Antiviral and Antiproliferative Potential of Marine Organisms From the Yucatan Peninsula, Mexico
Viral infections are one of the main human health problems in recent decades and the cancer remains one of the most lethal diseases worldwide. The development of new antiviral drugs for the treatment of human adenovirus (HAdV) infections continues to be a challenging goal for medicinal chemistry. Th...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-08-01
|
| Series: | Frontiers in Marine Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmars.2020.00607/full |
| _version_ | 1811209228158763008 |
|---|---|
| author | Dawrin Pech-Puch Judith Berastegui-Cabrera Mar Pérez-Povedano Harold Villegas-Hernández Sergio Guillén-Hernández Bastien Cautain Fernando Reyes Jerónimo Pachón Patricia Gómez Jaime Rodríguez Carlos Jiménez Javier Sánchez-Céspedes |
| author_facet | Dawrin Pech-Puch Judith Berastegui-Cabrera Mar Pérez-Povedano Harold Villegas-Hernández Sergio Guillén-Hernández Bastien Cautain Fernando Reyes Jerónimo Pachón Patricia Gómez Jaime Rodríguez Carlos Jiménez Javier Sánchez-Céspedes |
| author_sort | Dawrin Pech-Puch |
| collection | DOAJ |
| description | Viral infections are one of the main human health problems in recent decades and the cancer remains one of the most lethal diseases worldwide. The development of new antiviral drugs for the treatment of human adenovirus (HAdV) infections continues to be a challenging goal for medicinal chemistry. There is no specific antiviral drug approved to treat infections caused by HAdV so far and the off-label treatments currently available show great variability in their effectiveness. In relation to cancer, most of the available drugs are designed to act on specific targets by altering the activity of involved transporters and genes. Taking into account the high antiviral and antiproliferative activity against tumor cell lines displayed by some marine natural products reported in the literature, sixty five marine organisms were selected: 51 sponges (Porifera), 13 ascidians (Chordata), and 1 gorgonian (Cnidaria), collected from Yucatan Peninsula, Mexico, to evaluate their antiviral activity against human adenovirus type 5 (HAdV5) and their anticancer properties against five human tumor cell lines, namely human lung carcinoma (A549), human skin melanoma (A2058), hepatocyte carcinoma (HepG2), breast adenocarcinoma (MCF7), and pancreas carcinoma (MiaPaca-2). Eleven extracts displayed anti-HAdV activity being the organic extracts of Dysidea sp., Agelas citrina, Chondrilla sp., Spongia tubulifera, and Monanchora arbuscula the five most active ones. On the other hand, 24 extracts showed antiproliferative activity against at least one tumor cell line, being the extracts of the ascidian Eudistoma amanitum and the sponge Haliclona (Rhizoniera) curacaoensis the most active ones. This work constitutes the first wide antiviral and antiproliferative screening report of extracts from the marine sponges, ascidians, and a gorgonian collected from the Yucatan Peninsula, Mexico. |
| first_indexed | 2024-04-12T04:35:48Z |
| format | Article |
| id | doaj.art-74a7191ac0ef4203b8ac4b5f2ba289ba |
| institution | Directory Open Access Journal |
| issn | 2296-7745 |
| language | English |
| last_indexed | 2024-04-12T04:35:48Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Marine Science |
| spelling | doaj.art-74a7191ac0ef4203b8ac4b5f2ba289ba2022-12-22T03:47:49ZengFrontiers Media S.A.Frontiers in Marine Science2296-77452020-08-01710.3389/fmars.2020.00607555215Antiviral and Antiproliferative Potential of Marine Organisms From the Yucatan Peninsula, MexicoDawrin Pech-Puch0Judith Berastegui-Cabrera1Mar Pérez-Povedano2Harold Villegas-Hernández3Sergio Guillén-Hernández4Bastien Cautain5Fernando Reyes6Jerónimo Pachón7Patricia Gómez8Jaime Rodríguez9Carlos Jiménez10Javier Sánchez-Céspedes11Centro de Investigacións Científicas Avanzadas (CICA) e Departamento de Química, Facultade de Ciencias, AE CICA-INIBIC, Universidade da Coruña, A Coruña, SpainUnit of Infectious Diseases, Microbiology and Preventive Medicine, Virgen del Rocío University Hospital/Institute of Biomedicine of Seville (IBiS), Seville, SpainCentro de Investigacións Científicas Avanzadas (CICA) e Departamento de Química, Facultade de Ciencias, AE CICA-INIBIC, Universidade da Coruña, A Coruña, SpainDepartamento de Biología Marina, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, MexicoDepartamento de Biología Marina, Campus de Ciencias Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, MexicoFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Granada, SpainFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Granada, SpainUnit of Infectious Diseases, Microbiology and Preventive Medicine, Virgen del Rocío University Hospital/Institute of Biomedicine of Seville (IBiS), Seville, SpainUnidad Académica de Ecología y Biodiversidad Acuática, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Mexico City, MexicoCentro de Investigacións Científicas Avanzadas (CICA) e Departamento de