Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniae
Abstract Pharmaceuticals occur in the environment due to their excessive consumption and the inefficiency of treatment plants to degrade, inactivate or remove them. Diazepam (DZP) stands out as the most consumed benzodiazepine, and induces sedative effects and reduces anxiety. Considering its poten...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Ciências
2020-04-01
|
| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100713&tlng=en |
| _version_ | 1798014496681230336 |
|---|---|
| author | ALLYSON Q. DA SILVA JEAMYLLE NILIN SUSANA LOUREIRO LETICIA V. COSTA-LOTUFO |
| author_facet | ALLYSON Q. DA SILVA JEAMYLLE NILIN SUSANA LOUREIRO LETICIA V. COSTA-LOTUFO |
| author_sort | ALLYSON Q. DA SILVA |
| collection | DOAJ |
| description | Abstract Pharmaceuticals occur in the environment due to their excessive consumption and the inefficiency of treatment plants to degrade, inactivate or remove them. Diazepam (DZP) stands out as the most consumed benzodiazepine, and induces sedative effects and reduces anxiety. Considering its potential appearance in several environmental compartments, the aim of the present study was to determine the effects of DZP under acute and chronic exposures on the mysid Mysidopsis juniae. Mortality was assessed using an acute toxicity test and a LC50 of 3.7 ± 0.5 mg·L-1was derived. The mass and length of the mysids was recorded in the chronic exposure to test for sublethal effects, and concentrations of 0.25 and 0.5 mg·L-1 of DZP affected mysids length and dry weight, respectively. Although effect-inducing concentrations used in this study are above environmentally relevant levels, the present study adds value to the limited available data for DZP toxicity to marine organisms, and we have shown that M. juniae is the most sensitive marine crustacean species tested thus far. |
| first_indexed | 2024-04-11T15:19:22Z |
| format | Article |
| id | doaj.art-74a907847ba348548171ac9ad51c9957 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-11T15:19:22Z |
| publishDate | 2020-04-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-74a907847ba348548171ac9ad51c99572022-12-22T04:16:25ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902020-04-0192110.1590/0001-3765202020180595Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniaeALLYSON Q. DA SILVAhttps://orcid.org/0000-0002-7756-1426JEAMYLLE NILINhttps://orcid.org/0000-0002-1636-4541SUSANA LOUREIROhttps://orcid.org/0000-0002-5393-9623LETICIA V. COSTA-LOTUFOhttps://orcid.org/0000-0003-1861-5153Abstract Pharmaceuticals occur in the environment due to their excessive consumption and the inefficiency of treatment plants to degrade, inactivate or remove them. Diazepam (DZP) stands out as the most consumed benzodiazepine, and induces sedative effects and reduces anxiety. Considering its potential appearance in several environmental compartments, the aim of the present study was to determine the effects of DZP under acute and chronic exposures on the mysid Mysidopsis juniae. Mortality was assessed using an acute toxicity test and a LC50 of 3.7 ± 0.5 mg·L-1was derived. The mass and length of the mysids was recorded in the chronic exposure to test for sublethal effects, and concentrations of 0.25 and 0.5 mg·L-1 of DZP affected mysids length and dry weight, respectively. Although effect-inducing concentrations used in this study are above environmentally relevant levels, the present study adds value to the limited available data for DZP toxicity to marine organisms, and we have shown that M. juniae is the most sensitive marine crustacean species tested thus far.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100713&tlng=enemerging contaminantsmysidssublethal effectspharmaceuticals |
| spellingShingle | ALLYSON Q. DA SILVA JEAMYLLE NILIN SUSANA LOUREIRO LETICIA V. COSTA-LOTUFO Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniae Anais da Academia Brasileira de Ciências emerging contaminants mysids sublethal effects pharmaceuticals |
| title | Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniae |
| title_full | Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniae |
| title_fullStr | Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniae |
| title_full_unstemmed | Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniae |
| title_short | Acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean Mysidopsis juniae |
| title_sort | acute and chronic toxicity of the benzodiazepine diazepam to the tropical crustacean mysidopsis juniae |
| topic | emerging contaminants mysids sublethal effects pharmaceuticals |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100713&tlng=en |
| work_keys_str_mv | AT allysonqdasilva acuteandchronictoxicityofthebenzodiazepinediazepamtothetropicalcrustaceanmysidopsisjuniae AT jeamyllenilin acuteandchronictoxicityofthebenzodiazepinediazepamtothetropicalcrustaceanmysidopsisjuniae AT susanaloureiro acuteandchronictoxicityofthebenzodiazepinediazepamtothetropicalcrustaceanmysidopsisjuniae AT leticiavcostalotufo acuteandchronictoxicityofthebenzodiazepinediazepamtothetropicalcrustaceanmysidopsisjuniae |