to post-COVID-19 condition, a secondary syndrome of persistent and new post-acute symptoms, but evidence on this syndrome is still scarce.Methods In a questionnaire survey, residents of the ci...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2226907 |
| _version_ | 1797353740655656960 |
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| author | Stefan Rach Lisa Kühne Hajo Zeeb Wolfgang Ahrens Ulrike Haug Hermann Pohlabeln |
| author_facet | Stefan Rach Lisa Kühne Hajo Zeeb Wolfgang Ahrens Ulrike Haug Hermann Pohlabeln |
| author_sort | Stefan Rach |
| collection | DOAJ |
| description | AbstractIntroduction The coronavirus disease 2019 (COVID-19), caused by infection with SARS-CoV-2, can lead to post-COVID-19 condition, a secondary syndrome of persistent and new post-acute symptoms, but evidence on this syndrome is still scarce.Methods In a questionnaire survey, residents of the city of Bremen (Germany) with verified SARS-CoV-2 infection were invited to answer questions (online questionnaire or interview) concerning symptoms experienced at the time of infection and at the time of questionnaire completion at least three months later. Main outcome of the analysis was the presence of a post-COVID-19 condition at the time of the interview, defined as the presence of at least two of three leading symptoms: fatigue, breathing difficulties, or cognitive problems.Results A post-COVID-19 condition was more likely to be reported if respondents had, at the time of infection, suffered from fatigue (OR 1.75; 95% CI: 1.00, 3.06), breathing difficulties (OR 4.02; 95% CI: 2.80, 5.77), cognitive symptoms (OR 2.98; 95% CI: 1.48, 6.02), or head- & bone aches (OR 2.06; 95% CI: 1.25, 3.42). The odds of developing a post-COVID-19 condition increased with the number of symptoms at infection. Females were more likely to report a post-COVID-19 condition (OR 1.54; 95% CI: 1.05, 2.24). Analyzing only non-hospitalized respondents changed results only slightly.Conclusion Our study adds to growing evidence that even a mild course of COVID-19 poses a risk for developing a post-COVID-19 condition. Females and those with initial symptoms including fatigue, breathing difficulties, and cognitive symptoms seem more likely to also experience post COVID-19 symptoms several months after infection.KEY MESSAGESEven a mild course of COVID-19 poses a risk for developing a post-COVID-19 condition.Females seem more likely to develop a post-COVID-19 condition.Those with initial symptoms including fatigue, breathing difficulties, and cognitive symptoms seem more likely to develop a post-COVID-19 condition. |
| first_indexed | 2024-03-08T13:35:26Z |
| format | Article |
| id | doaj.art-74a47edb875f4f22a7ef97d08fc88f20 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:35:26Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-74a47edb875f4f22a7ef97d08fc88f202024-01-16T19:13:21ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155110.1080/07853890.2023.2226907Mild COVID-19 infection associated with post-COVID-19 condition after 3 months – a questionnaire surveyStefan Rach0Lisa Kühne1Hajo Zeeb2Wolfgang Ahrens3Ulrike Haug4Hermann Pohlabeln5Leibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, GermanyLeibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, GermanyLeibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, GermanyLeibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, GermanyLeibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, GermanyLeibniz Institute for Prevention Research and Epidemiology – BIPS, Bremen, GermanyAbstractIntroduction The coronavirus disease 2019 (COVID-19), caused by infection with SARS-CoV-2, can lead to post-COVID-19 condition, a secondary syndrome of persistent and new post-acute symptoms, but evidence on this syndrome is still scarce.Methods In a questionnaire survey, residents of the city of Bremen (Germany) with verified SARS-CoV-2 infection were invited to answer questions (online questionnaire or interview) concerning symptoms experienced at the time of infection and at the time of questionnaire completion at least three months later. Main outcome of the analysis was the presence of a post-COVID-19 condition at the time of the interview, defined as the presence of at least two of three leading symptoms: fatigue, breathing difficulties, or cognitive problems.Results A post-COVID-19 condition was more likely to be reported if respondents had, at the time of infection, suffered from fatigue (OR 1.75; 95% CI: 1.00, 3.06), breathing difficulties (OR 4.02; 95% CI: 2.80, 5.77), cognitive symptoms (OR 2.98; 95% CI: 1.48, 6.02), or head- & bone aches (OR 2.06; 95% CI: 1.25, 3.42). The odds of developing a post-COVID-19 condition increased with the number of symptoms at infection. Females were more likely to report a post-COVID-19 condition (OR 1.54; 95% CI: 1.05, 2.24). Analyzing only non-hospitalized respondents changed results only slightly.Conclusion Our study adds to growing evidence that even a mild course of COVID-19 poses a risk for developing a post-COVID-19 condition. Females and those with initial symptoms including fatigue, breathing difficulties, and cognitive symptoms seem more likely to also experience post COVID-19 symptoms several months after infection.KEY MESSAGESEven a mild course of COVID-19 poses a risk for developing a post-COVID-19 condition.Females seem more likely to develop a post-COVID-19 condition.Those with initial symptoms including fatigue, breathing difficulties, and cognitive symptoms seem more likely to develop a post-COVID-19 condition.https://www.tandfonline.com/doi/10.1080/07853890.2023.2226907SARS-CoV-2COVID-19post-COVID-19 conditionLong COVIDcross-sectionalpopulation-based |
| spellingShingle | Stefan Rach Lisa Kühne Hajo Zeeb Wolfgang Ahrens Ulrike Haug Hermann Pohlabeln Mild COVID-19 infection associated with post-COVID-19 condition after 3 months – a questionnaire survey Annals of Medicine SARS-CoV-2 COVID-19 post-COVID-19 condition Long COVID cross-sectional population-based |
| title | Mild COVID-19 infection associated with post-COVID-19 condition after 3 months – a questionnaire survey |
| title_full | Mild COVID-19 infection associated with post-COVID-19 condition after 3 months – a questionnaire survey |
| title_fullStr | Mild COVID-19 infection associated with post-COVID-19 condition after 3 months – a questionnaire survey |
| title_full_unstemmed | Mild COVID-19 infection associated with post-COVID-19 condition after 3 months – a questionnaire survey |
| title_short | Mild COVID-19 infection associated with post-COVID-19 condition after 3 months – a questionnaire survey |
| title_sort | mild covid 19 infection associated with post covid 19 condition after 3 months a questionnaire survey |
| topic | SARS-CoV-2 COVID-19 post-COVID-19 condition Long COVID cross-sectional population-based |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2226907 |
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