Química, Facultade de Ciencias, AE CICA-INIBIC, Universidade da Coruña, A Coruña, SpainCentro de Investigacións Científicas Avanzadas (CICA) e Departamento de Química, Facultade de Ciencias, AE CICA-INIBIC, Universidade da Coruña, A Coruña, SpainUnit of Infectious Diseases, Microbiology and Preventive Medicine, Virgen del Rocío University Hospital/Institute of Biomedicine of Seville (IBiS), Seville, SpainViral infections are one of the main human health problems in recent decades and the cancer remains one of the most lethal diseases worldwide. The development of new antiviral drugs for the treatment of human adenovirus (HAdV) infections continues to be a challenging goal for medicinal chemistry. There is no specific antiviral drug approved to treat infections caused by HAdV so far and the off-label treatments currently available show great variability in their effectiveness. In relation to cancer, most of the available drugs are designed to act on specific targets by altering the activity of involved transporters and genes. Taking into account the high antiviral and antiproliferative activity against tumor cell lines displayed by some marine natural products reported in the literature, sixty five marine organisms were selected: 51 sponges (Porifera), 13 ascidians (Chordata), and 1 gorgonian (Cnidaria), collected from Yucatan Peninsula, Mexico, to evaluate their antiviral activity against human adenovirus type 5 (HAdV5) and their anticancer properties against five human tumor cell lines, namely human lung carcinoma (A549), human skin melanoma (A2058), hepatocyte carcinoma (HepG2), breast adenocarcinoma (MCF7), and pancreas carcinoma (MiaPaca-2). Eleven extracts displayed anti-HAdV activity being the organic extracts of Dysidea sp., Agelas citrina, Chondrilla sp., Spongia tubulifera, and Monanchora arbuscula the five most active ones. On the other hand, 24 extracts showed antiproliferative activity against at least one tumor cell line, being the extracts of the ascidian Eudistoma amanitum and the sponge Haliclona (Rhizoniera) curacaoensis the most active ones. This work constitutes the first wide antiviral and antiproliferative screening report of extracts from the marine sponges, ascidians, and a gorgonian collected from the Yucatan Peninsula, Mexico.https://www.frontiersin.org/article/10.3389/fmars.2020.00607/fullantiviralantiproliferativeYucatan Peninsulamarine organisms extractsspongesascidians |
| spellingShingle | Dawrin Pech-Puch Judith Berastegui-Cabrera Mar Pérez-Povedano Harold Villegas-Hernández Sergio Guillén-Hernández Bastien Cautain Fernando Reyes Jerónimo Pachón Patricia Gómez Jaime Rodríguez Carlos Jiménez Javier Sánchez-Céspedes Antiviral and Antiproliferative Potential of Marine Organisms From the Yucatan Peninsula, Mexico Frontiers in Marine Science antiviral antiproliferative Yucatan Peninsula marine organisms extracts sponges ascidians |
| title | Antiviral and Antiproliferative Potential of Marine Organisms From the Yucatan Peninsula, Mexico |
| title_full | Antiviral and Antiproliferative Potential of Marine Organisms From the Yucatan Peninsula, Mexico |
| title_fullStr | Antiviral and Antiproliferative Potential of Marine Organisms From the Yucatan Peninsula, Mexico |
| title_full_unstemmed | Antiviral and Antiproliferative Potential of Marine Organisms From the Yucatan Peninsula, Mexico |
| title_short | Antiviral and Antiproliferative Potential of Marine Organisms From the Yucatan Peninsula, Mexico |
| title_sort | antiviral and antiproliferative potential of marine organisms from the yucatan peninsula mexico |
| topic | antiviral antiproliferative Yucatan Peninsula marine organisms extracts sponges ascidians |
| url | https://www.frontiersin.org/article/10.3389/fmars.2020.00607/full |
| work_keys_str_mv | AT dawrinpechpuch antiviralandantiproliferativepotentialofmarineorganismsfromtheyucatanpeninsulamexico AT judithberasteguicabrera antiviralandantiproliferativepotentialofmarineorganismsfromtheyucatanpeninsulamexico AT marperezpovedano antiviralandantiproliferativepotentialofmarineorganismsfromtheyucatanpeninsulamexico AT haroldvillegashernandez antiviralandantiproliferativepotentialofmarineorganismsfromtheyucatanpeninsulamexico AT sergioguillenhernandez antiviralandantiproliferativepotentialofmarineorganismsfromtheyucatanpeninsulamexico AT bastiencautain antiviralandantiproliferativepotentialofmarineorganismsfromtheyucatanpeninsulamexico AT fernandoreyes antiviralandantiproliferativepotentialofmarineorganismsfromtheyucatanpeninsulamexico AT jeronimopachon antiviralandantiproliferativepotentialofmarineorganismsfromtheyucatanpeninsulamexico AT patriciagomez antiviralandantiproliferativepotentialofmarineorganismsfromtheyucatanpeninsulamexico AT jaimerodriguez antiviralandantiproliferativepotentialofmarineorganismsfromtheyucatanpeninsulamexico AT carlosjimenez antiviralandantiproliferativepotentialofmarineorganismsfromtheyucatanpeninsulamexico AT javiersanchezcespedes antiviralandantiproliferativepotentialofmarineorganismsfromtheyucatanpeninsulamexico |