RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment
Countering Bone Loss in Space A chemical element naturally found for instance in seafood or grains, could counter bone loss from long-term spaceflight. Alain Guignandon and colleagues from the Université de Lyon à St-Etienne in France exposed multipotent embryonic fibroblasts to microgravity conditi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-01-01
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| Series: | npj Microgravity |
| Online Access: | https://doi.org/10.1038/s41526-016-0004-6 |
| _version_ | 1797428739370385408 |
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| author | Fiona Louis Wafa Bouleftour Aline Rattner Marie-Thérèse Linossier Laurence Vico Alain Guignandon |
| author_facet | Fiona Louis Wafa Bouleftour Aline Rattner Marie-Thérèse Linossier Laurence Vico Alain Guignandon |
| author_sort | Fiona Louis |
| collection | DOAJ |
| description | Countering Bone Loss in Space A chemical element naturally found for instance in seafood or grains, could counter bone loss from long-term spaceflight. Alain Guignandon and colleagues from the Université de Lyon à St-Etienne in France exposed multipotent embryonic fibroblasts to microgravity conditions similar to those found in space. They found the balance shifted in these stem cells from differentiating to bone-forming cells (osteoblasts) to differentiating to fatty-tissue forming cells (adipocytes). When the cells were treated with strontium, the shift toward osteoblastogenesis was regained. Strontium achieves this by sustaining the activity of two proteins that play a role in bone development but are suppressed in space. Strontium’s effect on the proteins could happen via release of vascular endothelial growth factor, which, under normal gravity conditions, plays a role in committing the cell to differentiation into osteoblasts rather than adipoyctes. |
| first_indexed | 2024-03-09T09:03:14Z |
| format | Article |
| id | doaj.art-74b4487b9a43410ab4bb7e9d1adb01a1 |
| institution | Directory Open Access Journal |
| issn | 2373-8065 |
| language | English |
| last_indexed | 2024-03-09T09:03:14Z |
| publishDate | 2017-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Microgravity |
| spelling | doaj.art-74b4487b9a43410ab4bb7e9d1adb01a12023-12-02T11:07:13ZengNature Portfolionpj Microgravity2373-80652017-01-013111210.1038/s41526-016-0004-6RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitmentFiona Louis0Wafa Bouleftour1Aline Rattner2Marie-Thérèse Linossier3Laurence Vico4Alain Guignandon5INSERM, U1059, SAINBIOSEINSERM, U1059, SAINBIOSEINSERM, U1059, SAINBIOSEINSERM, U1059, SAINBIOSEINSERM, U1059, SAINBIOSEINSERM, U1059, SAINBIOSECountering Bone Loss in Space A chemical element naturally found for instance in seafood or grains, could counter bone loss from long-term spaceflight. Alain Guignandon and colleagues from the Université de Lyon à St-Etienne in France exposed multipotent embryonic fibroblasts to microgravity conditions similar to those found in space. They found the balance shifted in these stem cells from differentiating to bone-forming cells (osteoblasts) to differentiating to fatty-tissue forming cells (adipocytes). When the cells were treated with strontium, the shift toward osteoblastogenesis was regained. Strontium achieves this by sustaining the activity of two proteins that play a role in bone development but are suppressed in space. Strontium’s effect on the proteins could happen via release of vascular endothelial growth factor, which, under normal gravity conditions, plays a role in committing the cell to differentiation into osteoblasts rather than adipoyctes.https://doi.org/10.1038/s41526-016-0004-6 |
| spellingShingle | Fiona Louis Wafa Bouleftour Aline Rattner Marie-Thérèse Linossier Laurence Vico Alain Guignandon RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment npj Microgravity |
| title | RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment |
| title_full | RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment |
| title_fullStr | RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment |
| title_full_unstemmed | RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment |
| title_short | RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment |
| title_sort | rhogtpase stimulation is associated with strontium chloride treatment to counter simulated microgravity induced changes in multipotent cell commitment |
| url | https://doi.org/10.1038/s41526-016-0004-6 |
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