Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease
Alzheimer’s disease (AD) is a degenerative disease of the central nervous system, the most common type of dementia in old age, which causes progressive loss of cognitive functions such as thoughts, memory, reasoning, behavioral abilities and social skills, affecting the daily life of patients. The d...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1125376/full |
| _version_ | 1797924571449393152 |
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| author | Yujuan Zhou Xu Wang Yingying Liu Yulu Gu Renjun Gu Geng Zhang Geng Zhang Qing Lin Qing Lin |
| author_facet | Yujuan Zhou Xu Wang Yingying Liu Yulu Gu Renjun Gu Geng Zhang Geng Zhang Qing Lin Qing Lin |
| author_sort | Yujuan Zhou |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a degenerative disease of the central nervous system, the most common type of dementia in old age, which causes progressive loss of cognitive functions such as thoughts, memory, reasoning, behavioral abilities and social skills, affecting the daily life of patients. The dentate gyrus of the hippocampus is a key area for learning and memory functions, and an important site of adult hippocampal neurogenesis (AHN) in normal mammals. AHN mainly consists of the proliferation, differentiation, survival and maturation of newborn neurons and occurs throughout adulthood, but the level of AHN decreases with age. In AD, the AHN will be affected to different degrees at different times, and its exact molecular mechanisms are increasingly elucidated. In this review, we summarize the changes of AHN in AD and its alteration mechanism, which will help lay the foundation for further research on the pathogenesis and diagnostic and therapeutic approaches of AD. |
| first_indexed | 2024-04-10T15:04:12Z |
| format | Article |
| id | doaj.art-74bd9a1bcb134a38a8b20adbf1587151 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-10T15:04:12Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-74bd9a1bcb134a38a8b20adbf15871512023-02-15T08:09:50ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-02-011710.3389/fnins.2023.11253761125376Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s diseaseYujuan Zhou0Xu Wang1Yingying Liu2Yulu Gu3Renjun Gu4Geng Zhang5Geng Zhang6Qing Lin7Qing Lin8Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou, ChinaKey Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou, ChinaDepartment of Physiology and Pathophysiology, Health Science Center, Peking University, Beijing, ChinaKey Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou, ChinaSchool of Chinese Medicine and School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaKey Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou, ChinaLaboratory of Clinical Applied Anatomy, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaKey Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou, ChinaLaboratory of Clinical Applied Anatomy, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, ChinaAlzheimer’s disease (AD) is a degenerative disease of the central nervous system, the most common type of dementia in old age, which causes progressive loss of cognitive functions such as thoughts, memory, reasoning, behavioral abilities and social skills, affecting the daily life of patients. The dentate gyrus of the hippocampus is a key area for learning and memory functions, and an important site of adult hippocampal neurogenesis (AHN) in normal mammals. AHN mainly consists of the proliferation, differentiation, survival and maturation of newborn neurons and occurs throughout adulthood, but the level of AHN decreases with age. In AD, the AHN will be affected to different degrees at different times, and its exact molecular mechanisms are increasingly elucidated. In this review, we summarize the changes of AHN in AD and its alteration mechanism, which will help lay the foundation for further research on the pathogenesis and diagnostic and therapeutic approaches of AD.https://www.frontiersin.org/articles/10.3389/fnins.2023.1125376/fulladult hippocampal neurogenesisAlzheimer’s diseaseenergy metabolismepigeneticsneuroinflammation |
| spellingShingle | Yujuan Zhou Xu Wang Yingying Liu Yulu Gu Renjun Gu Geng Zhang Geng Zhang Qing Lin Qing Lin Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease Frontiers in Neuroscience adult hippocampal neurogenesis Alzheimer’s disease energy metabolism epigenetics neuroinflammation |
| title | Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease |
| title_full | Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease |
| title_fullStr | Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease |
| title_full_unstemmed | Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease |
| title_short | Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer’s disease |
| title_sort | mechanisms of abnormal adult hippocampal neurogenesis in alzheimer s disease |
| topic | adult hippocampal neurogenesis Alzheimer’s disease energy metabolism epigenetics neuroinflammation |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1125376/full |
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