The modifying role of pregnancy on ophthalmological and neuro-ophthalmological diseases
The female visual system experiences a series of physiological modifications during pregnancy, and these changes have profound implications on many general ophthalmological and neuro-ophthalmological disorders, exacerbating some conditions while alleviating others. Patients with open-angle glaucoma...
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| Format: | Article |
| Language: | English |
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University of Ottawa
2017-12-01
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| Series: | University of Ottawa Journal of Medicine |
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| Online Access: | https://uottawa.scholarsportal.info/ottawa/index.php/uojm-jmuo/article/view/2102 |
| _version_ | 1811316951439376384 |
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| author | Henry Liu Yiu-chia Chang Xiang Ji |
| author_facet | Henry Liu Yiu-chia Chang Xiang Ji |
| author_sort | Henry Liu |
| collection | DOAJ |
| description | The female visual system experiences a series of physiological modifications during pregnancy, and these changes have profound implications on many general ophthalmological and neuro-ophthalmological disorders, exacerbating some conditions while alleviating others. Patients with open-angle glaucoma experience improved disease states, with accompanying normal visual fields. Uveitis and MS-induced optic neuritis exhibit decreased rates of occurrence. Non-proliferative diabetic retinopathy initially worsens with gestation, eventually improving in the postpartum state with only 5% of cases progressing into the proliferative stage. As for idiopathic intracranial hypertension, existing symptoms worsen during pregnancy. Therapeutic interventions such as immunosuppressants, anti-neoplastic drugs, and steroids administered prophylactically during fetal development may lead to potential teratogenic outcomes manifesting in devastating birth defects and should be administered with caution.
Résumé
Le système visuel féminin subit une série de modifications physiologiques pendant la grossesse, et ces changements ont des implications profondes sur de nombreux troubles ophtalmologiques et neuro-ophtalmologiques généraux, exacerbant certaines conditions tout en soulageant d’autres. Les patients atteints de glaucome à angle ouvert ont une amélioration des états pathologiques, accompagnés de champs visuels normaux. L’uvéite et la névrite optique induite par la SEP présentent des taux d’occurrence réduits. La rétinopathie diabétique non proliférative s’aggrave au début avec la gestation, s’améliorant finalement dans l’état postpartum avec seulement 5% des cas progressant dans le stade prolifératif. En ce qui concerne l’hypertension intracrânienne idiopathique, les symptômes existants s’aggravent pendant la grossesse. Les interventions thérapeutiques comme les immunosuppresseurs, les médicaments antinéoplasiques et les stéroïdes administrés de façon prophylactique pendant le développement du fœtus peuvent entraîner des effets tératogènes potentiels se manifestant par des malformations congénitales dévastatrices et doivent être administrés avec prudence. |
| first_indexed | 2024-04-13T11:59:11Z |
| format | Article |
| id | doaj.art-74b5d96d855e489d801ca735d0b469fe |
| institution | Directory Open Access Journal |
| issn | 2292-650X 2292-6518 |
| language | English |
| last_indexed | 2024-04-13T11:59:11Z |
| publishDate | 2017-12-01 |
| publisher | University of Ottawa |
| record_format | Article |
| series | University of Ottawa Journal of Medicine |
| spelling | doaj.art-74b5d96d855e489d801ca735d0b469fe2022-12-22T02:47:50ZengUniversity of OttawaUniversity of Ottawa Journal of Medicine2292-650X2292-65182017-12-017210.18192/uojm.v7i2.2102The modifying role of pregnancy on ophthalmological and neuro-ophthalmological diseasesHenry Liu0Yiu-chia Chang1Xiang Ji2Faculty of Medicine, University of OttawaFaculty of Medicine, University of OttawaInstitute of Medical Science, University of TorontoThe female visual system experiences a series of physiological modifications during pregnancy, and these changes have profound implications on many general ophthalmological and neuro-ophthalmological disorders, exacerbating some conditions while alleviating others. Patients with open-angle glaucoma experience improved disease states, with accompanying normal visual fields. Uveitis and MS-induced optic neuritis exhibit decreased rates of occurrence. Non-proliferative diabetic retinopathy initially worsens with gestation, eventually improving in the postpartum state with only 5% of cases progressing into the proliferative stage. As for idiopathic intracranial hypertension, existing symptoms worsen during pregnancy. Therapeutic interventions such as immunosuppressants, anti-neoplastic drugs, and steroids administered prophylactically during fetal development may lead to potential teratogenic outcomes manifesting in devastating birth defects and should be administered with caution. Résumé Le système visuel féminin subit une série de modifications physiologiques pendant la grossesse, et ces changements ont des implications profondes sur de nombreux troubles ophtalmologiques et neuro-ophtalmologiques généraux, exacerbant certaines conditions tout en soulageant d’autres. Les patients atteints de glaucome à angle ouvert ont une amélioration des états pathologiques, accompagnés de champs visuels normaux. L’uvéite et la névrite optique induite par la SEP présentent des taux d’occurrence réduits. La rétinopathie diabétique non proliférative s’aggrave au début avec la gestation, s’améliorant finalement dans l’état postpartum avec seulement 5% des cas progressant dans le stade prolifératif. En ce qui concerne l’hypertension intracrânienne idiopathique, les symptômes existants s’aggravent pendant la grossesse. Les interventions thérapeutiques comme les immunosuppresseurs, les médicaments antinéoplasiques et les stéroïdes administrés de façon prophylactique pendant le développement du fœtus peuvent entraîner des effets tératogènes potentiels se manifestant par des malformations congénitales dévastatrices et doivent être administrés avec prudence.https://uottawa.scholarsportal.info/ottawa/index.php/uojm-jmuo/article/view/2102PregnancyOphthalmologyTeratogenicityNeuro-Ophthalmology |
| spellingShingle | Henry Liu Yiu-chia Chang Xiang Ji The modifying role of pregnancy on ophthalmological and neuro-ophthalmological diseases University of Ottawa Journal of Medicine Pregnancy Ophthalmology Teratogenicity Neuro-Ophthalmology |
| title | The modifying role of pregnancy on ophthalmological and neuro-ophthalmological diseases |
| title_full | The modifying role of pregnancy on ophthalmological and neuro-ophthalmological diseases |
| title_fullStr | The modifying role of pregnancy on ophthalmological and neuro-ophthalmological diseases |
| title_full_unstemmed | The modifying role of pregnancy on ophthalmological and neuro-ophthalmological diseases |
| title_short | The modifying role of pregnancy on ophthalmological and neuro-ophthalmological diseases |
| title_sort | modifying role of pregnancy on ophthalmological and neuro ophthalmological diseases |
| topic | Pregnancy Ophthalmology Teratogenicity Neuro-Ophthalmology |
| url | https://uottawa.scholarsportal.info/ottawa/index.php/uojm-jmuo/article/view/2102 |
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