Lymphocyte-to-C-Reactive Protein (LCR) Ratio Is Not Accurate to Predict Severity and Mortality in Patients with COVID-19 Admitted to the ED
Health care systems worldwide have been battling the ongoing COVID-19 pandemic. Since the beginning of the COVID-19 pandemic, Lymphocytes and CRP have been reported as markers of interest. We chose to investigate the prognostic value of the LCR ratio as a marker of severity and mortality in COVID-19...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/6/5996 |
| _version_ | 1797611171570778112 |
|---|---|
| author | Laure Abensur Vuillaume François Lefebvre Axel Benhamed Amandine Schnee Mathieu Hoffmann Fernanda Godoy Falcao Nathan Haber Jonathan Sabah Charles-Eric Lavoignet Pierrick Le Borgne |
| author_facet | Laure Abensur Vuillaume François Lefebvre Axel Benhamed Amandine Schnee Mathieu Hoffmann Fernanda Godoy Falcao Nathan Haber Jonathan Sabah Charles-Eric Lavoignet Pierrick Le Borgne |
| author_sort | Laure Abensur Vuillaume |
| collection | DOAJ |
| description | Health care systems worldwide have been battling the ongoing COVID-19 pandemic. Since the beginning of the COVID-19 pandemic, Lymphocytes and CRP have been reported as markers of interest. We chose to investigate the prognostic value of the LCR ratio as a marker of severity and mortality in COVID-19 infection. Between 1 March and 30 April 2020, we conducted a multicenter, retrospective cohort study of patients with moderate and severe coronavirus disease 19 (COVID-19), all of whom were hospitalized after being admitted to the Emergency Department (ED). We conducted our study in six major hospitals of northeast France, one of the outbreak’s epicenters in Europe. A total of 1035 patients with COVID-19 were included in our study. Around three-quarters of them (76.2%) presented a moderate form of the disease, while the remaining quarter (23.8%) presented a severe form requiring admission to the ICU. At ED admission, the median LCR was significantly lower in the group presenting severe disease compared to that with moderate disease (versus 6.24 (3.24–12) versus 12.63 ((6.05–31.67)), <i>p</i> < 0.001). However, LCR was neither associated with disease severity (OR: 0.99, CI 95% (0.99–1)), <i>p</i> = 0.476) nor mortality (OR: 0.99, CI 95% (0.99–1)). In the ED, LCR, although modest, with a threshold of 12.63, was a predictive marker for severe forms of COVID-19. |
| first_indexed | 2024-03-11T06:24:04Z |
| format | Article |
| id | doaj.art-74b230c371b042dea66040e224995a35 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T06:24:04Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-74b230c371b042dea66040e224995a352023-11-17T11:41:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01246599610.3390/ijms24065996Lymphocyte-to-C-Reactive Protein (LCR) Ratio Is Not Accurate to Predict Severity and Mortality in Patients with COVID-19 Admitted to the EDLaure Abensur Vuillaume0François Lefebvre1Axel Benhamed2Amandine Schnee3Mathieu Hoffmann4Fernanda Godoy Falcao5Nathan Haber6Jonathan Sabah7Charles-Eric Lavoignet8Pierrick Le Borgne9Emergency Department, CHR Metz-Thionville, 57000 Metz, FranceDepartment of Public Health, University Hospital of Strasbourg, 67000 Strasbourg, FranceService SAMU-Urgences, Centre Hospitalier Universitaire Édouard Herriot, Hospices Civils de Lyon, 69000 Lyon, FranceEmergency Department, CHR Metz-Thionville, 57000 Metz, FranceEmergency Department, CHR Metz-Thionville, 57000 Metz, FranceEmergency Department, CHR Metz-Thionville, 57000 Metz, FranceEmergency Department, CHR Metz-Thionville, 57000 Metz, FranceDepartment of Gynecologic Surgery, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, FranceEmergency Department, Hôpital Nord Franche Comté, 90400 Belfort, FranceEmergency Department, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, FranceHealth care systems worldwide have been battling the ongoing COVID-19 pandemic. Since the beginning of the COVID-19 pandemic, Lymphocytes and CRP have been reported as markers of interest. We chose to investigate the prognostic value of the LCR ratio as a marker of