Endoscopic Characteristics of Rugal Hyperplasia and Related Acid Condition in Helicobacter pylori-Infected Stomach
Background/Aims Rugal hyperplastic gastritis (RHG) is associated with Lauren’s diffuse-type gastric cancer (GC) and the accompanying active inflammation is linked to gastric hypoacidity. We tried to establish the steps for identifying high-risk GC patients. Methods We included 196 patients with conf...
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| Format: | Article |
| Language: | English |
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Korean Society of Gastrointestinal Endoscopy
2021-01-01
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| Series: | Clinical Endoscopy |
| Subjects: | |
| Online Access: | http://www.e-ce.org/upload/pdf/ce-2020-020.pdf |
| _version_ | 1797428092594028544 |
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| author | Byung Chul Kim Mi Ae Song Sung Ho Kwon |
| author_facet | Byung Chul Kim Mi Ae Song Sung Ho Kwon |
| author_sort | Byung Chul Kim |
| collection | DOAJ |
| description | Background/Aims Rugal hyperplastic gastritis (RHG) is associated with Lauren’s diffuse-type gastric cancer (GC) and the accompanying active inflammation is linked to gastric hypoacidity. We tried to establish the steps for identifying high-risk GC patients. Methods We included 196 patients with confirmed Helicobacter pylori infection by rapid urease test during screening endoscopy for health check-up from January 2016 to September 2016; all patients underwent blood tests for pepsinogen I and II and fasting serum gastrin. We compared RHG findings with various other endoscopic mucosal images. We also evaluated the relationships between RHG and other mucosal aspects for a given acid status based on serological markers. Results Hypoacid and ultra-low-acid (67%) statuses were dominant, with only 18% hyperacid patients. RHG with high acid was related to a less atrophic body type (p=0.001), and RHG with ultra-low acid was associated with body xanthoma (p=0.029) and increased serum gastrin level (p=0.038). However, RHG’s influence on gastric acidity was only seen in closed-type endoscopic atrophic border (EAB), not in open type (p=0.001). Conclusions The majority of RHG patients had hypoacid status. RHG frequency showed no difference between closed and opentype EAB, but gastric acidity was influenced by RHG only in closed-type EAB. |
| first_indexed | 2024-03-09T08:54:12Z |
| format | Article |
| id | doaj.art-74a5d57122b74b2e803c2392918799d0 |
| institution | Directory Open Access Journal |
| issn | 2234-2400 2234-2443 |
| language | English |
| last_indexed | 2024-03-09T08:54:12Z |
| publishDate | 2021-01-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj.art-74a5d57122b74b2e803c2392918799d02023-12-02T13:38:58ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432021-01-01541738410.5946/ce.2020.0207452Endoscopic Characteristics of Rugal Hyperplasia and Related Acid Condition in Helicobacter pylori-Infected StomachByung Chul Kim0Mi Ae Song1Sung Ho Kwon2 Department of Internal Medicine, Hangsarang Hospital, Ulsan, Korea Department of Internal Medicine, Hangsarang Hospital, Ulsan, Korea Department of Internal Medicine, Kangnam Medical Clinic, Ulsan, KoreaBackground/Aims Rugal hyperplastic gastritis (RHG) is associated with Lauren’s diffuse-type gastric cancer (GC) and the accompanying active inflammation is linked to gastric hypoacidity. We tried to establish the steps for identifying high-risk GC patients. Methods We included 196 patients with confirmed Helicobacter pylori infection by rapid urease test during screening endoscopy for health check-up from January 2016 to September 2016; all patients underwent blood tests for pepsinogen I and II and fasting serum gastrin. We compared RHG findings with various other endoscopic mucosal images. We also evaluated the relationships between RHG and other mucosal aspects for a given acid status based on serological markers. Results Hypoacid and ultra-low-acid (67%) statuses were dominant, with only 18% hyperacid patients. RHG with high acid was related to a less atrophic body type (p=0.001), and RHG with ultra-low acid was associated with body xanthoma (p=0.029) and increased serum gastrin level (p=0.038). However, RHG’s influence on gastric acidity was only seen in closed-type endoscopic atrophic border (EAB), not in open type (p=0.001). Conclusions The majority of RHG patients had hypoacid status. RHG frequency showed no difference between closed and opentype EAB, but gastric acidity was influenced by RHG only in closed-type EAB.http://www.e-ce.org/upload/pdf/ce-2020-020.pdfgastric acidgastritis |
| spellingShingle | Byung Chul Kim Mi Ae Song Sung Ho Kwon Endoscopic Characteristics of Rugal Hyperplasia and Related Acid Condition in Helicobacter pylori-Infected Stomach Clinical Endoscopy gastric acid gastritis |
| title | Endoscopic Characteristics of Rugal Hyperplasia and Related Acid Condition in Helicobacter pylori-Infected Stomach |
| title_full | Endoscopic Characteristics of Rugal Hyperplasia and Related Acid Condition in Helicobacter pylori-Infected Stomach |
| title_fullStr | Endoscopic Characteristics of Rugal Hyperplasia and Related Acid Condition in Helicobacter pylori-Infected Stomach |
| title_full_unstemmed | Endoscopic Characteristics of Rugal Hyperplasia and Related Acid Condition in Helicobacter pylori-Infected Stomach |
| title_short | Endoscopic Characteristics of Rugal Hyperplasia and Related Acid Condition in Helicobacter pylori-Infected Stomach |
| title_sort | endoscopic characteristics of rugal hyperplasia and related acid condition in helicobacter pylori infected stomach |
| topic | gastric acid gastritis |
| url | http://www.e-ce.org/upload/pdf/ce-2020-020.pdf |
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