Incidence of renal cell carcinoma after solid organ transplantation: a systematic review and meta-analysis
Abstract Background The incidence rate of malignant tumors after solid organ transplantation is higher than the normal population. The aim of our study is to identify the risk of renal cell carcinoma (RCC) after liver, kidney, heart and lung transplantation, respectively, and suggest that transplant...
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| Format: | Article |
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BMC
2024-01-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-023-01389-1 |
| _version_ | 1827388141362741248 |
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| author | Chang Xu Hefeng Geng Yannan Li Fang Sun Huiwei Sun Yingshi Zhang Qingchun Zhao |
| author_facet | Chang Xu Hefeng Geng Yannan Li Fang Sun Huiwei Sun Yingshi Zhang Qingchun Zhao |
| author_sort | Chang Xu |
| collection | DOAJ |
| description | Abstract Background The incidence rate of malignant tumors after solid organ transplantation is higher than the normal population. The aim of our study is to identify the risk of renal cell carcinoma (RCC) after liver, kidney, heart and lung transplantation, respectively, and suggest that transplant patients can be screened early for tumors to avoid risk. Methods PubMed, Embase and the Cochrane Library from their inception until August 16,2023. Retrospective and cohort studies which focus on the statistical data of standardized incidence ratios (SIRs) of RCC after solid organ transplantation (SOT) more than one year have been included and extracted. The study was registered with PROSPERO, CRD4202022343633. Results Sixteen original studies have been included for meta-analysis. Liver transplantation could increase the risk of RCC (SIR = 0.73, 95%CI: 0.53 to 0.93) with no heterogeneity(P = 0.594, I 2 = 0.0%). And kidney transplantation could increase the risk of RCC(8.54, 6.68 to 10.40; 0.000,90.0%). Besides, heart and lung transplantation also could increase the risk of RCC(SIR = 0.73, 95%CI: 0.53 to 0.93; SIR = 1.61, 95%CI:0.50 to 2.71). Moreover, significance could also be found in most subgroups, especially the European group and retrospective study group. What’s more, after removing studies which have a greater impact on the overall outcome in RCC rate after kidney transplantation, heterogeneity did not solve and significant different was also observed in the European group (7.15, 5.49 to 8.81; 0.000, 78.6%). Conclusion Liver, kidney, heart and lung transplantation patients have an increased risk of processing RCC compared to the general population and most subgroups, especially in geographic location of European subgroup, which suggested that patients should be screened frequently after transplantation. |
| first_indexed | 2024-03-08T16:13:23Z |
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| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-03-08T16:13:23Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
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| series | BMC Urology |
| spelling | doaj.art-74b484b7730e4a7989113448aff635b72024-01-07T12:48:49ZengBMCBMC Urology1471-24902024-01-012411910.1186/s12894-023-01389-1Incidence of renal cell carcinoma after solid organ transplantation: a systematic review and meta-analysisChang Xu0Hefeng Geng1Yannan Li2Fang Sun3Huiwei Sun4Yingshi Zhang5Qingchun Zhao6Teaching Hospital of Shenyang Pharmaceutical University, General Hospital of Northern Theater CommandTeaching Hospital of Shenyang Pharmaceutical University, General Hospital of Northern Theater CommandDepartment of Clinical Pharmacy, Shenyang Pharmaceutical UniversityInstitute of Infectious Disease, Department of Infectious Disease, The Fifth Medical Center of Chinese PLA General HospitalInstitute of Infectious Disease, Department of Infectious Disease, The Fifth Medical Center of Chinese PLA General HospitalTeaching Hospital of Shenyang Pharmaceutical University, General Hospital of Northern Theater CommandTeaching Hospital of Shenyang Pharmaceutical University, General Hospital of Northern Theater CommandAbstract Background The incidence rate of malignant tumors after solid organ transplantation is higher than the normal population. The aim of our study is to identify the risk of renal cell carcinoma (RCC) after liver, kidney, heart and lung transplantation, respectively, and suggest that transplant patients can be screened early for tumors to avoid risk. Methods PubMed, Embase and the Cochrane Library from their inception until August 16,2023. Retrospective and cohort studies which focus on the statistical data of standardized incidence ratios (SIRs) of RCC after solid organ transplantation (SOT) more than one year have been included and extracted. The study was registered with PROSPERO, CRD4202022343633. Results Sixteen original studies have been included for meta-analysis. Liver transplantation could increase the risk of RCC (SIR = 0.73, 95%CI: 0.53 to 0.93) with no heterogeneity(P = 0.594, I 2 = 0.0%). And kidney transplantation could increase the risk of RCC(8.54, 6.68 to 10.40; 0.000,90.0%). Besides, heart and lung transplantation also could increase the risk of RCC(SIR = 0.73, 95%CI: 0.53 to 0.93; SIR = 1.61, 95%CI:0.50 to 2.71). Moreover, significance could also be found in most subgroups, especially the European group and retrospective study group. What’s more, after removing studies which have a greater impact on the overall outcome in RCC rate after kidney transplantation, heterogeneity did not solve and significant different was also observed in the European group (7.15, 5.49 to 8.81; 0.000, 78.6%). Conclusion Liver, kidney, heart and lung transplantation patients have an increased risk of processing RCC compared to the general population and most subgroups, especially in geographic location of European subgroup, which suggested that patients should be screened frequently after transplantation.https://doi.org/10.1186/s12894-023-01389-1Incidence of renal cell carcinomaSolid organ transplantationMalignant incidenceSystematic reviewMeta-analysis |
| spellingShingle | Chang Xu Hefeng Geng Yannan Li Fang Sun Huiwei Sun Yingshi Zhang Qingchun Zhao Incidence of renal cell carcinoma after solid organ transplantation: a systematic review and meta-analysis BMC Urology Incidence of renal cell carcinoma Solid organ transplantation Malignant incidence Systematic review Meta-analysis |
| title | Incidence of renal cell carcinoma after solid organ transplantation: a systematic review and meta-analysis |
| title_full | Incidence of renal cell carcinoma after solid organ transplantation: a systematic review and meta-analysis |
| title_fullStr | Incidence of renal cell carcinoma after solid organ transplantation: a systematic review and meta-analysis |
| title_full_unstemmed | Incidence of renal cell carcinoma after solid organ transplantation: a systematic review and meta-analysis |
| title_short | Incidence of renal cell carcinoma after solid organ transplantation: a systematic review and meta-analysis |
| title_sort | incidence of renal cell carcinoma after solid organ transplantation a systematic review and meta analysis |
| topic | Incidence of renal cell carcinoma Solid organ transplantation Malignant incidence Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12894-023-01389-1 |
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