Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases
As brain and bone disorders represent major health issues worldwide, substantial clinical investigations demonstrated a bidirectional crosstalk on several levels, mechanistically linking both apparently unrelated organs. While multiple stress, mood and neurodegenerative brain disorders are associate...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/14/4946 |
| _version_ | 1797562536760967168 |
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| author | Ellen Otto Paul-Richard Knapstein Denise Jahn Jessika Appelt Karl-Heinz Frosch Serafeim Tsitsilonis Johannes Keller |
| author_facet | Ellen Otto Paul-Richard Knapstein Denise Jahn Jessika Appelt Karl-Heinz Frosch Serafeim Tsitsilonis Johannes Keller |
| author_sort | Ellen Otto |
| collection | DOAJ |
| description | As brain and bone disorders represent major health issues worldwide, substantial clinical investigations demonstrated a bidirectional crosstalk on several levels, mechanistically linking both apparently unrelated organs. While multiple stress, mood and neurodegenerative brain disorders are associated with osteoporosis, rare genetic skeletal diseases display impaired brain development and function. Along with brain and bone pathologies, particularly trauma events highlight the strong interaction of both organs. This review summarizes clinical and experimental observations reported for the crosstalk of brain and bone, followed by a detailed overview of their molecular bases. While brain-derived molecules affecting bone include central regulators, transmitters of the sympathetic, parasympathetic and sensory nervous system, bone-derived mediators altering brain function are released from bone cells and the bone marrow. Although the main pathways of the brain-bone crosstalk remain ‘efferent’, signaling from brain to bone, this review emphasizes the emergence of bone as a crucial ‘afferent’ regulator of cerebral development, function and pathophysiology. Therefore, unraveling the physiological and pathological bases of brain-bone interactions revealed promising pharmacologic targets and novel treatment strategies promoting concurrent brain and bone recovery. |
| first_indexed | 2024-03-10T18:30:37Z |
| format | Article |
| id | doaj.art-74a4ddf08ae9490194435ed082acdbef |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:30:37Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-74a4ddf08ae9490194435ed082acdbef2023-11-20T06:39:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012114494610.3390/ijms21144946Crosstalk of Brain and Bone—Clinical Observations and Their Molecular BasesEllen Otto0Paul-Richard Knapstein1Denise Jahn2Jessika Appelt3Karl-Heinz Frosch4Serafeim Tsitsilonis5Johannes Keller6Julius Wolff Institute for Biomechanics and Musculoskeletal Regeneration, Charité-Universitätsmedizin Berlin, 13353 Berlin, GermanyClinic of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyJulius Wolff Institute for Biomechanics and Musculoskeletal Regeneration, Charité-Universitätsmedizin Berlin, 13353 Berlin, GermanyJulius Wolff Institute for Biomechanics and Musculoskeletal Regeneration, Charité-Universitätsmedizin Berlin, 13353 Berlin, GermanyClinic of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyJulius Wolff Institute for Biomechanics and Musculoskeletal Regeneration, Charité-Universitätsmedizin Berlin, 13353 Berlin, GermanyClinic of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyAs brain and bone disorders represent major health issues worldwide, substantial clinical investigations demonstrated a bidirectional crosstalk on several levels, mechanistically linking both apparently unrelated organs. While multiple stress, mood and neurodegenerative brain disorders are associated with osteoporosis, rare genetic skeletal diseases display impaired brain development and function. Along with brain and bone pathologies, particularly trauma events highlight the strong interaction of both organs. This review summarizes clinical and experimental observations reported for the crosstalk of brain and bone, followed by a detailed overview of their molecular bases. While brain-derived molecules affecting bone include central regulators, transmitters of the sympathetic, parasympathetic and sensory nervous system, bone-derived mediators altering brain function are released from bone cells and the bone marrow. Although the main pathways of the brain-bone crosstalk remain ‘efferent’, signaling from brain to bone, this review emphasizes the emergence of bone as a crucial ‘afferent’ regulator of cerebral development, function and pathophysiology. Therefore, unraveling the physiological and pathological bases of brain-bone interactions revealed promising pharmacologic targets and novel treatment strategies promoting concurrent brain and bone recovery.https://www.mdpi.com/1422-0067/21/14/4946brainboneinteractionclinical and experimental studiesmolecular signaling |
| spellingShingle | Ellen Otto Paul-Richard Knapstein Denise Jahn Jessika Appelt Karl-Heinz Frosch Serafeim Tsitsilonis Johannes Keller Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases International Journal of Molecular Sciences brain bone interaction clinical and experimental studies molecular signaling |
| title | Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases |
| title_full | Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases |
| title_fullStr | Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases |
| title_full_unstemmed | Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases |
| title_short | Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases |
| title_sort | crosstalk of brain and bone clinical observations and their molecular bases |
| topic | brain bone interaction clinical and experimental studies molecular signaling |
| url | https://www.mdpi.com/1422-0067/21/14/4946 |
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