DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models

DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models

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Down syndrome (DS) is caused by the trisomy of human chromosome 21 (HSA21). A major challenge in DS research is to identify the HSA21 genes that cause specific symptoms. Down syndrome cell adhesion molecule (DSCAM) is encoded by a HSA21 gene. Previous studies have shown that the protein level of the...

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Bibliographic Details
Main Authors: Hao Liu, René N. Caballero-Florán, Ty Hergenreder, Tao Yang, Jacob M. Hull, Geng Pan, Ruonan Li, Macy W. Veling, Lori L. Isom, Kenneth Y. Kwan, Z. Josh Huang, Peter G. Fuerst, Paul M. Jenkins, Bing Ye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-04-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10118173/?tool=EBI

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