HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells
Abstract Choroidal melanoma (CM) is the most common type of diagnosed uveal melanoma (UM), which is prone to metastasis and exhibits a poor prognosis. The molecular mechanisms underlying CM progression need further elucidation to research effective therapeutic strategies. Histone deacetylase 7 (HDAC...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-01-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-022-05522-0 |
| _version_ | 1828056648260780032 |
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| author | Yimeng Zhang Peng Ding Yuanyong Wang Changjian Shao Kai Guo Hanyi Yang Yingtong Feng Jiayi Ning Minghong Pan Ping Wang Xiaolong Yan Zhiqiang Ma Jing Han |
| author_facet | Yimeng Zhang Peng Ding Yuanyong Wang Changjian Shao Kai Guo Hanyi Yang Yingtong Feng Jiayi Ning Minghong Pan Ping Wang Xiaolong Yan Zhiqiang Ma Jing Han |
| author_sort | Yimeng Zhang |
| collection | DOAJ |
| description | Abstract Choroidal melanoma (CM) is the most common type of diagnosed uveal melanoma (UM), which is prone to metastasis and exhibits a poor prognosis. The molecular mechanisms underlying CM progression need further elucidation to research effective therapeutic strategies. Histone deacetylase 7 (HDAC7) is very important in regulating cancer progression, but the significance and effect of HDAC7 on CM progression are unclear. In the present study, we found that HDAC7 is overexpressed in CM tissues versus normal tissues. We built HDAC7 overexpressing CM cell lines to study the functions of HDAC7 in CM progression and verified that upregulation of HDAC7 promoted the proliferation and metastasis of CM cells, while pharmacological inhibition of HDAC7 suppressed both the proliferation and metastasis of CM cells. Furthermore, we found that the aforementioned cancer-promoting effect of HDAC7 was mediated by c-Myc. Targeted inhibition of c-Myc inhibited CM progression by interfering with the HDAC7/c-Myc signaling pathway. Our study highlighted the function of targeting the HDAC7/c-Myc signaling pathway to intervene in the pathological process of CM, which provides potential therapeutic strategies for CM treatment. |
| first_indexed | 2024-04-10T20:58:54Z |
| format | Article |
| id | doaj.art-74b4c71c09c640c3b8a1164ca6e04b8c |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-10T20:58:54Z |
| publishDate | 2023-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-74b4c71c09c640c3b8a1164ca6e04b8c2023-01-22T12:26:42ZengNature Publishing GroupCell Death and Disease2041-48892023-01-0114111110.1038/s41419-022-05522-0HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cellsYimeng Zhang0Peng Ding1Yuanyong Wang2Changjian Shao3Kai Guo4Hanyi Yang5Yingtong Feng6Jiayi Ning7Minghong Pan8Ping Wang9Xiaolong Yan10Zhiqiang Ma11Jing Han12Department of Ophthalmology, Tangdu Hospital, The Air Force Medical UniversityDepartment of Thoracic Surgery, Tangdu Hospital, The Air Force Medical UniversityDepartment of Thoracic Surgery, Tangdu Hospital, The Air Force Medical UniversityDepartment of Thoracic Surgery, Tangdu Hospital, The Air Force Medical UniversityDepartment of Thoracic Surgery, Shaanxi Provincial People’s Hospital, The Third Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Ophthalmology, Tangdu Hospital, The Air Force Medical UniversityDepartment of Cardiothoracic Surgery, The Affiliated Huaihai Hospital of Xuzhou Medical University/The 71th Group Army Hospital of PLADepartment of Ophthalmology, Tangdu Hospital, The Air Force Medical UniversityDepartment of Thoracic Surgery, Tangdu Hospital, The Air Force Medical UniversityDepartment of Ophthalmology, Tangdu Hospital, The Air Force Medical UniversityDepartment of Thoracic Surgery, Tangdu Hospital, The Air Force Medical UniversityDepartment of Medical Oncology, Senior Department of Oncology, Chinese PLA General Hospital, The Fifth Medical CenterDepartment of Ophthalmology, Tangdu Hospital, The Air Force Medical UniversityAbstract Choroidal melanoma (CM) is the most common type of diagnosed uveal melanoma (UM), which is prone to metastasis and exhibits a poor prognosis. The molecular mechanisms underlying CM progression need further elucidation to research effective therapeutic strategies. Histone deacetylase 7 (HDAC7) is very important in regulating cancer progression, but the significance and effect of HDAC7 on CM progression are unclear. In the present study, we found that HDAC7 is overexpressed in CM tissues versus normal tissues. We built HDAC7 overexpressing CM cell lines to study the functions of HDAC7 in CM progression and verified that upregulation of HDAC7 promoted the proliferation and metastasis of CM cells, while pharmacological inhibition of HDAC7 suppressed both the proliferation and metastasis of CM cells. Furthermore, we found that the aforementioned cancer-promoting effect of HDAC7 was mediated by c-Myc. Targeted inhibition of c-Myc inhibited CM progression by interfering with the HDAC7/c-Myc signaling pathway. Our study highlighted the function of targeting the HDAC7/c-Myc signaling pathway to intervene in the pathological process of CM, which provides potential therapeutic strategies for CM treatment.https://doi.org/10.1038/s41419-022-05522-0 |
| spellingShingle | Yimeng Zhang Peng Ding Yuanyong Wang Changjian Shao Kai Guo Hanyi Yang Yingtong Feng Jiayi Ning Minghong Pan Ping Wang Xiaolong Yan Zhiqiang Ma Jing Han HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells Cell Death and Disease |
| title | HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells |
| title_full | HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells |
| title_fullStr | HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells |
| title_full_unstemmed | HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells |
| title_short | HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells |
| title_sort | hdac7 c myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells |
| url | https://doi.org/10.1038/s41419-022-05522-0 |
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