Phage Therapy: Towards a Successful Clinical Trial
While phage therapy carried out as compassionate use (experimental therapy) has recently flourished, providing numerous case reports of supposedly healed patients, clinical trials aiming to formally prove their value in accord with current regulatory requirements have failed. In light of the current...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/9/11/827 |
| _version_ | 1797547491656204288 |
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| author | Andrzej Górski Jan Borysowski Ryszard Międzybrodzki |
| author_facet | Andrzej Górski Jan Borysowski Ryszard Międzybrodzki |
| author_sort | Andrzej Górski |
| collection | DOAJ |
| description | While phage therapy carried out as compassionate use (experimental therapy) has recently flourished, providing numerous case reports of supposedly healed patients, clinical trials aiming to formally prove their value in accord with current regulatory requirements have failed. In light of the current issue of increasing antibiotic resistance, the need for a final say regarding the place of phage therapy in modern medicine is evident. We analyze the possible factors that may favor success or lead to the failure of phage therapy: quality of phage preparations, their titer and dosage, as well as external factors that could also contribute to the outcome of phage therapy. Hopefully, better control of these factors may eventually bring about long-awaited positive results. |
| first_indexed | 2024-03-10T14:44:51Z |
| format | Article |
| id | doaj.art-74a4a301ec344fe18b0fdf2deb042205 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T14:44:51Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-74a4a301ec344fe18b0fdf2deb0422052023-11-20T21:29:22ZengMDPI AGAntibiotics2079-63822020-11-0191182710.3390/antibiotics9110827Phage Therapy: Towards a Successful Clinical TrialAndrzej Górski0Jan Borysowski1Ryszard Międzybrodzki2Bacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wroclaw, PolandDepartment of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, 02-006 Warsaw, PolandBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114 Wroclaw, PolandWhile phage therapy carried out as compassionate use (experimental therapy) has recently flourished, providing numerous case reports of supposedly healed patients, clinical trials aiming to formally prove their value in accord with current regulatory requirements have failed. In light of the current issue of increasing antibiotic resistance, the need for a final say regarding the place of phage therapy in modern medicine is evident. We analyze the possible factors that may favor success or lead to the failure of phage therapy: quality of phage preparations, their titer and dosage, as well as external factors that could also contribute to the outcome of phage therapy. Hopefully, better control of these factors may eventually bring about long-awaited positive results.https://www.mdpi.com/2079-6382/9/11/827phage therapyclinical trialantibiotic resistance |
| spellingShingle | Andrzej Górski Jan Borysowski Ryszard Międzybrodzki Phage Therapy: Towards a Successful Clinical Trial Antibiotics phage therapy clinical trial antibiotic resistance |
| title | Phage Therapy: Towards a Successful Clinical Trial |
| title_full | Phage Therapy: Towards a Successful Clinical Trial |
| title_fullStr | Phage Therapy: Towards a Successful Clinical Trial |
| title_full_unstemmed | Phage Therapy: Towards a Successful Clinical Trial |
| title_short | Phage Therapy: Towards a Successful Clinical Trial |
| title_sort | phage therapy towards a successful clinical trial |
| topic | phage therapy clinical trial antibiotic resistance |
| url | https://www.mdpi.com/2079-6382/9/11/827 |
| work_keys_str_mv | AT andrzejgorski phagetherapytowardsasuccessfulclinicaltrial AT janborysowski phagetherapytowardsasuccessfulclinicaltrial AT ryszardmiedzybrodzki phagetherapytowardsasuccessfulclinicaltrial |