Brain glucose metabolism and gray matter volume in retired professional soccer players: a cross-sectional [18F]FDG-PET/MRI study
Background Professional soccer athletes are exposed to repetitive head impacts and are at risk of developing chronic traumatic encephalopathy. Objective To evaluate regional brain glucose metabolism (rBGM) and gray matter (GM) volume in retired soccer players (RSPs). Methods Ma...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2023-05-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1768666 |
| _version_ | 1797814558096621568 |
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| author | Mateus Rozalem Aranha Artur Martins Coutinho Camila de Godoi Carneiro Bruno Fraccini Pastorello Adalberto Studart-Neto Carla Cristina Guariglia Miriam Harumi Tsunemi Everton Luis Santos Moreira Jéssica Natuline Ianof Renato Anghinah Ricardo Nitrini Giovanni Guido Cerri Juan Fortea Carlos Alberto Buchpiguel Claudia Costa Leite |
| author_facet | Mateus Rozalem Aranha Artur Martins Coutinho Camila de Godoi Carneiro Bruno Fraccini Pastorello Adalberto Studart-Neto Carla Cristina Guariglia Miriam Harumi Tsunemi Everton Luis Santos Moreira Jéssica Natuline Ianof Renato Anghinah Ricardo Nitrini Giovanni Guido Cerri Juan Fortea Carlos Alberto Buchpiguel Claudia Costa Leite |
| author_sort | Mateus Rozalem Aranha |
| collection | DOAJ |
| description | Background Professional soccer athletes are exposed to repetitive head impacts and are at risk of developing chronic traumatic encephalopathy.
Objective To evaluate regional brain glucose metabolism (rBGM) and gray matter (GM) volume in retired soccer players (RSPs).
Methods Male RSPs and age and sex-matched controls prospectively enrolled between 2017 and 2019 underwent neurological and neuropsychological evaluations, brain MRI and [18F]FDG-PET in a 3.0-Tesla PET/MRI scanner. Visual analysis was performed by a blinded neuroradiologist and a blinded nuclear physician. Regional brain glucose metabolism and GM volume were assessed using SPM8 software. Groups were compared using appropriate statistical tests available at SPM8 and R.
Results Nineteen RSPs (median [IQR]: 62 [50–64.5] years old) and 20 controls (60 [48–73] years old) were included. Retired soccer players performed worse on mini-mental state examination, digit span, clock drawing, phonemic and semantic verbal fluency tests, and had reduced rBGM in the left temporal pole (pFDR = 0.008) and the anterior left middle temporal gyrus (pFDR = 0.043). Semantic verbal fluency correlated with rBGM in the right hippocampus, left temporal pole, and posterior left middle temporal gyrus (p ≤ 0.042). Gray matter volume reduction was observed in similar anatomic regions but was less extensive and did not survive correction for multiple comparisons (pFDR ≥ 0.085). Individual [18F]FDG-PET visual analysis revealed seven RSPs with overt hypometabolism in the medial and lateral temporal lobes, frontal lobes, and temporoparietal regions. Retired soccer players had a higher prevalence of septum pellucidum abnormalities on MRI.
Conclusion Retired soccer players had reduced rBGM and GM volume in the temporal lobes and septum pellucidum abnormalities, findings possibly related to repetitive head impacts. |
| first_indexed | 2024-03-13T08:09:25Z |
| format | Article |
| id | doaj.art-74b87e1260154967b9b1bc00f62868f3 |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-03-13T08:09:25Z |
| publishDate | 2023-05-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-74b87e1260154967b9b1bc00f62868f32023-05-31T22:50:56ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42272023-05-01810543344310.1055/s-0043-1768666Brain glucose metabolism and gray matter volume in retired professional soccer players: a cross-sectional [18F]FDG-PET/MRI studyMateus Rozalem Aranha0Artur Martins Coutinho1Camila de Godoi Carneiro2Bruno Fraccini Pastorello3Adalberto Studart-Neto4Carla Cristina Guariglia5Miriam Harumi Tsunemi6Everton Luis Santos Moreira7Jéssica Natuline Ianof8Renato Anghinah9Ricardo Nitrini10Giovanni Guido Cerri11Juan Fortea12Carlos Alberto Buchpiguel13Claudia Costa Leite14Universidade de São Paulo, Faculdade de Medicina, Instituto de Radiologia, São Paulo SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Centro de Medicina Nuclear, São Paulo SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Centro de Medicina Nuclear, São Paulo SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Instituto de Radiologia, São Paulo SP, Brazil.Universidade de São Paulo, Departamento de Neurologia, Faculdade de Medicina, São Paulo SP, Brazil.Universidade de São Paulo, Departamento de Neurologia, Faculdade de Medicina, São Paulo SP, Brazil.Universidade