Osteopontin, a bridge links osteoarthritis and osteoporosis
Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of articular cartilage, inflammation, and changes in periarticular and subchondral bone of joints. Osteoporosis (OP) is another systemic skeletal disease characterized by low bone mass and bone mineral density (BMD)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1012508/full |
| _version_ | 1811197242880557056 |
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| author | Rui-Jun Bai Yu-Sheng Li Yu-Sheng Li Fang-Jie Zhang Fang-Jie Zhang |
| author_facet | Rui-Jun Bai Yu-Sheng Li Yu-Sheng Li Fang-Jie Zhang Fang-Jie Zhang |
| author_sort | Rui-Jun Bai |
| collection | DOAJ |
| description | Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of articular cartilage, inflammation, and changes in periarticular and subchondral bone of joints. Osteoporosis (OP) is another systemic skeletal disease characterized by low bone mass and bone mineral density (BMD) accompanied by microarchitectural deterioration in bone tissue and increased bone fragility and fracture risk. Both OA and OP are mainly affected on the elderly people. Recent studies have shown that osteopontin (OPN) plays a vital role in bone metabolism and homeostasis. OPN involves these biological activities through participating in the proliferation, migration, differentiation, and adhesion of several bone-related cells, including chondrocytes, synoviocytes, osteoclasts, osteoblasts, and marrow mesenchymal stem cells (MSCs). OPN has been demonstrated to be closely related to the occurrence and development of many bone-related diseases, such as OA and OP. This review summarizes the role of OPN in regulating inflammation activity and bone metabolism in OA and OP. Furthermore, some drugs that targeted OPN to treat OA and OP are also summarized in the review. However, the complex mechanism of OPN in regulating OA and OP is not fully elucidated, which drives us to explore the depth effect of OPN on these two bone diseases. |
| first_indexed | 2024-04-12T01:12:01Z |
| format | Article |
| id | doaj.art-74ac0029b92f4281904950d651b9d4d0 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T01:12:01Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-74ac0029b92f4281904950d651b9d4d02022-12-22T03:54:04ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-10-011310.3389/fendo.2022.10125081012508Osteopontin, a bridge links osteoarthritis and osteoporosisRui-Jun Bai0Yu-Sheng Li1Yu-Sheng Li2Fang-Jie Zhang3Fang-Jie Zhang4Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan, ChinaDepartment of Emergency Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaOsteoarthritis (OA) is the most prevalent joint disease characterized by degradation of articular cartilage, inflammation, and changes in periarticular and subchondral bone of joints. Osteoporosis (OP) is another systemic skeletal disease characterized by low bone mass and bone mineral density (BMD) accompanied by microarchitectural deterioration in bone tissue and increased bone fragility and fracture risk. Both OA and OP are mainly affected on the elderly people. Recent studies have shown that osteopontin (OPN) plays a vital role in bone metabolism and homeostasis. OPN involves these biological activities through participating in the proliferation, migration, differentiation, and adhesion of several bone-related cells, including chondrocytes, synoviocytes, osteoclasts, osteoblasts, and marrow mesenchymal stem cells (MSCs). OPN has been demonstrated to be closely related to the occurrence and development of many bone-related diseases, such as OA and OP. This review summarizes the role of OPN in regulating inflammation activity and bone metabolism in OA and OP. Furthermore, some drugs that targeted OPN to treat OA and OP are also summarized in the review. However, the complex mechanism of OPN in regulating OA and OP is not fully elucidated, which drives us to explore the depth effect of OPN on these two bone diseases.https://www.frontiersin.org/articles/10.3389/fendo.2022.1012508/fullbone metabolisminflammationosteoarthritisosteoporosisosteopontin |
| spellingShingle | Rui-Jun Bai Yu-Sheng Li Yu-Sheng Li Fang-Jie Zhang Fang-Jie Zhang Osteopontin, a bridge links osteoarthritis and osteoporosis Frontiers in Endocrinology bone metabolism inflammation osteoarthritis osteoporosis osteopontin |
| title | Osteopontin, a bridge links osteoarthritis and osteoporosis |
| title_full | Osteopontin, a bridge links osteoarthritis and osteoporosis |
| title_fullStr | Osteopontin, a bridge links osteoarthritis and osteoporosis |
| title_full_unstemmed | Osteopontin, a bridge links osteoarthritis and osteoporosis |
| title_short | Osteopontin, a bridge links osteoarthritis and osteoporosis |
| title_sort | osteopontin a bridge links osteoarthritis and osteoporosis |
| topic | bone metabolism inflammation osteoarthritis osteoporosis osteopontin |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1012508/full |
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