Vagus Nerve Stimulation Reduces Neuroinflammation Through Microglia Polarization Regulation to Improve Functional Recovery After Spinal Cord Injury

Vagus Nerve Stimulation Reduces Neuroinflammation Through Microglia Polarization Regulation to Improve Functional Recovery After Spinal Cord Injury

BackgroundSpinal cord injury (SCI) is a devastating disease that lacks effective treatment. Interestingly, recent studies indicated that vagus nerve stimulation (VNS), neuromodulation that is widely used in a variety of central nervous system (CNS) diseases, improved motor function recovery after SC...

Full description

Bibliographic Details
Main Authors:	Hui Chen, Zhou Feng, Lingxia Min, Weiwei Deng, Mingliang Tan, Jian Hong, Qiuwen Gong, Dongyun Zhang, Hongliang Liu, Jingming Hou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-04-01
Series:	Frontiers in Neuroscience
Subjects:	spinal cord injury vagus nerve stimulation microglial polarization neuroinflammation cholinergic anti-inflammatory pathway alpha 7 nicotinic acetylcholine receptor
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2022.813472/full

Similar Items

Mechanisms of vagus nerve stimulation for the treatment of neurodevelopmental disorders: a focus on microglia and neuroinflammation
by: Makenna Gargus, et al.
Published: (2025-01-01)

Targeting the cholinergic anti-inflammatory pathway with vagus nerve stimulation in patients with Covid-19?
by: Bruno Bonaz, et al.
Published: (2020-07-01)

Vagal afferent fibers contribute to the anti-inflammatory reactions by vagus nerve stimulation in concanavalin A model of hepatitis in rats
by: Byung Gon Jo, et al.
Published: (2020-12-01)

Is the post-COVID-19 syndrome a severe impairment of acetylcholine-orchestrated neuromodulation that responds to nicotine administration?
by: Marco Leitzke
Published: (2023-01-01)

Electroacupuncture Ameliorates Acute Pancreatitis: A Role for the Vagus Nerve–Mediated Cholinergic Anti-Inflammatory Pathway
by: Luyao Zhang, et al.
Published: (2021-05-01)

The Cholinergic System Modulates Memory and Hippocampal Plasticity via Its Interactions with Non-Neuronal Cells
by: Sara V. Maurer, et al.
Published: (2017-11-01)

Electric stimulation of the vagus nerve reduced mouse neuroinflammation induced by lipopolysaccharide
by: G. Meneses, et al.
Published: (2016-10-01)

Vagus Nerve Stimulation for Improvement of Vascular Cognitive Impairment
by: E R, et al.
Published: (2024-07-01)

Neuroinflammation in Schizophrenia
by: Feytie Magda Mawey, et al.
Published: (2021-05-01)

Vagus Nerve Stimulation Transiently Mitigates Chemotherapy-Induced Peripheral Neuropathy in Rats
by: Zhang R, et al.
Published: (2020-12-01)

Collateral benefits of studying the vagus nerve in bioelectronic medicine
by: Valentin A. Pavlov
Published: (2019-05-01)

Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications
by: Yi-Ting Fang, et al.
Published: (2023-07-01)

Vagus nerve stimulation enhances remyelination and decreases innate neuroinflammation in lysolecithin-induced demyelination
by: Helen Bachmann, et al.
Published: (2024-05-01)

The Vagus Nerve in the Neuro-Immune Axis: Implications in the Pathology of the Gastrointestinal Tract
by: Bruno Bonaz, et al.
Published: (2017-11-01)

Characterization of nAChRs in Nematostella vectensis supports neuronal and non-neuronal roles in the cnidarian–bilaterian common ancestor
by: Dylan Z. Faltine-Gonzalez, et al.
Published: (2019-11-01)

Could vagus nerve stimulation target hippocampal hyperactivity to improve cognition in schizophrenia?
by: Jason eSmucny, et al.
Published: (2015-03-01)

Transcutaneous Vagus Nerve Stimulation Regulates the Cholinergic Anti-inflammatory Pathway to Counteract 1, 2-Dimethylhydrazine Induced Colon Carcinogenesis in Albino wistar Rats
by: Jitendra K. Rawat, et al.
Published: (2019-05-01)

