Protective effect of Rubia cordifolia in paclitaxel-induced neuropathic pain in experimental animals
Background: Neuropathic pain is a pain initiated or caused by a primary lesion or dysfunction of the nervous system. Material and Methods: In this study, we evaluated the effect of alcoholic extract of roots and rhizomes of Rubia cordifolia on the development and expression of neuropathic pain induc...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Indian Journal of Pain |
| Subjects: | |
| Online Access: | http://www.indianjpain.org/article.asp?issn=0970-5333;year=2015;volume=29;issue=3;spage=150;epage=154;aulast=Diwane |
| _version_ | 1819208438013493248 |
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| author | Chaitali Diwane Rupali Patil Prashant Vyavahare Rajendra Bhambar |
| author_facet | Chaitali Diwane Rupali Patil Prashant Vyavahare Rajendra Bhambar |
| author_sort | Chaitali Diwane |
| collection | DOAJ |
| description | Background: Neuropathic pain is a pain initiated or caused by a primary lesion or dysfunction of the nervous system. Material and Methods: In this study, we evaluated the effect of alcoholic extract of roots and rhizomes of Rubia cordifolia on the development and expression of neuropathic pain induced by paclitaxel in sciatic nerve ligated rats. A peripheral mononeuropathy was produced in adult Wistar rats by placing loosely constrictive ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated that hyperalgesia, allodynia, and spontaneous pain were produced. Treatment with paclitaxel (2 mg/kg i.p. on 7 th , 10 th , and 21 st day) produced long-lasting (2-3 weeks) heat hyperalgesia and cold allodynia in rats. Conclusion: Co-administration of R. cordifolia extract for 21 days significantly decreased pain indicating its usefulness in neuropathic pain. |
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| format | Article |
| id | doaj.art-74b97b97315a49c3a4378b026cb8c182 |
| institution | Directory Open Access Journal |
| issn | 0970-5333 |
| language | English |
| last_indexed | 2024-12-23T05:39:23Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pain |
| spelling | doaj.art-74b97b97315a49c3a4378b026cb8c1822022-12-21T17:58:14ZengWolters Kluwer Medknow PublicationsIndian Journal of Pain0970-53332015-01-0129315015410.4103/0970-5333.165833Protective effect of Rubia cordifolia in paclitaxel-induced neuropathic pain in experimental animalsChaitali DiwaneRupali PatilPrashant VyavahareRajendra BhambarBackground: Neuropathic pain is a pain initiated or caused by a primary lesion or dysfunction of the nervous system. Material and Methods: In this study, we evaluated the effect of alcoholic extract of roots and rhizomes of Rubia cordifolia on the development and expression of neuropathic pain induced by paclitaxel in sciatic nerve ligated rats. A peripheral mononeuropathy was produced in adult Wistar rats by placing loosely constrictive ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated that hyperalgesia, allodynia, and spontaneous pain were produced. Treatment with paclitaxel (2 mg/kg i.p. on 7 th , 10 th , and 21 st day) produced long-lasting (2-3 weeks) heat hyperalgesia and cold allodynia in rats. Conclusion: Co-administration of R. cordifolia extract for 21 days significantly decreased pain indicating its usefulness in neuropathic pain.http://www.indianjpain.org/article.asp?issn=0970-5333;year=2015;volume=29;issue=3;spage=150;epage=154;aulast=DiwaneCold allodyniahyperalgesianeuropathic painpaclitaxelsciatic nerve ligation |
| spellingShingle | Chaitali Diwane Rupali Patil Prashant Vyavahare Rajendra Bhambar Protective effect of Rubia cordifolia in paclitaxel-induced neuropathic pain in experimental animals Indian Journal of Pain Cold allodynia hyperalgesia neuropathic pain paclitaxel sciatic nerve ligation |
| title | Protective effect of Rubia cordifolia in paclitaxel-induced neuropathic pain in experimental animals |
| title_full | Protective effect of Rubia cordifolia in paclitaxel-induced neuropathic pain in experimental animals |
| title_fullStr | Protective effect of Rubia cordifolia in paclitaxel-induced neuropathic pain in experimental animals |
| title_full_unstemmed | Protective effect of Rubia cordifolia in paclitaxel-induced neuropathic pain in experimental animals |
| title_short | Protective effect of Rubia cordifolia in paclitaxel-induced neuropathic pain in experimental animals |
| title_sort | protective effect of rubia cordifolia in paclitaxel induced neuropathic pain in experimental animals |
| topic | Cold allodynia hyperalgesia neuropathic pain paclitaxel sciatic nerve ligation |
| url | http://www.indianjpain.org/article.asp?issn=0970-5333;year=2015;volume=29;issue=3;spage=150;epage=154;aulast=Diwane |
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