Cytokine secretion in stem cells of cattle infected with bovine leukaemia virus
Bovine leukaemia virus (BLV) is a Deltaretrovirus responsible for enzootic bovine leukosis, the most common neoplastic disease of cattle. It deregulates the immune system, favouring secondary infections and changes in the blood and lymphatic tissues. Blood homeostasis depends on functional haematopo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Sciendo
2024-03-01
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| Series: | Journal of Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/jvetres-2024-0012 |
| _version_ | 1797246597568921600 |
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| author | Szczotka Maria Kuźmak Jacek |
| author_facet | Szczotka Maria Kuźmak Jacek |
| author_sort | Szczotka Maria |
| collection | DOAJ |
| description | Bovine leukaemia virus (BLV) is a Deltaretrovirus responsible for enzootic bovine leukosis, the most common neoplastic disease of cattle. It deregulates the immune system, favouring secondary infections and changes in the blood and lymphatic tissues. Blood homeostasis depends on functional haematopoietic stem cells (HSCs). Bone marrow is populated by these cells, which express CD34+ and CD35+ surface antigens and produce and release cytokines involved in the maintenance of haematopoiesis. The aim of the study was determination of the profile of cytokine production by CD34+ stem cells of cattle naturally infected with BLV. |
| first_indexed | 2024-04-24T19:45:20Z |
| format | Article |
| id | doaj.art-74b56b236cbd4fa5a1b3d5139de260e0 |
| institution | Directory Open Access Journal |
| issn | 2450-8608 |
| language | English |
| last_indexed | 2024-04-24T19:45:20Z |
| publishDate | 2024-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Veterinary Research |
| spelling | doaj.art-74b56b236cbd4fa5a1b3d5139de260e02024-03-25T07:30:32ZengSciendoJournal of Veterinary Research2450-86082024-03-01681193310.2478/jvetres-2024-0012Cytokine secretion in stem cells of cattle infected with bovine leukaemia virusSzczotka Maria0Kuźmak Jacek1Department of Biochemistry, National Veterinary Research Institute, 24–100Puławy, PolandDepartment of Biochemistry, National Veterinary Research Institute, 24–100Puławy, PolandBovine leukaemia virus (BLV) is a Deltaretrovirus responsible for enzootic bovine leukosis, the most common neoplastic disease of cattle. It deregulates the immune system, favouring secondary infections and changes in the blood and lymphatic tissues. Blood homeostasis depends on functional haematopoietic stem cells (HSCs). Bone marrow is populated by these cells, which express CD34+ and CD35+ surface antigens and produce and release cytokines involved in the maintenance of haematopoiesis. The aim of the study was determination of the profile of cytokine production by CD34+ stem cells of cattle naturally infected with BLV.https://doi.org/10.2478/jvetres-2024-0012bovine leukaemia virus (blv)stem cells cd34+cytokinesflow cytometry |
| spellingShingle | Szczotka Maria Kuźmak Jacek Cytokine secretion in stem cells of cattle infected with bovine leukaemia virus Journal of Veterinary Research bovine leukaemia virus (blv) stem cells cd34+ cytokines flow cytometry |
| title | Cytokine secretion in stem cells of cattle infected with bovine leukaemia virus |
| title_full | Cytokine secretion in stem cells of cattle infected with bovine leukaemia virus |
| title_fullStr | Cytokine secretion in stem cells of cattle infected with bovine leukaemia virus |
| title_full_unstemmed | Cytokine secretion in stem cells of cattle infected with bovine leukaemia virus |
| title_short | Cytokine secretion in stem cells of cattle infected with bovine leukaemia virus |
| title_sort | cytokine secretion in stem cells of cattle infected with bovine leukaemia virus |
| topic | bovine leukaemia virus (blv) stem cells cd34+ cytokines flow cytometry |
| url | https://doi.org/10.2478/jvetres-2024-0012 |
| work_keys_str_mv | AT szczotkamaria cytokinesecretioninstemcellsofcattleinfectedwithbovineleukaemiavirus AT kuzmakjacek cytokinesecretioninstemcellsofcattleinfectedwithbovineleukaemiavirus |