Effectiveness of Probiotics in the Prophylaxis of Necrotizing Enterocolitis in Preterm Neonates: A Systematic Review and Meta-analysis
Objective: To elucidate the benefits of using probiotics in the prevention of necrotizing enterocolitis (NEC) and its complications in preterm newborns. Method: This was a systematic review of randomized controlled trials, which included studies retrieved from three databases (MEDLINE, Embase, and L...
| Auteurs principaux: | , , , , , |
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| Format: | Article |
| Langue: | English |
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Elsevier
2013-01-01
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| Collection: | Jornal de Pediatria |
| Accès en ligne: | http://www.sciencedirect.com/science/article/pii/S0021755713000053 |
| _version_ | 1828149595393228800 |
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| author | Wanderley Marques Bernardo Felipe Toyama Aires Renata Mota Carneiro Fernando Pereira de Sá Vera Esteves Vagnozzi Rullo Dennis Alexander Burns |
| author_facet | Wanderley Marques Bernardo Felipe Toyama Aires Renata Mota Carneiro Fernando Pereira de Sá Vera Esteves Vagnozzi Rullo Dennis Alexander Burns |
| author_sort | Wanderley Marques Bernardo |
| collection | DOAJ |
| description | Objective: To elucidate the benefits of using probiotics in the prevention of necrotizing enterocolitis (NEC) and its complications in preterm newborns. Method: This was a systematic review of randomized controlled trials, which included studies retrieved from three databases (MEDLINE, Embase, and LILACS), using a combination of the terms (necrotizing enterocolitis) AND (probiotics). Results: 11 randomized trials were included, totaling 2,887 patients, 1,431 in the probiotic group and 1,456 in the control group. There was a reduction in the incidence of NEC (NNT = 25), overall death (NNT = 34), and neonatal sepsis (NNT = 34) in the probiotic group compared to the control group. Patients that received probiotic supplementation had lower food reintroduction time (p < 0.001) and hospitalization time (p < 0.001) when compared to those not receiving probiotics. There was no difference in mortality caused by NEC. Conclusion: In premature newborns, the use of probiotics is effective as a prophylaxis for NEC and its complications. Resumo: Objetivo: Elucidar os benefícios do uso de probióticos na prevenção de enterocolite necrosante (ECN) e de suas complicações em recém-nascidos prematuros. Método: Revisão sistemática de ensaios clínicos randomizados, que incluiu pesquisas efetuadas em três bases de dados (MEDLINE, EMBASE e LILACS), utilizando a combinação dos termos (necrotizing enterocolitis) AND (probiotics). Resultados: Foram incluídos 11 ensaios clínicos randomizados, totalizando 2.887 pacien- tes, sendo 1.431 no grupo Probiótico e 1.456 no grupo Controle. Houve redução na incidência de ECN (NNT = 25), de morte global (NNT = 34) e sepse neonatal (NNT = 34) no grupo Probiótico em relação ao grupo Controle. Pacientes alimentados com suple- mentação de probióticos tiveram tempo de reintrodução alimentar (p < 0,001) e de hospitalização (p < 0,001) menor quando comparados aos que não receberam. Não houve diferença na mortalidade causada por ECN. Conclusão: Em recém-nascidos prematuros, o uso de probióticos é eficaz na profilaxia de ECN e de suas complicações. Keywords: Home oxygen therapy, Children, Oxygen, Palavras-chave: Enterocolite necrosante, Probióticos, Prematuros |
| first_indexed | 2024-04-11T21:32:14Z |
| format | Article |
| id | doaj.art-74b95ca5fd8a4a8bb16b51c2511bbf58 |
| institution | Directory Open Access Journal |
| issn | 0021-7557 |
| language | English |
