Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander.
BACKGROUND: We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand. METHODS: From September 1, 2003-August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain r...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3066183?pdf=render |
| _version_ | 1818562285778501632 |
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| author | Alicia M Fry Xiaoyan Lu Sonja J Olsen Malinee Chittaganpitch Pongpun Sawatwong Somrak Chantra Henry C Baggett Dean Erdman |
| author_facet | Alicia M Fry Xiaoyan Lu Sonja J Olsen Malinee Chittaganpitch Pongpun Sawatwong Somrak Chantra Henry C Baggett Dean Erdman |
| author_sort | Alicia M Fry |
| collection | DOAJ |
| description | BACKGROUND: We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand. METHODS: From September 1, 2003-August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence. RESULTS: HRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: <1 year: 29%, 1-4 year: 29%, ≥ 65 years: 9%; controls: <1 year: 24%, 1-4 year: 14%, ≥ 65 years: 2.8%). Enrollment adjusted hospitalized HRV detection rates were highest among persons aged <1 year (1038/100,000 persons/year), 1-4 years (457), and ≥ 65 years (71). All three HRV species were identified, HRV-A was the most common species in most age groups including children aged <1 year (61%) and all adult age groups. HRV-C was the most common species in the 1-4 year (51%) and 5-19 year age groups (54%). Compared to controls, hospitalized adults (≥ 19 years) and children were more likely to have HRV detections (odds ratio [OR]: 4.8, 95% confidence interval [CI]: 1.5, 15.8; OR: 2.0, CI: 1.2, 3.3, respectively) and hospitalized children were more likely to have HRV-A (OR 1.7, CI: 0.8, 3.5) or HVR-C (OR 2.7, CI: 1.2, 5.9) detection. CONCLUSIONS: HRV rates were high among hospitalized children and the elderly but asymptomatic children also had substantial HRV detection. HRV (all species), and HRV-A and HRV-C detections were epidemiologically-associated with hospitalized illness. Treatment or prevention modalities effective against HRV could reduce hospitalizations due to HRV in Thailand. |
| first_indexed | 2024-12-14T01:01:42Z |
| format | Article |
| id | doaj.art-74ae89bd257840cf90f57f7607219f92 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T01:01:42Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-74ae89bd257840cf90f57f7607219f922022-12-21T23:23:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0163e1778010.1371/journal.pone.0017780Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander.Alicia M FryXiaoyan LuSonja J OlsenMalinee ChittaganpitchPongpun SawatwongSomrak ChantraHenry C BaggettDean ErdmanBACKGROUND: We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand. METHODS: From September 1, 2003-August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence. RESULTS: HRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: <1 year: 29%, 1-4 year: 29%, ≥ 65 years: 9%; controls: <1 year: 24%, 1-4 year: 14%, ≥ 65 years: 2.8%). Enrollment adjusted hospitalized HRV detection rates were highest among persons aged <1 year (1038/100,000 persons/year), 1-4 years (457), and ≥ 65 years (71). All three HRV species were identified, HRV-A was the most common species in most age groups including children aged <1 year (61%) and all adult age groups. HRV-C was the most common species in the 1-4 year (51%) and 5-19 year age groups (54%). Compared to controls, hospitalized adults (≥ 19 years) and children were more likely to have HRV detections (odds ratio [OR]: 4.8, 95% confidence interval [CI]: 1.5, 15.8; OR: 2.0, CI: 1.2, 3.3, respectively) and hospitalized children were more likely to have HRV-A (OR 1.7, CI: 0.8, 3.5) or HVR-C (OR 2.7, CI: 1.2, 5.9) detection. CONCLUSIONS: HRV rates were high among hospitalized children and the elderly but asymptomatic children also had substantial HRV detection. HRV (all species), and HRV-A and HRV-C detections were epidemiologically-associated with hospitalized illness. Treatment or prevention modalities effective against HRV could reduce hospitalizations due to HRV in Thailand.http://europepmc.org/articles/PMC3066183?pdf=render |
| spellingShingle | Alicia M Fry Xiaoyan Lu Sonja J Olsen Malinee Chittaganpitch Pongpun Sawatwong Somrak Chantra Henry C Baggett Dean Erdman Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander. PLoS ONE |
| title | Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander. |
| title_full | Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander. |
| title_fullStr | Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander. |
| title_full_unstemmed | Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander. |
| title_short | Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander. |
| title_sort | human rhinovirus infections in rural thailand epidemiological evidence for rhinovirus as both pathogen and bystander |
| url | http://europepmc.org/articles/PMC3066183?pdf=render |
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