Stage-specific regulation of signalling pathways to differentiate pluripotent stem cells to cardiomyocytes with ventricular lineage

Stage-specific regulation of signalling pathways to differentiate pluripotent stem cells to cardiomyocytes with ventricular lineage

Abstract Background Pluripotent stem cells (PSCs) can be an ideal source of differentiation of cardiomyocytes in vitro and during transplantation to induce cardiac regeneration. However, differentiation of PSCs into a heterogeneous population is associated with an increased incidence of arrhythmia f...

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Bibliographic Details
Main Authors: Ramakanth Satthenapalli, Scott Lee, Jayanthi Bellae Papannarao, Timothy A. Hore, Akash Chakraborty, Peter P. Jones, Regis R. Lamberts, Rajesh Katare
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Stem Cell Research & Therapy
Subjects:
Embryonic stem cells
Ventricular cardiomyocytes
Wnt signalling
Retinoic acid inhibition
Embryoid bodies
Online Access:https://doi.org/10.1186/s13287-022-02845-9

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