Estadual Paulista, Departamento de Bioestatística, Instituto de Biociências, Botucatu SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Instituto de Radiologia, São Paulo SP, Brazil.Universidade de São Paulo, Departamento de Neurologia, Faculdade de Medicina, São Paulo SP, Brazil.Universidade de São Paulo, Departamento de Neurologia, Faculdade de Medicina, São Paulo SP, Brazil.Universidade de São Paulo, Departamento de Neurologia, Faculdade de Medicina, São Paulo SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Instituto de Radiologia, São Paulo SP, Brazil.Universidad Autónoma de Barcelona, Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Facultad de Medicina, Barcelona, Spain.Universidade de São Paulo, Faculdade de Medicina, Centro de Medicina Nuclear, São Paulo SP, Brazil.Universidade de São Paulo, Faculdade de Medicina, Instituto de Radiologia, São Paulo SP, Brazil.Background Professional soccer athletes are exposed to repetitive head impacts and are at risk of developing chronic traumatic encephalopathy. Objective To evaluate regional brain glucose metabolism (rBGM) and gray matter (GM) volume in retired soccer players (RSPs). Methods Male RSPs and age and sex-matched controls prospectively enrolled between 2017 and 2019 underwent neurological and neuropsychological evaluations, brain MRI and [18F]FDG-PET in a 3.0-Tesla PET/MRI scanner. Visual analysis was performed by a blinded neuroradiologist and a blinded nuclear physician. Regional brain glucose metabolism and GM volume were assessed using SPM8 software. Groups were compared using appropriate statistical tests available at SPM8 and R. Results Nineteen RSPs (median [IQR]: 62 [50–64.5] years old) and 20 controls (60 [48–73] years old) were included. Retired soccer players performed worse on mini-mental state examination, digit span, clock drawing, phonemic and semantic verbal fluency tests, and had reduced rBGM in the left temporal pole (pFDR = 0.008) and the anterior left middle temporal gyrus (pFDR = 0.043). Semantic verbal fluency correlated with rBGM in the right hippocampus, left temporal pole, and posterior left middle temporal gyrus (p ≤ 0.042). Gray matter volume reduction was observed in similar anatomic regions but was less extensive and did not survive correction for multiple comparisons (pFDR ≥ 0.085). Individual [18F]FDG-PET visual analysis revealed seven RSPs with overt hypometabolism in the medial and lateral temporal lobes, frontal lobes, and temporoparietal regions. Retired soccer players had a higher prevalence of septum pellucidum abnormalities on MRI. Conclusion Retired soccer players had reduced rBGM and GM volume in the temporal lobes and septum pellucidum abnormalities, findings possibly related to repetitive head impacts.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1768666soccerbrain injuries, traumaticchronic traumatic encephalopathypositron-emission tomographymagnetic resonance imaging |
| spellingShingle | Mateus Rozalem Aranha Artur Martins Coutinho Camila de Godoi Carneiro Bruno Fraccini Pastorello Adalberto Studart-Neto Carla Cristina Guariglia Miriam Harumi Tsunemi Everton Luis Santos Moreira Jéssica Natuline Ianof Renato Anghinah Ricardo Nitrini Giovanni Guido Cerri Juan Fortea Carlos Alberto Buchpiguel Claudia Costa Leite Brain glucose metabolism and gray matter volume in retired professional soccer players: a cross-sectional [18F]FDG-PET/MRI study Arquivos de Neuro-Psiquiatria soccer brain injuries, traumatic chronic traumatic encephalopathy positron-emission tomography magnetic resonance imaging |
| title | Brain glucose metabolism and gray matter volume in retired professional soccer players: a cross-sectional [18F]FDG-PET/MRI study |
| title_full | Brain glucose metabolism and gray matter volume in retired professional soccer players: a cross-sectional [18F]FDG-PET/MRI study |
| title_fullStr | Brain glucose metabolism and gray matter volume in retired professional soccer players: a cross-sectional [18F]FDG-PET/MRI study |
| title_full_unstemmed | Brain glucose metabolism and gray matter volume in retired professional soccer players: a cross-sectional [18F]FDG-PET/MRI study |
| title_short | Brain glucose metabolism and gray matter volume in retired professional soccer players: a cross-sectional [18F]FDG-PET/MRI study |
| title_sort | brain glucose metabolism and gray matter volume in retired professional soccer players a cross sectional 18f fdg pet mri study |
| topic | soccer brain injuries, traumatic chronic traumatic encephalopathy positron-emission tomography magnetic resonance imaging |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1768666 |
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