Effects of longitudinal asymmetric distribution of a lipid core on plaque wall stress
The rupture of the atherosclerotic plaque is related to the mechanical stress and structural integrity of plaque wall tissues. In order to investigate the longitudinal asymmetry across the stenosis of the arterial plaque wall, asymmetric plaque wall models were constructed by skewing the lipid core...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Japan Society of Mechanical Engineers
2017-02-01
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| Series: | Journal of Biomechanical Science and Engineering |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jbse/12/1/12_16-00588/_pdf/-char/en |
| _version_ | 1811225749803237376 |
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| author | Pengsrorn CHHAI Jin Hyun LEE Kyehan RHEE |
| author_facet | Pengsrorn CHHAI Jin Hyun LEE Kyehan RHEE |
| author_sort | Pengsrorn CHHAI |
| collection | DOAJ |
| description | The rupture of the atherosclerotic plaque is related to the mechanical stress and structural integrity of plaque wall tissues. In order to investigate the longitudinal asymmetry across the stenosis of the arterial plaque wall, asymmetric plaque wall models were constructed by skewing the lipid core distribution in the upstream direction. Wall stress and blood flow in the coronary artery models were computationally analyzed considering fluid and structure interaction. The values of maximum cap stress increased, and its location moved toward the proximal cap as asymmetry increased. Hemodynamic wall shear stress (WSS) did not change much owing to negligible changes in luminal geometry, but the maximum WSS and the spatial gradient of WSS were higher in the asymmetry models than in the symmetry model. The pressure drop and pressure gradient across the stenosis were also higher in the asymmetry models. Because higher peak wall stress, wall strain, increased WSS, WSS gradient, pressure drop, and pressure gradient are correlated with weakening and rupture of the plaque wall, we suspect that longitudinal asymmetric distribution of the lipid core in the plaque could affect plaque wall stability and vulnerability. |
| first_indexed | 2024-04-12T09:12:40Z |
| format | Article |
| id | doaj.art-74baaf444cc24f66a66d0c12710f322f |
| institution | Directory Open Access Journal |
| issn | 1880-9863 |
| language | English |
| last_indexed | 2024-04-12T09:12:40Z |
| publishDate | 2017-02-01 |
| publisher | The Japan Society of Mechanical Engineers |
| record_format | Article |
| series | Journal of Biomechanical Science and Engineering |
| spelling | doaj.art-74baaf444cc24f66a66d0c12710f322f2022-12-22T03:38:55ZengThe Japan Society of Mechanical EngineersJournal of Biomechanical Science and Engineering1880-98632017-02-0112116-0058816-0058810.1299/jbse.16-00588jbseEffects of longitudinal asymmetric distribution of a lipid core on plaque wall stressPengsrorn CHHAI0Jin Hyun LEE1Kyehan RHEE2Department of Mechanical Engineering, Myongji UniversityDepartment of Mechanical Engineering, Myongji UniversityDepartment of Mechanical Engineering, Myongji UniversityThe rupture of the atherosclerotic plaque is related to the mechanical stress and structural integrity of plaque wall tissues. In order to investigate the longitudinal asymmetry across the stenosis of the arterial plaque wall, asymmetric plaque wall models were constructed by skewing the lipid core distribution in the upstream direction. Wall stress and blood flow in the coronary artery models were computationally analyzed considering fluid and structure interaction. The values of maximum cap stress increased, and its location moved toward the proximal cap as asymmetry increased. Hemodynamic wall shear stress (WSS) did not change much owing to negligible changes in luminal geometry, but the maximum WSS and the spatial gradient of WSS were higher in the asymmetry models than in the symmetry model. The pressure drop and pressure gradient across the stenosis were also higher in the asymmetry models. Because higher peak wall stress, wall strain, increased WSS, WSS gradient, pressure drop, and pressure gradient are correlated with weakening and rupture of the plaque wall, we suspect that longitudinal asymmetric distribution of the lipid core in the plaque could affect plaque wall stability and vulnerability.https://www.jstage.jst.go.jp/article/jbse/12/1/12_16-00588/_pdf/-char/enplaque rupturemechanical stressfluid structure interactioncomputational analysisplaque wall composition |
| spellingShingle | Pengsrorn CHHAI Jin Hyun LEE Kyehan RHEE Effects of longitudinal asymmetric distribution of a lipid core on plaque wall stress Journal of Biomechanical Science and Engineering plaque rupture mechanical stress fluid structure interaction computational analysis plaque wall composition |
| title | Effects of longitudinal asymmetric distribution of a lipid core on plaque wall stress |
| title_full | Effects of longitudinal asymmetric distribution of a lipid core on plaque wall stress |
| title_fullStr | Effects of longitudinal asymmetric distribution of a lipid core on plaque wall stress |
| title_full_unstemmed | Effects of longitudinal asymmetric distribution of a lipid core on plaque wall stress |
| title_short | Effects of longitudinal asymmetric distribution of a lipid core on plaque wall stress |
| title_sort | effects of longitudinal asymmetric distribution of a lipid core on plaque wall stress |
| topic | plaque rupture mechanical stress fluid structure interaction computational analysis plaque wall composition |
| url | https://www.jstage.jst.go.jp/article/jbse/12/1/12_16-00588/_pdf/-char/en |
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