Therapeutic Potential of Vagus Nerve Stimulation for Inflammatory Bowel Diseases
by: Bruno Bonaz, et al.
Published: (2021-03-01)

Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm
by: Huan Yang, et al.
Published: (2022-05-01)

Neuroinflammation Modulation via α7 Nicotinic Acetylcholine Receptor and Its Chaperone, RIC-3
by: Tehila Mizrachi, et al.
Published: (2021-10-01)

Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine
by: Kristin Andrud, et al.
Published: (2019-10-01)

Organization of the Subdiaphragmatic Vagus Nerve and Its Connection with the Celiac Plexus and the Ovaries in the Female Rat
by: María E. Rivera-Castro, et al.
Published: (2023-07-01)

Enhanced BBB penetration and microglia-targeting nanomodulator for the two-pronged modulation of chronically activated microglia-mediated neuroinflammation in Alzheimer's disease
by: Ya Wei, et al.
Published: (2025-02-01)

Research Progress in Ultrasonic Regulation of Cholinergic Anti-inflammatory Pathwa
by: Wuqi Zhou, MD, Yishu Song, MD, Rui Wang, MD, Qiaofeng Jin, MD, Mingxing Xie, PhD, Li Zhang, PhD
Published: (2022-12-01)

Safety and tolerability of adjunct non-invasive vagus nerve stimulation in people with parkinson’s: a study protocol
by: Hilmar P. Sigurdsson, et al.
Published: (2023-02-01)

Neutrophil Extracellular Traps Exacerbate Secondary Injury via Promoting Neuroinflammation and Blood–Spinal Cord Barrier Disruption in Spinal Cord Injury
by: Zhou Feng, et al.
Published: (2021-08-01)

Pathophysiology of nAChRs: Limbic circuits and related disorders
by: Yann S. Mineur, et al.
Published: (2023-05-01)

Evolution in Neuromodulation—The Differential Roles of Acetylcholine in Higher Order Association vs. Primary Visual Cortices
by: Veronica C. Galvin, et al.
Published: (2018-08-01)

Evaluation of the cholinomimetic actions of trimethylsulfonium, a compound present in the midgut gland of the sea hare Aplysia brasiliana (Gastropoda, Opisthobranchia)
by: C.M. Kerchove, et al.
Published: (2002-04-01)

Editorial: Dysfunctional microglia in neurological disorders
by: Anup Bhusal, et al.
Published: (2023-01-01)

DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation
by: Long-Qing Zhang, et al.
Published: (2022-06-01)

Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer’s Disease
by: Kazuyuki Takata, et al.
Published: (2022-04-01)

Laparotomy-Induced Peripheral Inflammation Activates NR2B Receptors on the Brain Mast Cells and Results in Neuroinflammation in a Vagus Nerve-Dependent Manner
by: Jing Yang, et al.
Published: (2022-02-01)

Microglia Mediated Neuroinflammation in Parkinson’s Disease
by: Sevim Isik, et al.
Published: (2023-03-01)

Rapid Effects of Vagus Nerve Stimulation on Sensory Processing Through Activation of Neuromodulatory Systems
by: Charles Rodenkirch, et al.
Published: (2022-07-01)

Taming microglia: the promise of engineered microglia in treating neurological diseases
by: Echo Yongqi Luo, et al.
Published: (2024-01-01)

Neurorehabilitation with vagus nerve stimulation: a systematic review
by: Radha Korupolu, et al.
Published: (2024-05-01)

Is the vagus nerve our neural connectome?
by: V Reggie Edgerton, et al.
Published: (2018-03-01)

Frequency-specific modulation of oscillatory activity in the rat auditory cortex by vagus nerve stimulation
by: Shinichi Kumagai, et al.
Published: (2023-09-01)

Alteration of Cholinergic Anti‐Inflammatory Pathway in Rat With Ischemic Cardiomyopathy–Modified Electrophysiological Function of Heart
by: Shu‐Jie Wu, et al.
Published: (2017-09-01)