Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients?
Pentraxin-3 (PTX-3) is the prototype of long pentraxins and is produced by many tissues and organs including vascular endothelial cells in response to pro-inflammatory signals. It is thought to be an independent indicator of disease activity. We analyzed the correlation of PTX-3 with other markers o...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2012-09-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X1201000305 |
| _version_ | 1831807939691675648 |
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| author | M. Gursu S. Ozturk Z. Aydin S. Karadag Y. Doventas M. Koldas S. Uzun A. Sumnu R. Kazancioglu |
| author_facet | M. Gursu S. Ozturk Z. Aydin S. Karadag Y. Doventas M. Koldas S. Uzun A. Sumnu R. Kazancioglu |
| author_sort | M. Gursu |
| collection | DOAJ |
| description | Pentraxin-3 (PTX-3) is the prototype of long pentraxins and is produced by many tissues and organs including vascular endothelial cells in response to pro-inflammatory signals. It is thought to be an independent indicator of disease activity. We analyzed the correlation of PTX-3 with other markers of inflammation in peritoneal dialysis (PD) patients. Non-diabetic patients on chronic PD program who meet the dialysis adequacy criteria and who had no active infectious/inflammatory disease were included. Demographic and clinical parameters were recorded as well as hsCRP, fibrinogen, interleukin-6 (IL-6) and PTX-3 levels; and the correlation between them were studied. Twenty-five patients (mean age: 45.7±12.5 years; female/male ratio: 16/9) were included. Mean PTX-3 level was 2.16±2.76ng/ml. PTX-3 was found to be correlated positively with only IL-6 among inflammatory markers (r=0.827; p<0.001) but not with hsCRP. With linear regression model, IL-6 was the only independent determinant of PTX-3 levels. PTX-3 may be a more valuable marker of inflammation than CRP in patients on PD. |
| first_indexed | 2024-12-22T20:14:06Z |
| format | Article |
| id | doaj.art-74aeaaf790c447d5a7984e44698ec482 |
| institution | Directory Open Access Journal |
| issn | 1721-727X |
| language | English |
| last_indexed | 2024-12-22T20:14:06Z |
| publishDate | 2012-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-74aeaaf790c447d5a7984e44698ec4822022-12-21T18:14:00ZengSAGE PublishingEuropean Journal of Inflammation1721-727X2012-09-011010.1177/1721727X1201000305Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients?M. Gursu0S. Ozturk1Z. Aydin2S. Karadag3Y. Doventas4M. Koldas5S. Uzun6A. Sumnu7R. Kazancioglu8 Haseki Training and Research Hospital, Department of Nephrology, Istanbul, Turkey Haseki Training and Research Hospital, Department of Nephrology, Istanbul, Turkey Haseki Training and Research Hospital, Department of Nephrology, Istanbul, Turkey Haseki Training and Research Hospital, Department of Nephrology, Istanbul, Turkey Haseki Training and Research Hospital, Department of Biochemistry, Istanbul, Turkey Haseki Training and Research Hospital, Department of Biochemistry, Istanbul, Turkey Haseki Training and Research Hospital, Department of Nephrology, Istanbul, Turkey Haseki Training and Research Hospital, Department of Nephrology, Istanbul, Turkey Bezmialem Vakif University, Medical Faculty, Department of Nephrology, Istanbul, TurkeyPentraxin-3 (PTX-3) is the prototype of long pentraxins and is produced by many tissues and organs including vascular endothelial cells in response to pro-inflammatory signals. It is thought to be an independent indicator of disease activity. We analyzed the correlation of PTX-3 with other markers of inflammation in peritoneal dialysis (PD) patients. Non-diabetic patients on chronic PD program who meet the dialysis adequacy criteria and who had no active infectious/inflammatory disease were included. Demographic and clinical parameters were recorded as well as hsCRP, fibrinogen, interleukin-6 (IL-6) and PTX-3 levels; and the correlation between them were studied. Twenty-five patients (mean age: 45.7±12.5 years; female/male ratio: 16/9) were included. Mean PTX-3 level was 2.16±2.76ng/ml. PTX-3 was found to be correlated positively with only IL-6 among inflammatory markers (r=0.827; p<0.001) but not with hsCRP. With linear regression model, IL-6 was the only independent determinant of PTX-3 levels. PTX-3 may be a more valuable marker of inflammation than CRP in patients on PD.https://doi.org/10.1177/1721727X1201000305 |
| spellingShingle | M. Gursu S. Ozturk Z. Aydin S. Karadag Y. Doventas M. Koldas S. Uzun A. Sumnu R. Kazancioglu Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients? European Journal of Inflammation |
| title | Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients? |
| title_full | Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients? |
| title_fullStr | Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients? |
| title_full_unstemmed | Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients? |
| title_short | Is Pentraxin-3 Stronger Than C-Reactive Protein to Determine Inflammation in Peritoneal Dialysis Patients? |
| title_sort | is pentraxin 3 stronger than c reactive protein to determine inflammation in peritoneal dialysis patients |
| url | https://doi.org/10.1177/1721727X1201000305 |
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