<i>CYP26A1</i> Links WNT and Retinoic Acid Signaling: A Target to Differentiate ALDH+ Stem Cells in <i>APC</i>-Mutant CRC
<i>APC</i> mutation is the main driving mechanism of CRC development and leads to constitutively activated WNT signaling, overpopulation of ALDH+ stem cells (SCs), and incomplete differentiation. We previously reported that retinoic acid (RA) receptors are selectively expressed in ALDH+...
Main Authors: | Caroline O. B. Facey, Victoria O. Hunsu, Chi Zhang, Brian Osmond, Lynn M. Opdenaker, Bruce M. Boman |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2024-01-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/16/2/264 |
Similar Items
-
Ashkenazi Jewish and Other White <i>APC</i> I1307K Carriers Are at Higher Risk for Multiple Cancers
by: Esther Forkosh, et al.
Published: (2022-11-01) -
Clinicopathological Characteristics and Mutational Landscape of <i>APC</i>, <i>HOXB13,</i> and <i>KRAS</i> among Rwandan Patients with Colorectal Cancer
by: Felix Manirakiza, et al.
Published: (2023-05-01) -
<i>APC</i> and <i>TP53</i> Mutations Predict Cetuximab Sensitivity across Consensus Molecular Subtypes
by: Ramya Thota, et al.
Published: (2021-10-01) -
Pathogenic <i>APC</i> Variants in Latvian Familial Adenomatous Polyposis Patients
by: Zanda Daneberga, et al.
Published: (2019-09-01) -
<i>APC</i> Splicing Mutations Leading to In-Frame Exon 12 or Exon 13 Skipping Are Rare Events in FAP Pathogenesis and Define the Clinical Outcome
by: Vittoria Disciglio, et al.
Published: (2021-02-01)