severity and mortality in COVID-19 infection. Between 1 March and 30 April 2020, we conducted a multicenter, retrospective cohort study of patients with moderate and severe coronavirus disease 19 (COVID-19), all of whom were hospitalized after being admitted to the Emergency Department (ED). We conducted our study in six major hospitals of northeast France, one of the outbreak’s epicenters in Europe. A total of 1035 patients with COVID-19 were included in our study. Around three-quarters of them (76.2%) presented a moderate form of the disease, while the remaining quarter (23.8%) presented a severe form requiring admission to the ICU. At ED admission, the median LCR was significantly lower in the group presenting severe disease compared to that with moderate disease (versus 6.24 (3.24–12) versus 12.63 ((6.05–31.67)), <i>p</i> < 0.001). However, LCR was neither associated with disease severity (OR: 0.99, CI 95% (0.99–1)), <i>p</i> = 0.476) nor mortality (OR: 0.99, CI 95% (0.99–1)). In the ED, LCR, although modest, with a threshold of 12.63, was a predictive marker for severe forms of COVID-19.https://www.mdpi.com/1422-0067/24/6/5996lymphocytesC reactive proteinLCRCOVID-19severitymortality |
| spellingShingle | Laure Abensur Vuillaume François Lefebvre Axel Benhamed Amandine Schnee Mathieu Hoffmann Fernanda Godoy Falcao Nathan Haber Jonathan Sabah Charles-Eric Lavoignet Pierrick Le Borgne Lymphocyte-to-C-Reactive Protein (LCR) Ratio Is Not Accurate to Predict Severity and Mortality in Patients with COVID-19 Admitted to the ED International Journal of Molecular Sciences lymphocytes C reactive protein LCR COVID-19 severity mortality |
| title | Lymphocyte-to-C-Reactive Protein (LCR) Ratio Is Not Accurate to Predict Severity and Mortality in Patients with COVID-19 Admitted to the ED |
| title_full | Lymphocyte-to-C-Reactive Protein (LCR) Ratio Is Not Accurate to Predict Severity and Mortality in Patients with COVID-19 Admitted to the ED |
| title_fullStr | Lymphocyte-to-C-Reactive Protein (LCR) Ratio Is Not Accurate to Predict Severity and Mortality in Patients with COVID-19 Admitted to the ED |
| title_full_unstemmed | Lymphocyte-to-C-Reactive Protein (LCR) Ratio Is Not Accurate to Predict Severity and Mortality in Patients with COVID-19 Admitted to the ED |
| title_short | Lymphocyte-to-C-Reactive Protein (LCR) Ratio Is Not Accurate to Predict Severity and Mortality in Patients with COVID-19 Admitted to the ED |
| title_sort | lymphocyte to c reactive protein lcr ratio is not accurate to predict severity and mortality in patients with covid 19 admitted to the ed |
| topic | lymphocytes C reactive protein LCR COVID-19 severity mortality |
| url | https://www.mdpi.com/1422-0067/24/6/5996 |
| work_keys_str_mv | AT laureabensurvuillaume lymphocytetocreactiveproteinlcrratioisnotaccuratetopredictseverityandmortalityinpatientswithcovid19admittedtotheed AT francoislefebvre lymphocytetocreactiveproteinlcrratioisnotaccuratetopredictseverityandmortalityinpatientswithcovid19admittedtotheed AT axelbenhamed lymphocytetocreactiveproteinlcrratioisnotaccuratetopredictseverityandmortalityinpatientswithcovid19admittedtotheed AT amandineschnee lymphocytetocreactiveproteinlcrratioisnotaccuratetopredictseverityandmortalityinpatientswithcovid19admittedtotheed AT mathieuhoffmann lymphocytetocreactiveproteinlcrratioisnotaccuratetopredictseverityandmortalityinpatientswithcovid19admittedtotheed AT fernandagodoyfalcao lymphocytetocreactiveproteinlcrratioisnotaccuratetopredictseverityandmortalityinpatientswithcovid19admittedtotheed AT nathanhaber lymphocytetocreactiveproteinlcrratioisnotaccuratetopredictseverityandmortalityinpatientswithcovid19admittedtotheed AT jonathansabah lymphocytetocreactiveproteinlcrratioisnotaccuratetopredictseverityandmortalityinpatientswithcovid19admittedtotheed AT charlesericlavoignet lymphocytetocreactiveproteinlcrratioisnotaccuratetopredictseverityandmortalityinpatientswithcovid19admittedtotheed AT pierrickleborgne lymphocytetocreactiveproteinlcrratioisnotaccuratetopredictseverityandmortalityinpatientswithcovid19admittedtotheed |