| last_indexed | 2024-04-11T21:32:14Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj.art-74b95ca5fd8a4a8bb16b51c2511bbf582022-12-22T04:01:55ZengElsevierJornal de Pediatria0021-75572013-01-018911824Effectiveness of Probiotics in the Prophylaxis of Necrotizing Enterocolitis in Preterm Neonates: A Systematic Review and Meta-analysisWanderley Marques Bernardo0Felipe Toyama Aires1Renata Mota Carneiro2Fernando Pereira de Sá3Vera Esteves Vagnozzi Rullo4Dennis Alexander Burns5Cientific Coordinator, Projeto Diretrizes, Associação Médica Brasileira and Conselho Federal de Medicina. Professor, Evidence-based Medicine, Faculdade de Ciências Médicas de Santos (UNILUS), Santos, SP, Brazil; Corresponding author.Medical Student, UNILUS, Santos, SP, BrazilMedical Student, UNILUS, Santos, SP, BrazilSpecialist, Sociedade Brasileira de Pediatria. Professor, Clinical Pediatrics, UNILUS, Santos, SP, BrazilPost-doctorate, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil. Professor, Clinical Pediatrics, UNILUS, Santos, SP, BrazilDirector, Sociedade Brasileira de Pediatria. President, Sociedade de Pediatria do Distrito Federal, Brasília, DF, BrazilObjective: To elucidate the benefits of using probiotics in the prevention of necrotizing enterocolitis (NEC) and its complications in preterm newborns. Method: This was a systematic review of randomized controlled trials, which included studies retrieved from three databases (MEDLINE, Embase, and LILACS), using a combination of the terms (necrotizing enterocolitis) AND (probiotics). Results: 11 randomized trials were included, totaling 2,887 patients, 1,431 in the probiotic group and 1,456 in the control group. There was a reduction in the incidence of NEC (NNT = 25), overall death (NNT = 34), and neonatal sepsis (NNT = 34) in the probiotic group compared to the control group. Patients that received probiotic supplementation had lower food reintroduction time (p < 0.001) and hospitalization time (p < 0.001) when compared to those not receiving probiotics. There was no difference in mortality caused by NEC. Conclusion: In premature newborns, the use of probiotics is effective as a prophylaxis for NEC and its complications. Resumo: Objetivo: Elucidar os benefícios do uso de probióticos na prevenção de enterocolite necrosante (ECN) e de suas complicações em recém-nascidos prematuros. Método: Revisão sistemática de ensaios clínicos randomizados, que incluiu pesquisas efetuadas em três bases de dados (MEDLINE, EMBASE e LILACS), utilizando a combinação dos termos (necrotizing enterocolitis) AND (probiotics). Resultados: Foram incluídos 11 ensaios clínicos randomizados, totalizando 2.887 pacien- tes, sendo 1.431 no grupo Probiótico e 1.456 no grupo Controle. Houve redução na incidência de ECN (NNT = 25), de morte global (NNT = 34) e sepse neonatal (NNT = 34) no grupo Probiótico em relação ao grupo Controle. Pacientes alimentados com suple- mentação de probióticos tiveram tempo de reintrodução alimentar (p < 0,001) e de hospitalização (p < 0,001) menor quando comparados aos que não receberam. Não houve diferença na mortalidade causada por ECN. Conclusão: Em recém-nascidos prematuros, o uso de probióticos é eficaz na profilaxia de ECN e de suas complicações. Keywords: Home oxygen therapy, Children, Oxygen, Palavras-chave: Enterocolite necrosante, Probióticos, Prematuroshttp://www.sciencedirect.com/science/article/pii/S0021755713000053 |
| spellingShingle | Wanderley Marques Bernardo Felipe Toyama Aires Renata Mota Carneiro Fernando Pereira de Sá Vera Esteves Vagnozzi Rullo Dennis Alexander Burns Effectiveness of Probiotics in the Prophylaxis of Necrotizing Enterocolitis in Preterm Neonates: A Systematic Review and Meta-analysis Jornal de Pediatria |
| title | Effectiveness of Probiotics in the Prophylaxis of Necrotizing Enterocolitis in Preterm Neonates: A Systematic Review and Meta-analysis |
| title_full | Effectiveness of Probiotics in the Prophylaxis of Necrotizing Enterocolitis in Preterm Neonates: A Systematic Review and Meta-analysis |
| title_fullStr | Effectiveness of Probiotics in the Prophylaxis of Necrotizing Enterocolitis in Preterm Neonates: A Systematic Review and Meta-analysis |
| title_full_unstemmed | Effectiveness of Probiotics in the Prophylaxis of Necrotizing Enterocolitis in Preterm Neonates: A Systematic Review and Meta-analysis |
| title_short | Effectiveness of Probiotics in the Prophylaxis of Necrotizing Enterocolitis in Preterm Neonates: A Systematic Review and Meta-analysis |
| title_sort | effectiveness of probiotics in the prophylaxis of necrotizing enterocolitis in preterm neonates a systematic review and meta analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0021755713000053 |
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