Negative prognostic behaviour of PD-L1 expression in tongue and larynx squamous cell carcinoma and its significant predictive power in combination with PD-1 expression on TILs

Negative prognostic behaviour of PD-L1 expression in tongue and larynx squamous cell carcinoma and its significant predictive power in combination with PD-1 expression on TILs

Abstract Background Biomarkers that can predict outcome will improve the efficacy of treatment for HNSCC patients. In this regard, we retrospectively evaluated the prognostic effect of PD1, PD-L1, and CD45RO in tongue and larynx squamous cell carcinomas. Methods FFPE tissue blocks of 63 larynx and 4...

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Bibliographic Details
Main Authors: Simin Ahmadvand, Lotf-Ali Norouzi, Yousef Mohammadi, Akbar Safaei, Bijan Khademi, Maziar Motiee-Langroudi, Abbas Ghaderi
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Immunology
Subjects:
Head and Neck Squamous Cell Carcinoma
Checkpoint Inhibitor Immunotherapy
PD-1
PD-L1
Tumor Infiltrating Lymphocytes
Tumor Microenvironment
Online Access:https://doi.org/10.1186/s12865-024-00597-0

Internet

https://doi.org/10.1186/s12865-024-00597-0

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