Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases

Crosstalk of Brain and Bone—Clinical Observations and Their Molecular Bases

As brain and bone disorders represent major health issues worldwide, substantial clinical investigations demonstrated a bidirectional crosstalk on several levels, mechanistically linking both apparently unrelated organs. While multiple stress, mood and neurodegenerative brain disorders are associate...

Full description

Bibliographic Details
Main Authors:	Ellen Otto, Paul-Richard Knapstein, Denise Jahn, Jessika Appelt, Karl-Heinz Frosch, Serafeim Tsitsilonis, Johannes Keller
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Series:	International Journal of Molecular Sciences
Subjects:	brain bone interaction clinical and experimental studies molecular signaling
Online Access:	https://www.mdpi.com/1422-0067/21/14/4946

Similar Items

Tranexamic Acid Promotes Murine Bone Marrow-Derived Osteoblast Proliferation and Inhibits Osteoclast Formation In Vitro
by: Anke Baranowsky, et al.
Published: (2021-01-01)

Mice Lacking the Calcitonin Receptor Do Not Display Improved Bone Healing
by: Jessika Appelt, et al.
Published: (2021-09-01)

The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing
by: Jessika Appelt, et al.
Published: (2020-09-01)

Future Perspectives in Spinal Cord Repair: Brain as Saviour? TSCI with Concurrent TBI: Pathophysiological Interaction and Impact on MSC Treatment
by: Paul Köhli, et al.
Published: (2021-10-01)

The calcitonin receptor protects against bone loss and excessive inflammation in collagen antibody-induced arthritis
by: Tazio Maleitzke, et al.
Published: (2022-01-01)

Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment
by: Anke Baranowsky, et al.
Published: (2022-01-01)

Leptin Mediated Pathways Stabilize Posttraumatic Insulin and Osteocalcin Patterns after Long Bone Fracture and Concomitant Traumatic Brain Injury and Thus Influence Fracture Healing in a Combined Murine Trauma Model
by: Anja Garbe, et al.
Published: (2020-11-01)

An optimized protocol for a standardized, femoral osteotomy model to study fracture healing in mice
by: Shan Jiang, et al.
Published: (2021-09-01)

Relevance of Notch Signaling for Bone Metabolism and Regeneration
by: Tobias M. Ballhause, et al.
Published: (2021-01-01)

Bone and brain metastases : advances in research and treatment /
by: Sahgal, Arjun, 1974-, et al.
Published: (2010)

The selective norepinephrine reuptake inhibitor reboxetine promotes late-stage fracture healing in mice
by: Antonia Donat, et al.
Published: (2023-10-01)

Muscle–Bone Crosstalk: Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies
by: Delphine B. Maurel, et al.
Published: (2017-10-01)

Editorial: Crosstalk between bone and other cells
by: Narattaphol Charoenphandhu, et al.
Published: (2023-05-01)

Callus formation in bone fractures combined with brain injury in rat
by: Yu-Ping Chen, et al.
Published: (2017-01-01)

Bone circuitry and interorgan skeletal crosstalk
by: Mone Zaidi, et al.
Published: (2023-01-01)

Identification of Sclerostin as a Putative New Myokine Involved in the Muscle-to-Bone Crosstalk
by: Maria Sara Magarò, et al.
Published: (2021-01-01)

Exercise improves subchondral bone microenvironment through regulating bone-cartilage crosstalk
by: Shihua Zhang, et al.
Published: (2023-05-01)

The Diagnostic Challenge of Osteoid Osteoma in the Bones of the Hand—A Case Series
by: Jasmin Meyer, et al.
Published: (2023-03-01)

Importance of Sclerostin as Bone-Muscle Mediator Crosstalk
by: I Gusti Putu Suka Aryana, et al.
Published: (2022-06-01)

Crosstalk between Bone and Nerves within Bone
by: Qian‐Qian Wan, et al.
Published: (2021-04-01)

PRECLINICAL STUDIES ON PLEIOTROPIC FUNCTIONS OF ERYTHROPOIETIN ON BONE HEALING
by: R. Vasileva, et al.
Published: (2021-03-01)

Impact of simultaneous placement of implant and block bone graft substitute: an in vivo peri-implant defect model
by: Minh Khai Le Thieu, et al.
Published: (2021-11-01)

Improved Low-Frequency Crosstalk Cancellation in Bone Conduction Using Bone Transducers and Probe Microphone
by: Irwansyah, et al.
Published: (2022-01-01)

Bone-Derived Modulators That Regulate Brain Function: Emerging Therapeutic Targets for Neurological Disorders
by: Hongzhen Chen, et al.
Published: (2021-06-01)

The dual pro-inflammatory and bone-protective role of calcitonin gene-related peptide alpha in age-related osteoarthritis
by: Alexander Hildebrandt, et al.
Published: (2023-12-01)

Organ crosstalk mapping: The role of muscle-bone crosstalk in modulating diabesity-induced muscle and bone complications
by: Hamid Alizadeh
Published: (2022-09-01)

Integrative assessment of brain and bone invasion in meningioma patients
by: Kerstin Zwirner, et al.
Published: (2019-07-01)

Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions
by: Sonja Buvinic, et al.
Published: (2021-03-01)

Macrophages—bone marrow mesenchymal stem cells crosstalk in bone healing
by: Siyu Fan, et al.
Published: (2023-06-01)

QUANTITATIVE EVALUATION OF EXPERIMENTAL BONE REGENERATION USING INDENTATION TESTS
by: Valéria Trombini Vidotto, et al.
Published: (2017-04-01)

Obesity and Brain Function: The Brain–Body Crosstalk
by: Sophia X. Sui, et al.
Published: (2020-09-01)

Aging brain: exploring the interplay between bone marrow aging, immunosenescence, and neuroinflammation
by: Ludmila Müller, et al.
Published: (2024-04-01)

Metabolic crosstalk between stromal and malignant cells in the bone marrow niche
by: Hernán A. Tirado, et al.
Published: (2023-06-01)

Ultrastructural changes of bone marrow cells exposed for xenogenous cerebrospinal fluid
by: Shaymardanova L.R.
Published: (2010-01-01)

Bone Marrow Derived Extracellular Vesicles Activate Osteoclast Differentiation in Traumatic Brain Injury Induced Bone Loss
by: Quante Singleton, et al.
Published: (2019-01-01)

Understanding the Impact of Trampling on Rodent Bones
by: Yolanda Fernández-Jalvo, et al.
Published: (2022-02-01)

Brain schistosomiasis in mice experimentally infected with Schistosoma mansoni
by: José Roberto Lambertucci, et al.
Published: (2014-05-01)

Brain Crosstalk with Other Organs in ICU Patient
by: Sai Saran, et al.
Published: (2019-09-01)

Histologic and histomorphometric evaluation of the effect of lactoferrin combined with anorganic bovine bone on healing of experimentally induced bony defects on rabbit calvaria
by: Mojgan Paknejad, et al.
Published: (2012-01-01)

Editorial: Osteoporosis, sarcopenia and muscle-bone crosstalk in COPD
by: Yongchang Sun, et al.
Published: (2022-10-01)