The role of absolute neutrophil count, mean platelet volume and lymphocyte monocyte ratio as a simple blood markers In the diagnosis and prediction of treatment response In spontaneous bacterial peritonitis In Egyptian cirrhotic patients.
Background and aim: A potentially fatal side effect of decompensated liver cirrhosis is ascites. One potentially dangerous consequence in cirrhotic individuals with ascites is spontaneous bacterial peritonitis (SBP). Diagnostic paracentesis is a method used to diagnose SBP, although it is an invasi...
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| Format: | Article |
| Language: | English |
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Zagazig University, Faculty of Medicine
2024-02-01
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| Series: | Microbes and Infectious Diseases |
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| Online Access: | https://mid.journals.ekb.eg/article_327564_36abc4efb072cff4fa158aec01148d09.pdf |
| _version_ | 1797317259023089664 |
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| author | Shimaa Mansour Kariman Elkasrawy Fatma Elgebaly |
| author_facet | Shimaa Mansour Kariman Elkasrawy Fatma Elgebaly |
| author_sort | Shimaa Mansour |
| collection | DOAJ |
| description | Background and aim: A potentially fatal side effect of decompensated liver cirrhosis is ascites. One potentially dangerous consequence in cirrhotic individuals with ascites is spontaneous bacterial peritonitis (SBP). Diagnostic paracentesis is a method used to diagnose SBP, although it is an invasive procedure. Numerous noninvasive markers were investigated in SBP diagnosis. Thus, this study aimed to assess the clinical utility of the noninvasive markers for the diagnosis and treatment response in patients with SBP, namely the lymphocyte monocyte ratio (LMR), mean platelet volume (MPV), and absolute neutrophil count (ANC). Patients and methods: This study included 162 cirrhotic patients was conducted. They were divided into 2 groups, group I included 101 cirrhotic patients with SBP and group II included 61 cirrhotic patients without SBP. ascitic fluid sampling and complete blood count (CBC) including ANC, LMR and MPV were done. Results: There was a significant difference between the 2 groups as regard ANC and LMR (p<0.05). In SBP group there was a significant difference in ANC, LMR, MPV before and after the standard\antibiotic treatment. Absolute neutrophil count had sensitivity 79.21%, specificity 63.93% However, the LMR had sensitivity 91.09 %, specificity 68.85 % and MPV had sensitivity 83.17%, specificity 62.30%. When ANC, LMR and MPV were combined, the sensitivity was 91.10% and specificity was 91.80%. Conclusion: This study suggests that the ANC, MPV, and LMR may be utilized as noninvasive markers for the diagnosis of SBP and prediction of treatment response, enabling prompt detection of SBP to minimize its consequences. |
| first_indexed | 2024-03-08T03:32:20Z |
| format | Article |
| id | doaj.art-74aae65d561d4b18a6e3f00382880456 |
| institution | Directory Open Access Journal |
| issn | 2682-4132 2682-4140 |
| language | English |
| last_indexed | 2024-03-08T03:32:20Z |
| publishDate | 2024-02-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj.art-74aae65d561d4b18a6e3f003828804562024-02-10T21:57:30ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402024-02-015122022910.21608/mid.2023.246107.1648327564The role of absolute neutrophil count, mean platelet volume and lymphocyte monocyte ratio as a simple blood markers In the diagnosis and prediction of treatment response In spontaneous bacterial peritonitis In Egyptian cirrhotic patients.Shimaa Mansour0Kariman Elkasrawy1Fatma Elgebaly2Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, EgyptDepartment of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, EgyptDepartment of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, EgyptBackground and aim: A potentially fatal side effect of decompensated liver cirrhosis is ascites. One potentially dangerous consequence in cirrhotic individuals with ascites is spontaneous bacterial peritonitis (SBP). Diagnostic paracentesis is a method used to diagnose SBP, although it is an invasive procedure. Numerous noninvasive markers were investigated in SBP diagnosis. Thus, this study aimed to assess the clinical utility of the noninvasive markers for the diagnosis and treatment response in patients with SBP, namely the lymphocyte monocyte ratio (LMR), mean platelet volume (MPV), and absolute neutrophil count (ANC). Patients and methods: This study included 162 cirrhotic patients was conducted. They were divided into 2 groups, group I included 101 cirrhotic patients with SBP and group II included 61 cirrhotic patients without SBP. ascitic fluid sampling and complete blood count (CBC) including ANC, LMR and MPV were done. Results: There was a significant difference between the 2 groups as regard ANC and LMR (p<0.05). In SBP group there was a significant difference in ANC, LMR, MPV before and after the standard\antibiotic treatment. Absolute neutrophil count had sensitivity 79.21%, specificity 63.93% However, the LMR had sensitivity 91.09 %, specificity 68.85 % and MPV had sensitivity 83.17%, specificity 62.30%. When ANC, LMR and MPV were combined, the sensitivity was 91.10% and specificity was 91.80%. Conclusion: This study suggests that the ANC, MPV, and LMR may be utilized as noninvasive markers for the diagnosis of SBP and prediction of treatment response, enabling prompt detection of SBP to minimize its consequences.https://mid.journals.ekb.eg/article_327564_36abc4efb072cff4fa158aec01148d09.pdfspontaneous bacterial peritonitisabsolute neutrophil countmean platelet volumelymphocyte monocyte ratioblood markers |
| spellingShingle | Shimaa Mansour Kariman Elkasrawy Fatma Elgebaly The role of absolute neutrophil count, mean platelet volume and lymphocyte monocyte ratio as a simple blood markers In the diagnosis and prediction of treatment response In spontaneous bacterial peritonitis In Egyptian cirrhotic patients. Microbes and Infectious Diseases spontaneous bacterial peritonitis absolute neutrophil count mean platelet volume lymphocyte monocyte ratio blood markers |
| title | The role of absolute neutrophil count, mean platelet volume and lymphocyte monocyte ratio as a simple blood markers In the diagnosis and prediction of treatment response In spontaneous bacterial peritonitis In Egyptian cirrhotic patients. |
| title_full | The role of absolute neutrophil count, mean platelet volume and lymphocyte monocyte ratio as a simple blood markers In the diagnosis and prediction of treatment response In spontaneous bacterial peritonitis In Egyptian cirrhotic patients. |
| title_fullStr | The role of absolute neutrophil count, mean platelet volume and lymphocyte monocyte ratio as a simple blood markers In the diagnosis and prediction of treatment response In spontaneous bacterial peritonitis In Egyptian cirrhotic patients. |
| title_full_unstemmed | The role of absolute neutrophil count, mean platelet volume and lymphocyte monocyte ratio as a simple blood markers In the diagnosis and prediction of treatment response In spontaneous bacterial peritonitis In Egyptian cirrhotic patients. |
| title_short | The role of absolute neutrophil count, mean platelet volume and lymphocyte monocyte ratio as a simple blood markers In the diagnosis and prediction of treatment response In spontaneous bacterial peritonitis In Egyptian cirrhotic patients. |
| title_sort | role of absolute neutrophil count mean platelet volume and lymphocyte monocyte ratio as a simple blood markers in the diagnosis and prediction of treatment response in spontaneous bacterial peritonitis in egyptian cirrhotic patients |
| topic | spontaneous bacterial peritonitis absolute neutrophil count mean platelet volume lymphocyte monocyte ratio blood markers |
| url | https://mid.journals.ekb.eg/article_327564_36abc4efb072cff4fa158aec01148d09.pdf |
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